Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis. (Q48266897)

PubMed publication ID

17314303

10 February 2018

http://europepmc.org/abstract/MED/17314303

title

Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis (English)

1 reference

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11 May 2020

1 reference

John J Shacka

1

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11 May 2020

Barbara J Klocke

2

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11 May 2020

Chainllie Young

3

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11 May 2020

Masahiro Shibata

4

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11 May 2020

Yasuo Uchiyama

6

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11 May 2020

Paul Saftig

7

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11 May 2020

language of work or name

English

0 references

publication date

1 February 2007

1 reference

PubMed publication ID

17314303

10 February 2018

http://europepmc.org/abstract/MED/17314303

published in

Journal of Neuroscience

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11 May 2020

volume

27

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673541&resulttype=core&format=json

11 May 2020

issue

8

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11 May 2020

page(s)

2081-2090

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Trophic support promotes survival of bcl-x-deficient telencephalic cells in vitro

11 May 2020

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Growth factors prevent changes in Bcl-2 and Bax expression and neuronal apoptosis induced by nitric oxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

p38 MAP kinase mediates bax translocation in nitric oxide-induced apoptosis in neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/17314303

1 reference

12 December 2020

Caspases, apoptosis, and Alzheimer disease: causation, correlation, and confusion

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Chloroquine-induced neuronal cell death is p53 and Bcl-2 family-dependent but caspase-independent

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

The neuropathogenic contributions of lysosomal dysfunction

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

The neuronal ceroid-lipofuscinoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Oxidative stress and nitration in neurodegeneration: cause, effect, or association?

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Nitric-oxide-induced Bax integration into the mitochondrial membrane commits MDA-MB-468 cells to apoptosis: essential role of Akt

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Current state of clinical and morphological features in human NCL.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Role of Bcl-2 family proteins in a non-apoptotic programmed cell death dependent on autophagy genes

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Inhibition of macroautophagy triggers apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Extensive involvement of autophagy in Alzheimer disease: an immuno-electron microscopy study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Participation of autophagy in the degeneration process of rat hepatocytes after transplantation following prolonged cold preservation

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Cathepsin deficiency as a model for neuronal ceroid lipofuscinoses

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease).

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Bafilomycin A1 inhibits chloroquine-induced death of cerebellar granule neurons

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Two distinct signaling pathways regulate peroxynitrite-induced apoptosis in PC12 cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Cathepsin D deficiency is associated with a human neurodegenerative disorder

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Bcl-2 family and the central nervous system: from rheostat to real complex.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Autophagic stress in neuronal injury and disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Immunolocalization of cathepsin D in normal and neoplastic human tissues

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

An improved cupric-silver method for impregnation of axonal and terminal degeneration

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

The distribution of cathepsin D in rat tissues determined by immunocytochemistry

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

NMDA and kainate induce internucleosomal DNA cleavage associated with both apoptotic and necrotic cell death in the neonatal rat brain

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Bax-deficient mice with lymphoid hyperplasia and male germ cell death

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Simultaneous detection of TDT-mediated dUTP-biotin nick end-labeling (TUNEL)-positive cells and multiple immunohistochemical markers in single tissue sections

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

The endosomal-lysosomal system of neurons: new roles

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

BAX is required for neuronal death after trophic factor deprivation and during development

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Apoptosis and autophagy in nigral neurons of patients with Parkinson's disease.

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Bax deficiency prevents the increased cell death of immature neurons in bcl-x-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Widespread elimination of naturally occurring neuronal death in Bax-deficient mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

Bax directly induces release of cytochrome c from isolated mitochondria

1 reference

https://pubmed.ncbi.nlm.nih.gov/17314303

12 December 2020

10.1523/JNEUROSCI.5577-06.2007

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673541&resulttype=core&format=json

release_vjcj4umkhnbrfmrg6r4oxw6nom

11 May 2020

Fatcat ID

0 references

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6673541&resulttype=core&format=json

11 May 2020

PubMed publication ID

17314303

1 reference