Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine (Q44168441)

http://europepmc.org/abstract/PMC/5791571

19 February 2018

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3 October 2022

Characterization of T-cell immune responses in clinical trials of the candidate RTS,S malaria vaccine (English)

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http://europepmc.org/abstract/PMC/5791571

19 February 2018

main subject

malaria

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Plasmodium falciparum malaria

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hemic and immune systems

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Plasmodium falciparum

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18 July 2021

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Philippe Moris

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http://europepmc.org/abstract/PMC/5791571

19 February 2018

Erik Jongert

series ordinal

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http://europepmc.org/abstract/PMC/5791571

19 February 2018

Robbert G van der Most

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19 February 2018

language of work or name

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21 September 2017

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http://europepmc.org/abstract/PMC/5791571

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Human Vaccines & Immunotherapeutics

inferred from page(s)

published in

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http://europepmc.org/abstract/PMC/5791571

19 February 2018

23 March 2019

20 June 2019

30 June 2019

12 October 2019

18 October 2019

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28 May 2020

18 July 2021

3 October 2022

14

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http://europepmc.org/abstract/PMC/5791571

19 February 2018

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19 February 2018

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19 February 2018

copyright license

Creative Commons Attribution 4.0 International

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3 October 2022

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Reversible Conformational Change in the Plasmodium falciparum Circumsporozoite Protein Masks Its Adhesion Domains

25 May 2018

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Ad35.CS.01-RTS,S/AS01 Heterologous Prime Boost Vaccine Efficacy against Sporozoite Challenge in Healthy Malaria-Naïve Adults

25 May 2018

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Proteolytic Cleavage of the Plasmodium falciparum Circumsporozoite Protein Is a Target of Protective Antibodies

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Malaria and the liver: immunological hide-and-seek or subversion of immunity from within?

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Antigen-driven focal inflammatory death of malaria liver stages

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APC licensing and CD4+T cell help in liver-stage malaria

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Evaluation of the immune response to RTS,S/AS01 and RTS,S/AS02 adjuvanted vaccines: randomized, double-blind study in malaria-naïve adults

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The Split Virus Influenza Vaccine rapidly activates immune cells through Fcγ receptors

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Efficacy and safety of the RTS,S/AS01 malaria vaccine during 18 months after vaccination: a phase 3 randomized, controlled trial in children and young infants at 11 African sites

25 May 2018

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The relationship between RTS,S vaccine-induced antibodies, CD4⁺ T cell responses and protection against Plasmodium falciparum infection

25 May 2018

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A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E

25 May 2018

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A spatially-organized multicellular innate immune response in lymph nodes limits systemic pathogen spread

25 May 2018

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Strategy of lipid recognition by invariant natural killer T cells: 'one for all and all for one'.

25 May 2018

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Antigen-specific IL-2 secretion correlates with NK cell responses after immunization of Tanzanian children with the RTS,S/AS01 malaria vaccine

25 May 2018

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25 May 2018

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Cytometry by time-of-flight shows combinatorial cytokine expression and virus-specific cell niches within a continuum of CD8+ T cell phenotypes

25 May 2018

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Chronicle of a death foretold: Plasmodium liver stage parasites decide on the fate of the host cell

25 May 2018

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Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria

25 May 2018

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Induction of strong HIV-1-specific CD4+ T-cell responses using an HIV-1 gp120/NefTat vaccine adjuvanted with AS02A in antiretroviral-treated HIV-1-infected individuals.

25 May 2018

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Safety and efficacy of the RTS, S/AS01 E candidate malaria vaccine given with expanded-programme-on-immunisation vaccines: 19 month follow-up of a randomised, open-label, phase 2 trial

25 May 2018

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Protective immunity induced with the RTS,S/AS vaccine is associated with IL-2 and TNF-α producing effector and central memory CD4 T cells

25 May 2018

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Targeting the diverse immunological functions expressed by hepatic NKT cells

25 May 2018

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T cell responses to the RTS,S/AS01e and RTS,S/AS02D malaria candidate vaccines administered according to different schedules to Ghanaian children

25 May 2018

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25 May 2018

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Recent clinical experience with vaccines using MPL- and QS-21-containing adjuvant systems

25 May 2018

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Induction of Plasmodium falciparum-specific CD4+ T cells and memory B cells in Gabonese children vaccinated with RTS,S/AS01(E) and RTS,S/AS02(D)

25 May 2018

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Inhibitory effect of TNF-α on malaria pre-erythrocytic stage development: influence of host hepatocyte/parasite combinations

25 May 2018

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The malaria circumsporozoite protein has two functional domains, each with distinct roles as sporozoites journey from mosquito to mammalian host

25 May 2018

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25 May 2018

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25 May 2018

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Adenovirus particles that display the Plasmodium falciparum circumsporozoite protein NANP repeat induce sporozoite-neutralizing antibodies in mice

25 May 2018

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Evaluation of the safety and immunogenicity of two antigen concentrations of the Mtb72F/AS02(A) candidate tuberculosis vaccine in purified protein derivative-negative adults

25 May 2018

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NK cells as effectors of acquired immune responses: effector CD4+ T cell-dependent activation of NK cells following vaccination

25 May 2018

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Immunological mechanisms underlying protection mediated by RTS,S: a review of the available data

25 May 2018

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From the circumsporozoite protein to the RTS, S/AS candidate vaccine

25 May 2018

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How might infant and paediatric immune responses influence malaria vaccine efficacy?

25 May 2018

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The development of the RTS,S malaria vaccine candidate: challenges and lessons

25 May 2018

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The relationship between human effector and memory T cells measured by ex vivo and cultured ELISPOT following recent and distal priming

25 May 2018

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Plasmodium falciparum-specific cellular immune responses after immunization with the RTS,S/AS02D candidate malaria vaccine in infants living in an area of high endemicity in Mozambique

25 May 2018

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Evaluation of RTS,S/AS02A and RTS,S/AS01B in adults in a high malaria transmission area.

25 May 2018

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Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate

25 May 2018

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Randomized, double-blind, phase 2a trial of falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults: safety, efficacy, and immunologic associates of protection

25 May 2018

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Long-term safety and efficacy of the RTS,S/AS02A malaria vaccine in Mozambican children

25 May 2018

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Acquired immunity to malaria

25 May 2018

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Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age

25 May 2018

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T-cell quality in memory and protection: implications for vaccine design

25 May 2018

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Class II-restricted protective immunity induced by malaria sporozoites

25 May 2018

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Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite

25 May 2018

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Priming with an adenovirus 35-circumsporozoite protein (CS) vaccine followed by RTS,S/AS01B boosting significantly improves immunogenicity to Plasmodium falciparum CS compared to that with either malaria vaccine alone

25 May 2018

1 reference

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Plasmodium sporozoites trickle out of the injection site

25 May 2018

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Early gamma interferon and interleukin-2 responses to vaccination predict the late resting memory in malaria-naïve and malaria-exposed individuals

25 May 2018

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Interferon-gamma, the functional plasticity of the ubiquitin-proteasome system, and MHC class I antigen processing

25 May 2018

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Naturally acquired immunity to Plasmodium falciparum malaria in Africa

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Intravital observation of Plasmodium berghei sporozoite infection of the liver

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Plasmodium sporozoite molecular cell biology

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Sneaking in through the back entrance: the biology of malaria liver stages

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Unique T cell effector functions elicited by Plasmodium falciparum epitopes in malaria-exposed Africans tested by three T cell assays.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Efficacy of recombinant circumsporozoite protein vaccine regimens against experimental Plasmodium falciparum malaria

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Migration of Plasmodium sporozoites through cells before infection.

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Long-term efficacy and immune responses following immunization with the RTS,S malaria vaccine

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Mouse CD1-specific NK1 T cells: development, specificity, and function

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

T cell responses to pre-erythrocytic stages of malaria: role in protection and vaccine development against pre-erythrocytic stages

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Safety, immunogenicity, and efficacy of a recombinantly produced Plasmodium falciparum circumsporozoite protein-hepatitis B surface antigen subunit vaccine

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Specificity of protection of man immunized against sporozoite-induced falciparum malaria

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Efficacy of murine malaria sporozoite vaccines: implications for human vaccine development

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Gamma interferon, CD8+ T cells and antibodies required for immunity to malaria sporozoites

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Immunogenicity of synthetic peptides from circumsporozoite protein of Plasmodium falciparum

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Dual action of anti-sporozoite antibodies in vitro

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Rationale for the development of an engineered sporozoite malaria vaccine

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Cellular and molecular synergy in AS01-adjuvanted vaccines results in an early IFNγ response promoting vaccine immunogenicity

25 May 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Interferon-mediated innate immune responses against malaria parasite liver stages

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

A phase 1/2 clinical trial evaluating safety and immunogenicity of a varicella zoster glycoprotein e subunit vaccine candidate in young and older adults

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Immunization with the RTS,S/AS malaria vaccine induces IFN-γ(+)CD4 T cells that recognize only discrete regions of the circumsporozoite protein and these specificities are maintained following booster immunizations and challenge

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Further analysis of correlates of protection from a phase 2a trial of the falciparum malaria vaccines RTS,S/AS01B and RTS,S/AS02A in malaria-naive adults

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Expression of genes associated with immunoproteasome processing of major histocompatibility complex peptides is indicative of protection with adjuvanted RTS,S malaria vaccine.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Recombinant Liver Stage Antigen-1 (LSA-1) formulated with AS01 or AS02 is safe, elicits high titer antibody and induces IFN-gamma/IL-2 CD4+ T cells but does not protect against experimental Plasmodium falciparum infection

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

IL-2 producing memory CD4+ T lymphocytes are closely associated with the generation of IgG-secreting plasma cells.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Phase 2a trial of 0, 1, and 3 month and 0, 7, and 28 day immunization schedules of malaria vaccine RTS,S/AS02 in malaria-naïve adults at the Walter Reed Army Institute of Research

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

The circumsporozoite protein is an immunodominant protective antigen in irradiated sporozoites

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Quantitative imaging of Plasmodium transmission from mosquito to mammal.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Direct access to CD4+ T cells specific for defined antigens according to CD154 expression.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Interferon-gamma is an autocrine mediator for dendritic cell maturation

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

A CD4(+) T-cell immune response to a conserved epitope in the circumsporozoite protein correlates with protection from natural Plasmodium falciparum infection and disease

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Cellular immunity induced by the recombinant Plasmodium falciparum malaria vaccine, RTS,S/AS02, in semi-immune adults in The Gambia

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Protective immunity induced with malaria vaccine, RTS,S, is linked to Plasmodium falciparum circumsporozoite protein-specific CD4+ and CD8+ T cells producing IFN-gamma

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

NKT cells from normal and tumor-bearing human livers are phenotypically and functionally distinct from murine NKT cells

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Opsonization by antigen-specific antibodies as a mechanism of protective immunity induced by Plasmodium falciparum circumsporozoite protein-based vaccine

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Efficacy of RTS,S/AS02 malaria vaccine against Plasmodium falciparum infection in semi-immune adult men in The Gambia: a randomised trial

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Potent induction of focused Th1-type cellular and humoral immune responses by RTS,S/SBAS2, a recombinant Plasmodium falciparum malaria vaccine.

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

A preliminary evaluation of a recombinant circumsporozoite protein vaccine against Plasmodium falciparum malaria. RTS,S Malaria Vaccine Evaluation Group

15 August 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=5791571

Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-15

15 August 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F21645515.2017.1381809

Natural T cells in the human liver: cytotoxic lymphocytes with dual T cell and natural killer cell phenotype and function are phenotypically heterogenous and include Vα24-JαQ and γδ T cell receptor bearing cells

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F21645515.2017.1381809

Specificity of Protective Immunity produced by X-irradiated Plasmodium berghei Sporozoites

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1080%2F21645515.2017.1381809

Immune effector mechanisms in malaria

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/28934066

12 December 2020

A live-cell assay to detect antigen-specific CD4+ T cells with diverse cytokine profiles

1 reference

https://pubmed.ncbi.nlm.nih.gov/28934066

12 December 2020

Interleukin-2-activated rat natural killer cells express inducible nitric oxide synthase that contributes to cytotoxic function and interferon-gamma production

1 reference

https://pubmed.ncbi.nlm.nih.gov/28934066

12 December 2020

Primed antigen-specific CD4+ T cells are required for NK cell activation in vivo upon Leishmania major infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/28934066

12 December 2020

10.1080/21645515.2017.1381809

Identifiers

DOI

1 reference

http://europepmc.org/abstract/PMC/5791571

19 February 2018

PMC publication ID

5791571

1 reference

http://europepmc.org/abstract/PMC/5791571

19 February 2018

PubMed publication ID

28934066

1 reference