The RanGTP gradient - a GPS for the mitotic spindle (Q46603162)

23 December 2017

http://europepmc.org/abstract/MED/18469014

title

The RanGTP gradient - a GPS for the mitotic spindle (English)

1 reference

23 December 2017

http://europepmc.org/abstract/MED/18469014

author

Rebecca Heald

series ordinal

2

1 reference

23 December 2017

http://europepmc.org/abstract/MED/18469014

author name string

Petr Kalab

series ordinal

1

1 reference

23 December 2017

http://europepmc.org/abstract/MED/18469014

language of work or name

English

0 references

publication date

1 May 2008

1 reference

23 December 2017

http://europepmc.org/abstract/MED/18469014

published in

Journal of Cell Science

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23 December 2017

http://europepmc.org/abstract/MED/18469014

volume

121

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23 December 2017

http://europepmc.org/abstract/MED/18469014

issue

Pt 10

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23 December 2017

http://europepmc.org/abstract/MED/18469014

page(s)

1577-1586

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23 December 2017

http://europepmc.org/abstract/MED/18469014

cites work

NuSAP, a mitotic RanGTP target that stabilizes and cross-links microtubules

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Ran is required before metaphase for spindle assembly and chromosome alignment and after metaphase for chromosome segregation and spindle midbody organization

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

HURP Is a Ran-Importin β-Regulated Protein that Stabilizes Kinetochore Microtubules in the Vicinity of Chromosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Alp7/TACC is a crucial target in Ran-GTPase-dependent spindle formation in fission yeast.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Aurora-A kinase regulates breast cancer associated gene 1 inhibition of centrosome-dependent microtubule nucleation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Gradients in the self-organization of the mitotic spindle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The human Nup107-160 nuclear pore subcomplex contributes to proper kinetochore functions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Regulating access to the genome: nucleocytoplasmic transport throughout the cell cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The BRCA1/BARD1 heterodimer modulates ran-dependent mitotic spindle assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Aurora B phosphorylates multiple sites on mitotic centromere-associated kinesin to spatially and temporally regulate its function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The bicoid protein determines position in the Drosophila embryo in a concentration-dependent manner

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Chromatin docking and exchange activity enhancement of RCC1 by histones H2A and H2B

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Self-organization of MTOCs replaces centrosome function during acentrosomal spindle assembly in live mouse oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/18469014

1 reference

12 December 2020

RCC1 isoforms differ in their affinity for chromatin, molecular interactions and regulation by phosphorylation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

In vivo analysis of importin alpha proteins reveals cellular proliferation inhibition and substrate specificity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Function and regulation of Maskin, a TACC family protein, in microtubule growth during mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The Xenopus TACC homologue, maskin, functions in mitotic spindle assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The Survivin-Crm1 interaction is essential for chromosomal passenger complex localization and function

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Characterization of Ran-driven cargo transport and the RanGTPase system by kinetic measurements and computer simulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Triggering neural differentiation of ES cells by subtype switching of importin-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Aurora A phosphorylation of TACC3/maskin is required for centrosome-dependent microtubule assembly in mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Ran-GTP regulates kinetochore attachment in somatic cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

A mitotic lamin B matrix induced by RanGTP required for spindle assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Regulated Ran-binding protein 1 activity is required for organization and function of the mitotic spindle in mammalian cells in vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Mechanisms of Receptor-Mediated Nuclear Import and Nuclear Export

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Ran modulates spindle assembly by regulating a subset of TPX2 and Kid activities including Aurora A activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Karyopherin flexibility in nucleocytoplasmic transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Spatial and temporal control of nuclear envelope assembly by Ran GTPase.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

A Rae1-containing ribonucleoprotein complex is required for mitotic spindle assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

A centriole- and RanGTP-independent spindle assembly pathway in meiosis I of vertebrate oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

N-terminal alpha-methylation of RCC1 is necessary for stable chromatin association and normal mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Return of the matrix.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Xnf7 contributes to spindle integrity through its microtubule-bundling activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Visualization of a Ran-GTP gradient in interphase and mitotic Xenopus egg extracts

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Chromosomal passengers: conducting cell division

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Importin beta is transported to spindle poles during mitosis and regulates Ran-dependent spindle assembly factors in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Structure of importin-beta bound to the IBB domain of importin-alpha

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Analysis of a RanGTP-regulated gradient in mitotic somatic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/18469014

1 reference

12 December 2020

Rescue of bicoid mutant Drosophila embryos by Bicoid fusion proteins containing heterologous activating sequences

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Probing the limits to positional information

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Systems analysis of Ran transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Tumor cell dependence on Ran-GTP-directed mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

RANBP1 localizes a subset of mitotic regulatory factors on spindle microtubules and regulates chromosome segregation in human cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Phosphorylation of RCC1 in mitosis is essential for producing a high RanGTP concentration on chromosomes and for spindle assembly in mammalian cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Identification of genes periodically expressed in the human cell cycle and their expression in tumors

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The Kinetic Mechanism of Ran-Nucleotide Exchange Catalyzed by RCC1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

A role for NuSAP in linking microtubules to mitotic chromosomes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Running on Ran: nuclear transport and the mitotic spindle.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Phosphorylation of maskin by Aurora-A is regulated by RanGTP and importin beta

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The production and localization of GTP-bound ran in mitotic mammalian tissue culture cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Structural basis for the nuclear protein import cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Aurora-A: the maker and breaker of spindle poles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Nuclear export of RNA.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Ran binds to chromatin by two distinct mechanisms.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

HURP is part of a Ran-dependent complex involved in spindle formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Molecular profiling of laser-microdissected matched tumor and normal breast tissue identifies karyopherin alpha2 as a potential novel prognostic marker in breast cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Identification of Ras-related nuclear protein, targeting protein for xenopus kinesin-like protein 2, and stearoyl-CoA desaturase 1 as promising cancer targets from an RNAi-based screen.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Crm1 is a mitotic effector of Ran-GTP in somatic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Stathmin-tubulin interaction gradients in motile and mitotic cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Ran localizes around the microtubule spindle in vivo during mitosis in Drosophila embryos

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Spatial coordination of spindle assembly by chromosome-mediated signaling gradients

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Centrosomes and cancer: lessons from a TACC.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Cell-surface and mitotic-spindle RHAMM: moonlighting or dual oncogenic functions?

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Part of Ran is associated with AKAP450 at the centrosome: involvement in microtubule-organizing activity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

HURP controls spindle dynamics to promote proper interkinetochore tension and efficient kinetochore capture.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Nucleocytoplasmic transport: taking an inventory

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Overexpression of Eg5 causes genomic instability and tumor formation in mice

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Crossing the nuclear envelope: hierarchical regulation of nucleocytoplasmic transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Aurora A kinase-coated beads function as microtubule-organizing centers and enhance RanGTP-induced spindle assembly.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Aurora A regulates the activity of HURP by controlling the accessibility of its microtubule-binding domain

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Rae1 interaction with NuMA is required for bipolar spindle formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The case for survivin as a regulator of microtubule dynamics and cell-death decisions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Nuclear export is essential for the tumor-promoting activity of survivin.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The Ran GTPase as a marker of chromosome position in spindle formation and nuclear envelope assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Stochastic gene expression: from single molecules to the proteome

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Importin beta is a mitotic target of the small GTPase Ran in spindle assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Importin alpha/beta and Ran-GTP regulate XCTK2 microtubule binding through a bipartite nuclear localization signal

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Chromosomal association of Ran during meiotic and mitotic divisions

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Stability and nuclear dynamics of the bicoid morphogen gradient

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Role of importin-beta in coupling Ran to downstream targets in microtubule assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Nup358 integrates nuclear envelope breakdown with kinetochore assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Drosophila melanogaster importin alpha1 and alpha3 can replace importin alpha2 during spermatogenesis but not oogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Loading and unloading: orchestrating centrosome duplication and spindle assembly by Ran/Crm1

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

SUMO-1 targets RanGAP1 to kinetochores and mitotic spindles

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Molecular mechanism of the nuclear protein import cycle

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Importin-beta and the small guanosine triphosphatase Ran mediate chromosome loading of the human chromokinesin Kid.

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

The Ran GTPase mediates chromatin signaling to control cortical polarity during polar body extrusion in mouse oocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Phosphorylation regulates the dynamic interaction of RCC1 with chromosomes during mitosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

XRHAMM functions in ran-dependent microtubule nucleation and pole formation during anastral spindle assembly

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Mitotic spindle morphogenesis: Ran on the microtubule cytoskeleton and beyond

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Morpheus unbound: reimagining the morphogen gradient

1 reference

https://pubmed.ncbi.nlm.nih.gov/18469014

12 December 2020

Identifiers

DOI

10.1242/JCS.005959

1 reference

23 December 2017

http://europepmc.org/abstract/MED/18469014

PMC publication ID

7185306

0 references

1 reference

23 December 2017