Thermodynamics of Nanobody Binding to Lactose Permease. (Q43802615)

PubMed publication ID

27686537

26 November 2017

title

Thermodynamics of Nanobody Binding to Lactose Permease (English)

1 reference

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14 May 2020

5

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14 May 2020

Els Pardon

4

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6

H Ronald Kaback

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14 May 2020

3

Xiaoxu Jiang

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14 May 2020

author name string

Parameswaran Hariharan

1

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14 May 2020

Magnus Andersson

2

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14 May 2020

Lan Guan

7

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14 May 2020

language of work or name

English

0 references

publication date

30 September 2016

1 reference

PubMed publication ID

26 November 2017

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6478161&resulttype=core&format=json

14 May 2020

volume

55

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14 May 2020

issue

42

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14 May 2020

page(s)

5917-5926

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The kamikaze approach to membrane transport

14 May 2020

cites work

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

The C-4 hydroxyl group of galactopyranosides is the major determinant for ligand recognition by the lactose permease of Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structure and mechanism of the lactose permease of Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Thermodynamic studies of the mechanism of metal binding to the Escherichia coli zinc transporter YiiP.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Extending the treatment of backbone energetics in protein force fields: limitations of gas-phase quantum mechanics in reproducing protein conformational distributions in molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Binding affinity of lactose permease is not altered by the H+ electrochemical gradient

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https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Scalable molecular dynamics with NAMD

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https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structural evidence for induced fit and a mechanism for sugar/H+ symport in LacY.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Lessons from lactose permease

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https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Energetics of ligand-induced conformational flexibility in the lactose permease of Escherichia coli

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Automated builder and database of protein/membrane complexes for molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structural determination of wild-type lactose permease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Opening and closing of the periplasmic gate in lactose permease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Protonation and sugar binding to LacY.

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https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Isothermal titration calorimetry reveals differential binding thermodynamics of variable region-identical antibodies differing in constant region for a univalent ligand

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

The Thermodynamics of Protein–Ligand Interaction and Solvation: Insights for Ligand Design

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Mechanism of melibiose/cation symport of the melibiose permease of Salmonella typhimurium

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

The alternating access transport mechanism in LacY.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Site-directed alkylation studies with LacY provide evidence for the alternating access model of transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Opening the periplasmic cavity in lactose permease is the limiting step for sugar binding

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Lactose permease and the alternating access mechanism

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

MATCH: an atom-typing toolset for molecular mechanics force fields.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Proton-coupled dynamics in lactose permease

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Crystal structure of a eukaryotic phosphate transporter

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structural basis for substrate transport in the GLUT-homology family of monosaccharide transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Trp replacements for tightly interacting Gly-Gly pairs in LacY stabilize an outward-facing conformation

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structure-based mechanism for Na+/melibiose symport by MelB

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structure of sugar-bound LacY

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Galactoside-binding site in LacY.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

A general protocol for the generation of Nanobodies for structural biology

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Crystal structure of the human glucose transporter GLUT1

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Insights into the inhibitory mechanisms of the regulatory protein IIA(Glc) on melibiose permease activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Outward-facing conformers of LacY stabilized by nanobodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

A chemiosmotic mechanism of symport

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Thermodynamic mechanism for inhibition of lactose permease by the phosphotransferase protein IIAGlc

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Isothermal titration calorimetry of ion-coupled membrane transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Anomalous behavior of water inside the SecY translocon

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structure and mechanism of the mammalian fructose transporter GLUT5

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Transient conformers of LacY are trapped by nanobodies

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Melibiose permease of Escherichia coli: large scale purification and evidence that H+, Na+, and Li+ sugar symport is catalyzed by a single polypeptide.

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Thermodynamics of ferredoxin binding to ferredoxin:NADP+ reductase and the role of water at the complex interface

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Comparative protein modelling by satisfaction of spatial restraints

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

VMD: visual molecular dynamics

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

Structural studies of the melibiose permease of Escherichia coli by fluorescence resonance energy transfer. I. Evidence for ion-induced conformational change

1 reference

https://pubmed.ncbi.nlm.nih.gov/27686537

12 December 2020

10.1021/ACS.BIOCHEM.6B00826

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=PMCID:PMC6478161&resulttype=core&format=json

14 May 2020

1 reference

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14 May 2020

PubMed publication ID

27686537

1 reference