signal transducer and activator of transcription 3 (Q4210010)

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mammalian protein found in Homo sapiens
  • DNA-binding protein APRF
  • STAT3 Transcription Factor
  • STAT3
  • acute-phase response factor
edit
Language Label Description Also known as
English
signal transducer and activator of transcription 3
mammalian protein found in Homo sapiens
  • DNA-binding protein APRF
  • STAT3 Transcription Factor
  • STAT3
  • acute-phase response factor

Statements

part of
molecular function
DNA-binding transcription factor activity
determination method
IDA
IEA
TAS
5 references
retrieved
9 May 2019
stated in
STAT3beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
TAS
retrieved
9 May 2019
stated in
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
protein binding
determination method
IPI
51 references
retrieved
9 May 2019
stated in
Tid1 isoforms are mitochondrial DnaJ-like chaperones with unique carboxyl termini that determine cytosolic fate
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Acetylation Directs Survivin Nuclear Localization to Repress STAT3 Oncogenic Activity
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Identification of STAT3 as a specific substrate of breast tumor kinase
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
The cell death regulator GRIM-19 is an inhibitor of signal transducer and activator of transcription 3
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Respiratory syncytial virus-inducible BCL-3 expression antagonizes the STAT/IRF and NF-kappaB signaling pathways by inducing histone deacetylase 1 recruitment to the interleukin-8 promoter
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
BART is essential for nuclear retention of STAT3
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Reactive Oxygen Species (ROS) Mediate p300-dependent STAT1 Protein Interaction with Peroxisome Proliferator-activated Receptor (PPAR)-γ in CD36 Protein Expression and Foam Cell Formation
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
JAK/STAT3 pathway is involved in survival of neurons in response to insulin-like growth factor and negatively regulated by suppressor of cytokine signaling-3
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Inositol Polyphosphate-5-Phosphatase F (INPP5F) inhibits STAT3 activity and suppresses gliomas tumorigenicity
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
MEN2A-RET-induced cellular transformation by activation of STAT3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
A quantitative protein interaction network for the ErbB receptors using protein microarrays
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
PTP1B regulates leptin signal transduction in vivo
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Novel role of signal transducer and activator of transcription 3 as a progesterone receptor coactivator in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
A proteome-scale map of the human interactome network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Next-generation sequencing to generate interactome datasets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
STAT3 regulates Nemo-like kinase by mediating its interaction with IL-6-stimulated TGFbeta-activated kinase 1 for STAT3 Ser-727 phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Implication of BRG1 and cdk9 in the STAT3-mediated activation of the p21waf1 gene
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Peroxiredoxin-2 and STAT3 form a redox relay for H2O2 signaling.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Phosphotyrosine signaling networks in epidermal growth factor receptor overexpressing squamous carcinoma cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Physical and functional interactions between STAT3 and Kaposi's sarcoma-associated herpesvirus-encoded LANA
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
ECHS1 interacts with STAT3 and negatively regulates STAT3 signaling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
SH2B1β interacts with STAT3 and enhances fibroblast growth factor 1-induced gene expression during neuronal differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Physical and functional interactions between Daxx and STAT3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
PIPINO: A Software Package to Facilitate the Identification of Protein-Protein Interactions from Affinity Purification Mass Spectrometry Data
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Mechanism of protein tyrosine phosphatase 1B-mediated inhibition of leptin signalling
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Progesterone receptor induces ErbB-2 nuclear translocation to promote breast cancer growth via a novel transcriptional effect: ErbB-2 function as a coactivator of Stat3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Crif1 is a novel transcriptional coactivator of STAT3
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Structural requirements for signal transducer and activator of transcription 3 binding to phosphotyrosine ligands containing the YXXQ motif
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
EGFR phosphorylates tumor-derived EGFRvIII driving STAT3/5 and progression in glioblastoma
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Differential activation of acute phase response factor/STAT3 and STAT1 via the cytoplasmic domain of the interleukin 6 signal transducer gp130. I. Definition of a novel phosphotyrosine motif mediating STAT1 activation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
A complex of nuclear factor I-X3 and STAT3 regulates astrocyte and glioma migration through the secreted glycoprotein YKL-40
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Construction and characterization of a normalized yeast two-hybrid library derived from a human protein-coding clone collection
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Epigenetic regulation of CpG promoter methylation in invasive prostate cancer cells
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
The role of the c-Jun N-terminal kinase 2-α-isoform in non-small cell lung carcinoma tumorigenesis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Human leptin signaling in human peripheral blood mononuclear cells: activation of the JAK-STAT pathway
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3.
GOA
curator
AgBase
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
identical protein binding
determination method
IEA
IPI
5 references
retrieved
9 May 2019
stated in
Dominant-negative mutations in the DNA-binding domain of STAT3 cause hyper-IgE syndrome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Toward an understanding of the protein interaction network of the human liver
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IPI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
cell component
cytoplasm
determination method
IDA
ISS
IEA
TAS
7 references
retrieved
9 May 2019
stated in
Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
TAS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
BART is essential for nuclear retention of STAT3
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
The Sin3a repressor complex is a master regulator of STAT transcriptional activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
nucleus
determination method
IDA
ISS
IEA
12 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
ISS
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
8 April 2019
stated in
BART is essential for nuclear retention of STAT3
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
8 April 2019
stated in
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
8 April 2019
stated in
Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
8 April 2019
stated in
The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
8 April 2019
stated in
The Sin3a repressor complex is a master regulator of STAT transcriptional activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
8 April 2019
stated in
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
8 April 2019
stated in
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
8 April 2019
stated in
β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
nucleus
determination method
IBA
IDA
IEA
ISS
13 references
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
ISS
retrieved
9 May 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
BART is essential for nuclear retention of STAT3
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling
GOA
curator
HUGO Gene Nomenclature Committee
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
The role of STAT3 in granulocyte colony-stimulating factor-induced enhancement of neutrophilic differentiation of Me2SO-treated HL-60 cells. GM-CSF inhibits the nuclear translocation of tyrosine-phosphorylated STAT3
GOA
curator
Community Assessment of Community Annotation with Ontologies
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
The Sin3a repressor complex is a master regulator of STAT transcriptional activity
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
β1,6 GlcNAc branches-modified PTPRT attenuates its activity and promotes cell migration by STAT3 pathway
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IBA
biological process
positive regulation of transcription by RNA polymerase II
determination method
IDA
IGI
IEA
IMP
6 references
retrieved
8 April 2019
stated in
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IMP
retrieved
8 April 2019
stated in
Interleukin-6 induces hepcidin expression through STAT3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IMP
retrieved
8 April 2019
stated in
Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IGI
retrieved
8 April 2019
stated in
Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IGI
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
8 April 2019
stated in
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
interleukin-6-mediated signaling pathway
determination method
IDA
IMP
TAS
7 references
retrieved
9 May 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
TAS
retrieved
9 May 2019
stated in
Interleukin-6 induces hepcidin expression through STAT3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IMP
retrieved
9 May 2019
stated in
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IMP
retrieved
9 May 2019
stated in
The nuclear isoform of protein-tyrosine phosphatase TC-PTP regulates interleukin-6-mediated signaling pathway through STAT3 dephosphorylation
GOA
curator
UniProt
UniProt protein ID
P40763
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
positive regulation of transcription by RNA polymerase II
determination method
IBA
IDA
IEA
IGI
IMP
7 references
retrieved
9 May 2019
stated in
Interleukin-6 induces hepcidin expression through STAT3
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IMP
retrieved
9 May 2019
stated in
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IMP
retrieved
9 May 2019
stated in
Hsp105beta upregulates hsp70 gene expression through signal transducer and activator of transcription-3
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IGI
retrieved
9 May 2019
stated in
Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis
GOA
curator
ARUK-UCL
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IGI
retrieved
9 May 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IEA
retrieved
9 May 2019
stated in
Interleukin-6 transcriptionally regulates prohibitin expression in intestinal epithelial cells
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IDA
retrieved
9 May 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P40763
determination method
IBA
Gene Atlas image
PBB GE STAT3 208991 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D050796
subject named as
STAT3 Transcription Factor
0 references
 
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