p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment (Q44859686)

6 December 2017

title

p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment (English)

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6 December 2017

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Yi Pan

1

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6 December 2017

Patricia R Oprysko

2

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6 December 2017

Andrew M Asham

3

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6 December 2017

Cameron J Koch

4

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6 December 2017

Marie Celeste Simon

5

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6 December 2017

language of work or name

English

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publication date

1 June 2004

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6 December 2017

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6 December 2017

volume

23

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6 December 2017

issue

29

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6 December 2017

page(s)

4975-4983

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p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia

6 December 2017

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Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus

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Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes

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PUMA mediates the apoptotic response to p53 in colorectal cancer cells

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p38 Mitogen-activated protein kinase mediates hypoxic regulation of Mdm2 and p53 in neurons

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Hypoxia attenuates the p53 response to cellular damage

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7 January 2021

Stabilization of wild-type p53 by hypoxia-inducible factor 1alpha

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7 January 2021

Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia

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7 January 2021

A conserved family of prolyl-4-hydroxylases that modify HIF

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7 January 2021

Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis

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7 January 2021

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7 January 2021

C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation

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7 January 2021

Nuclear export is required for degradation of endogenous p53 by MDM2 and human papillomavirus E6

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7 January 2021

Hypoxia inhibits G1/S transition through regulation of p27 expression

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7 January 2021

The complexity of p53 modulation: emerging patterns from divergent signals

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7 January 2021

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia

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7 January 2021

Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours

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7 January 2021

Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status.

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7 January 2021

Hypoxia links ATR and p53 through replication arrest

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7 January 2021

Mdm2 promotes the rapid degradation of p53

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7 January 2021

Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL

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7 January 2021

Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation.

1 reference

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7 January 2021

Regulation of p53 stability by Mdm2

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7 January 2021

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

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7 January 2021

Unmasking of phosphorylation-sensitive epitopes on p53 and Mdm2 by a simple Western-phosphatase procedure

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7 January 2021

Genotoxic and non-genotoxic pathways of p53 induction

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7 January 2021

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7 January 2021

Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein.

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7 January 2021

Regulation of proliferation-survival decisions during tumor cell hypoxia

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7 January 2021

Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells.

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7 January 2021

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

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7 January 2021

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

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7 January 2021

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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7 January 2021

p53: good cop/bad cop.

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7 January 2021

The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development

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7 January 2021

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

1 reference

7 January 2021

The p53-mdm-2 autoregulatory feedback loop

1 reference

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7 January 2021

A functional p53-responsive intronic promoter is contained within the humanmdm2gene

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207657

7 January 2021

Identifiers

DOI

10.1038/SJ.ONC.1207657

1 reference

6 December 2017

1 reference