calcium sensing receptor (Q417801)

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mammalian protein found in Homo sapiens
  • extracellular calcium-sensing receptor
  • CASR
  • parathyroid Ca(2+)-sensing receptor 1
  • parathyroid cell calcium-sensing receptor 1
  • PCaR1
  • Receptors, Calcium-Sensing
edit
Language Label Description Also known as
English
calcium sensing receptor
mammalian protein found in Homo sapiens
  • extracellular calcium-sensing receptor
  • CASR
  • parathyroid Ca(2+)-sensing receptor 1
  • parathyroid cell calcium-sensing receptor 1
  • PCaR1
  • Receptors, Calcium-Sensing

Statements

molecular function
cell component
integral component of plasma membrane
determination method
IDA
TAS
9 references
retrieved
16 July 2018
stated in
Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
TAS
retrieved
16 July 2018
stated in
Identification and functional analysis of a novel CaSR mutation in a family with familial hypocalciuric hypercalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
16 July 2018
stated in
Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
16 July 2018
stated in
CASR gene activating mutations in two families with autosomal dominant hypocalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
16 July 2018
stated in
Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
16 July 2018
stated in
Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
16 July 2018
stated in
A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
16 July 2018
stated in
Novel activating mutation of human calcium-sensing receptor in a family with autosomal dominant hypocalcaemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
16 July 2018
stated in
Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=P41180&geneProductId=UniProtKB:P41180
determination method
IDA
integral component of plasma membrane
determination method
IBA
IDA
TAS
10 references
retrieved
8 April 2019
stated in
Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
TAS
retrieved
8 April 2019
stated in
Novel activating mutation of human calcium-sensing receptor in a family with autosomal dominant hypocalcaemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
Calcium-sensing receptor dimerizes in the endoplasmic reticulum: biochemical and biophysical characterization of CASR mutants retained intracellularly.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
Identification and functional analysis of a novel CaSR mutation in a family with familial hypocalciuric hypercalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
CASR gene activating mutations in two families with autosomal dominant hypocalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IBA
biological process
G protein-coupled receptor signaling pathway
determination method
IDA
IEA
IMP
TAS
18 references
retrieved
8 April 2019
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
TAS
retrieved
8 April 2019
stated in
Molecular cloning and functional expression of human parathyroid calcium receptor cDNAs
GOA
curator
Proteome Inc.
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
TAS
retrieved
8 April 2019
stated in
Clustered inactivating mutations and benign polymorphisms of the calcium receptor gene in familial benign hypocalciuric hypercalcemia suggest receptor functional domains
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Novel activating mutation of human calcium-sensing receptor in a family with autosomal dominant hypocalcaemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
A novel mutation in calcium-sensing receptor gene associated to hypercalcemia and hypercalciuria
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Neonatal severe hyperparathyroidism associated with a novel de novo heterozygous R551K inactivating mutation and a heterozygous A986S polymorphism of the calcium-sensing receptor gene.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Expression and characterization of inactivating and activating mutations in the human Ca2+o-sensing receptor
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Two novel mutations of the calcium-sensing receptor gene affecting the same amino acid position lead to opposite phenotypes and reveal the importance of p.N802 on receptor activity.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Identification and functional analysis of a novel CaSR mutation in a family with familial hypocalciuric hypercalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Functional characterization of calcium-sensing receptor mutations expressed in human embryonic kidney cells
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
A novel mutation in the calcium-sensing receptor in a French family with familial hypocalciuric hypercalcaemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Calcium-sensing-related gene mutations in hypercalcaemic hypocalciuric patients as differential diagnosis from primary hyperparathyroidism: detection of two novel inactivating mutations in an Italian population
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
CASR gene activating mutations in two families with autosomal dominant hypocalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
A novel loss-of-function mutation, Gln459Arg, of the calcium-sensing receptor gene associated with apparent autosomal recessive inheritance of familial hypocalciuric hypercalcemia
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
Loss-of-function and gain-of-function mutations of calcium-sensing receptor: functional analysis and the effect of allosteric modulators NPS R-568 and NPS 2143.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IMP
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IEA
retrieved
8 April 2019
stated in
Structural mechanism of ligand activation in human calcium-sensing receptor.
GOA
curator
UniProt
UniProt protein ID
P41180
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P41180
determination method
IDA
Gene Atlas image
PBB GE CASR 210577 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
D044169
subject named as
Receptors, Calcium-Sensing
0 references
 
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