Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins (Q41630321)

5 October 2017

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title

Inhibition of the Ser-Thr phosphatases PP1 and PP2A by naturally occurring toxins (English)

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5 October 2017

Sheppeck JE 2nd

1

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5 October 2017

Gauss CM

series ordinal

2

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5 October 2017

Chamberlin AR

series ordinal

3

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5 October 2017

language of work or name

English

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publication date

1 September 1997

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Bioorganic & Medicinal Chemistry

5 October 2017

published in

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5 October 2017

volume

5

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5 October 2017

issue

9

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5 October 2017

page(s)

1739-1750

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The structure and regulation of protein phosphatases

5 October 2017

cites work

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Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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Crystal Structure of the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

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Crystal structure of human protein tyrosine phosphatase 1B

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7 January 2021

A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus

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Serine/threonine protein phosphatases

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7 January 2021

The structure of protein phosphatase 2A is as highly conserved as that of protein phosphatase 1.

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7 January 2021

Molecular identification of I1PP2A, a novel potent heat-stable inhibitor protein of protein phosphatase 2A.

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Full activation of a nuclear species of protein phosphatase-1 by phosphorylation with protein kinase A and casein kinase-2.

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Molecular cloning of NIPP-1, a nuclear inhibitor of protein phosphatase-1, reveals homology with polypeptides involved in RNA processing

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Purification and characterization of two potent heat-stable protein inhibitors of protein phosphatase 2A from bovine kidney

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Regulation of protein serine-threonine phosphatase type-2A by tyrosine phosphorylation

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7 January 2021

Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1

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7 January 2021

X-ray structure of calcineurin inhibited by the immunophilin-immunosuppressant FKBP12-FK506 complex

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7 January 2021

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

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7 January 2021

An investigation of the substrate specificity of protein phosphatase 2C using synthetic peptide substrates; comparison with protein phosphatase 2A

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7 January 2021

Mechanism of inhibition of protein phosphatase 1 by DARPP-32: studies with recombinant DARPP-32 and synthetic peptides

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7 January 2021

The structure, role, and regulation of type 1 protein phosphatases

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7 January 2021

Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.

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7 January 2021

Cyanobacteria secondary metabolites-the cyanotoxins

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7 January 2021

The toxins of cyanobacteria

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7 January 2021

Identification of 12 hepatotoxins from a Homer Lake bloom of the cyanobacteria Microcystis aeruginosa, Microcystis viridis, and Microcystis wesenbergii: nine new microcystins

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7 January 2021

Poisonous Australian Lake

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7 January 2021

Structural studies on cyanoginosins-LR, -YR, -YA, and -YM, peptide toxins from Microcystis aeruginosa

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7 January 2021

Nodularin, microcystin, and the configuration of Adda

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7 January 2021

Motuporin, A Potent Protein Phosphatase Inhibitor Isolated from the Papua New Guinea Sponge Theonella swinhoei Gray

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7 January 2021

The effects of single L-amino acid substitutions on the lethal potencies of the microcystins

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7 January 2021

Monoclonal antibody specific for cyanoginosin-LA: preparation and characterization

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7 January 2021

Structural modifications imparting reduced toxicity in microcystins from Microcystis spp.

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7 January 2021

Isolation and characterization of the minor components associated with microcystins LR and RR in the cyanobacterium (blue-green algae).

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7 January 2021

Structures of three new cyclic heptapeptide hepatotoxins produced by the cyanobacterium (blue-green alga) Nostoc sp. strain 152

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7 January 2021

Isolation and characterization of hepatotoxic microcystin homologs from the filamentous freshwater cyanobacterium Nostoc sp. strain 152.

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7 January 2021

Three new microcystins, cyclic heptapeptide hepatotoxins, from Nostoc sp. strain 152

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7 January 2021

Seven More Microcystins from Homer Lake Cells: Application of the General Method for Structure Assignment of Peptides Containing .alpha.,.beta.-Dehydroamino Acid Unit(s)

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7 January 2021

Two new L-serine variants of microcystins-LR and -RR from Anabaena sp. strains 202 A1 and 202 A2

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7 January 2021

Berninamycin biosynthesis. 1. Origin of the dehydroalanine residues

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7 January 2021

Isolation of linear peptides related to the hepatotoxins nodularin and microcystins

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7 January 2021

Teurilene and thyrsiferyl 23-acetate, meso and remarkably cytotoxic compounds from the marine red alga laurencia obtusa (hudson) lamouroux

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7 January 2021

Thyrsiferyl 23-acetate is a novel specific inhibitor of protein phosphatase PP2A.

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7 January 2021

A fatal case of poisoning with cantharidin

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7 January 2021

Cantharidin poisoning associated with specific binding site in liver

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7 January 2021

Protein phosphatase 2A and its [3H]cantharidin/[3H]endothall thioanhydride binding site. Inhibitor specificity of cantharidin and ATP analogues

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7 January 2021

Cantharidin, another natural toxin that inhibits the activity of serine/threonine protein phosphatases types 1 and 2A.

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https://api.crossref.org/works/10.1016%2FS0968-0896%2897%2900146-6

7 January 2021

Inhibition of protein phosphatase 2A by cantharidin analogues

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7 January 2021

Endothall thioanhydride: structural aspects of unusually high mouse toxicity and specific binding site in liver

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7 January 2021

Okadaic acid, a cytotoxic polyether from two marine sponges of the genus Halichondria

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7 January 2021

Acanthifolicin, a new episulfide-containing polyether carboxylic acid from extracts of the marine sponge Pandaros acanthifolium

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7 January 2021

Inhibitory effect of okadaic acid derivatives on protein phosphatases. A study on structure-affinity relationship

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7 January 2021

Structure-activity relationship within a series of okadaic acid derivatives

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7 January 2021

Inhibition of protein phosphatases-1 and -2A with acanthifolicin

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7 January 2021

Identification of DTX-4, a new water-soluble phosphatase inhibitor from the toxic dinoflagellate Prorocentrum lima

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7 January 2021

Bioactive marine metabolites. Part 16. Calyculin A. A novel antitumor metabolite from the marine sponge Discodermia calyx

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7 January 2021

Bioactive marine metabolites. 24. Isolation and structure elucidation of calyculins B, C, and D, novel antitumor metabolites, from the marine sponge Discodermia calyx

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7 January 2021

Calyculin A and okadaic acid: inhibitors of protein phosphatase activity

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7 January 2021

Calyculins E, F, G, and H, additional inhibitors of protein phosphatases 1 and 2a, from the marine sponge discodermia calyx

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7 January 2021

Tumor promotion by inhibitors of protein phosphatases 1 and 2A: the okadaic acid class of compounds

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7 January 2021

A new antibiotic, tautomycin

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7 January 2021

The structure of tautomycin, a dialkylmaleic anhydride antibiotic

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7 January 2021

The structure of tautomycin, a regulator of eukaryotic cell growth

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7 January 2021

Tautomycin from the bacterium Streptomyces verticillatus

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7 January 2021

A novel protein phosphatase inhibitor, tautomycin. Effect on smooth muscle.

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7 January 2021

Structure-activity relationship within a series of degradation products of tautomycin

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7 January 2021

A new antibiotic, tautomycetin.

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7 January 2021

The structure of tautomycetin, a dialkylmaleic anhydride antibiotic

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7 January 2021

In vitro and in vivo effects of protein phosphatase inhibitors, microcystins and nodularin, on mouse skin and fibroblasts

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7 January 2021

Inhibition of protein phosphatases by microcystins and nodularin associated with hepatotoxicity

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7 January 2021

Cyanobacterial microcystin-LR is a potent and specific inhibitor of protein phosphatases 1 and 2A from both mammals and higher plants

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7 January 2021

Inhibition of specific binding of okadaic acid to protein phosphatase 2A by microcystin-LR, calyculin-A and tautomycin: method of analysis of interactions of tight-binding ligands with target protein

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7 January 2021

Dephosphorylation of phosphorylated atrial natriuretic peptide by protein phosphatase 2A.

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7 January 2021

Codon 61 mutations in the c-Harvey-ras gene in mouse skin tumors induced by 7,12-dimethylbenz[a]anthracene plus okadaic acid class tumor promoters

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7 January 2021

Is the inhibition of protein phosphatase 1 and 2A activities a general mechanism of tumor promotion in human cancer development?

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7 January 2021

Dephosphorylation of microtubule-associated protein tau by protein phosphatase-1 and -2C and its implication in Alzheimer disease.

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7 January 2021

Dephosphorylation of Alzheimer's disease abnormally phosphorylated tau by protein phosphatase-2A.

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7 January 2021

Phosphatase activity toward abnormally phosphorylated tau: decrease in Alzheimer disease brain.

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7 January 2021

A68: a major subunit of paired helical filaments and derivatized forms of normal Tau.

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7 January 2021

Proline-directed and non-proline-directed phosphorylation of PHF-tau.

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7 January 2021

Protein studies try to puzzle out Alzheimer's tangles.

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7 January 2021

10.1016/S0968-0896(97)00146-6

Identifiers

DOI

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5 October 2017

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