Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease. (Q48095855)

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2 January 2020

title

Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease (English)

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2 January 2020

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1

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2 January 2020

Anders Björklund

4

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2 January 2020

Manolo Carta

2

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2 January 2020

author name string

Christian Winkler

3

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2 January 2020

Deniz Kirik

5

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language of work or name

English

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publication date

1 July 2007

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2 January 2020

published in

Journal of Neuroscience

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2 January 2020

volume

27

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issue

30

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2 January 2020

page(s)

8011-8022

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describes a project that uses

2 January 2020

ImageJ

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11 June 2022

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inferred from PubMed Central ID database lookup

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Intranigral transplants of GABA-rich striatal tissue induce behavioral recovery in the rat Parkinson model and promote the effects obtained by intrastriatal dopaminergic transplants

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Stereological methods for estimating the total number of neurons and synapses: issues of precision and bias

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Sequential bilateral transplantation in Parkinson's disease: effects of the second graft

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Embryonic ventral mesencephalic grafts improve levodopa-induced dyskinesia in a rat model of Parkinson's disease

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Bilateral caudate and putamen grafts of embryonic mesencephalic tissue treated with lazaroids in Parkinson's disease

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The Importance of Graft Placement and Task Complexity for Transplant-Induced Recovery of Simple and Complex Sensorimotor Deficits in Dopamine Denervated Rats

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L-DOPA-induced dyskinesia in the intrastriatal 6-hydroxydopamine model of parkinson's disease: relation to motor and cellular parameters of nigrostriatal function

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Dopaminergic transplants in experimental parkinsonism: cellular mechanisms of graft-induced functional recovery

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Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)

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Elimination of serotonergic cells induces a marked increase in generation of dopaminergic neurons from mesencephalic precursors

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Constitutive activity of the serotonin2C receptor inhibits in vivo dopamine release in the rat striatum and nucleus accumbens.

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The 5-HT1A receptor and behavioral stimulation in the rat: effects of 8-OHDPAT on spontaneous and cocaine-induced behavior

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12 December 2020

Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor.

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Cell transplantation in Parkinson's disease: how can we make it work?

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Serotonergic hyperinnervation into the dopaminergic denervated striatum compensates for dopamine conversion from exogenously administered l-DOPA.

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Mice over-expressing the 5-HT(1A) receptor in cortex and dentate gyrus display exaggerated locomotor and hypothermic response to 8-OH-DPAT.

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12 December 2020

Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia

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12 December 2020

The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat.

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12 December 2020

An investigation of the problem of two-layered immunohistochemical staining in paraformaldehyde fixed sections

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12 December 2020

The "motor complication syndrome" in rats with 6-OHDA lesions treated chronically with L-DOPA: relation to dose and route of administration

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12 December 2020

Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats

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12 December 2020

Time-course of recovery of dopamine neuron activity during reinnervation of the denervated striatum by fetal mesencephalic grafts as assessed by in vivo voltammetry

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Grafts of embryonic substantia nigra reinnervating the ventrolateral striatum ameliorate sensorimotor impairments and akinesia in rats with 6-OHDA lesions of the nigrostriatal pathway

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10.1523/JNEUROSCI.2079-07.2007

Identifiers

DOI

1 reference

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2 January 2020

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2 January 2020

PubMed publication ID

17652591

1 reference