Negative regulation of T cell activation (Q47933721)

6 February 2018

http://europepmc.org/abstract/MED/9638368

review article

1 reference

title

Negative regulation of T cell activation (English)

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6 February 2018

http://europepmc.org/abstract/MED/9638368

1 reference

T Saito

1

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6 February 2018

http://europepmc.org/abstract/MED/9638368

publication date

1 June 1998

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6 February 2018

http://europepmc.org/abstract/MED/9638368

published in

Current Opinion in Immunology

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6 February 2018

http://europepmc.org/abstract/MED/9638368

volume

10

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6 February 2018

http://europepmc.org/abstract/MED/9638368

issue

3

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6 February 2018

http://europepmc.org/abstract/MED/9638368

page(s)

313-321

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6 February 2018

http://europepmc.org/abstract/MED/9638368

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CD80 (B7-1) binds both CD28 and CTLA-4 with a low affinity and very fast kinetics

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Covalent dimerization of CD28/CTLA-4 and oligomerization of CD80/CD86 regulate T cell costimulatory interactions

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CTLA-4 can function as a negative regulator of T cell activation

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Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4

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Normal thymic selection, normal viability and decreased lymphoproliferation in T cell receptor-transgenic CTLA-4-deficient mice

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Cytotoxic T lymphocyte-associated molecule-4, a high-avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail

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Tyrosine phosphorylation controls internalization of CTLA-4 by regulating its interaction with clathrin-associated adaptor complex AP-2

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Cytotoxic T lymphocyte antigen 4 (CTLA-4) interferes with extracellular signal-regulated kinase (ERK) and Jun NH2-terminal kinase (JNK) activation, but does not affect phosphorylation of T cell receptor zeta and ZAP70.

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Immunoreceptor DAP12 bearing a tyrosine-based activation motif is involved in activating NK cells

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Activation of the Lck tyrosine kinase targets cell surface T cell antigen receptors for lysosomal degradation

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T cells from late tumor-bearing mice express normal levels of p56lck, p59fyn, ZAP-70, and CD3 zeta despite suppressed cytolytic activity

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HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression

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Dimerization-induced inhibition of receptor protein tyrosine phosphatase function through an inhibitory wedge

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7 January 2021

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Identifiers

DOI

1 reference

6 February 2018

http://europepmc.org/abstract/MED/9638368

1 reference

6 February 2018