Presenilin 1 (Q4377404)

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mammalian protein found in Homo sapiens
  • presenilin-1 isoform I-467
  • presenilin-1
  • Protein S182
  • PSEN1
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Language Label Description Also known as
English
Presenilin 1
mammalian protein found in Homo sapiens
  • presenilin-1 isoform I-467
  • presenilin-1
  • Protein S182
  • PSEN1

Statements

molecular function
protein binding
determination method or standard
IPI
13 references
retrieved
9 May 2019
stated in
Alzheimer's disease-associated ubiquilin-1 regulates presenilin-1 accumulation and aggresome formation
GOA
curator
UniProt
UniProt protein ID
P49768
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Presenilin 1 associates with glycogen synthase kinase-3beta and its substrate tau
GOA
curator
UniProt
UniProt protein ID
P49768
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Mammalian APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein and Notch
GOA
curator
UniProt
UniProt protein ID
P49768
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
X11 alpha and x11 beta interact with presenilin-1 via their PDZ domains
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Cellular localization of Nicastrin affects amyloid beta species production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interaction between amyloid precursor protein and presenilins in mammalian cells: implications for the pathogenesis of Alzheimer disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Interactome mapping suggests new mechanistic details underlying Alzheimer's disease
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Activation and intrinsic γ-secretase activity of presenilin 1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Autoinhibition of X11/Mint scaffold proteins revealed by the closed conformation of the PDZ tandem
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Intracellular trafficking of TREM2 is regulated by presenilin 1.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Identification of ubiquilin, a novel presenilin interactor that increases presenilin protein accumulation
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
retrieved
9 May 2019
stated in
Presenilin 1 suppresses the function of c-Jun homodimers via interaction with QM/Jif-1
GOA
curator
Critical Assessment of Protein Function Annotation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IPI
cell component
Golgi apparatus
determination method or standard
IDA
IEA
6 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P49768
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IEA
retrieved
9 May 2019
stated in
The presenilin 1 protein is a component of a high molecular weight intracellular complex that contains beta-catenin
GOA
curator
UniProt
UniProt protein ID
P49768
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IDA
retrieved
9 May 2019
stated in
Two homologous genes causing early-onset familial Alzheimer's disease
GOA
curator
Mouse Genome Informatics
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IDA
retrieved
9 May 2019
stated in
GOA
curator
Human Protein Atlas
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IDA
retrieved
9 May 2019
stated in
Purification and characterization of the human gamma-secretase complex
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IDA
biological process
learning or memory
determination method or standard
IEA
IGI
TAS
5 references
retrieved
9 May 2019
stated in
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
TAS
retrieved
9 May 2019
stated in
Memory impairment in transgenic Alzheimer mice requires cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IGI
retrieved
9 May 2019
stated in
Human LilrB2 is a β-amyloid receptor and its murine homolog PirB regulates synaptic plasticity in an Alzheimer's model
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IGI
retrieved
9 May 2019
stated in
Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49768
determination method or standard
IEA
Gene Atlas image
PBB GE PSEN1 203460 s at fs.png
732 × 530; 12 KB
0 references

Identifiers

Ensembl protein ID
 
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