cytochrome P450 family 19 subfamily A member 1 (Q415287)

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mammalian protein found in Homo sapiens

• cytochrome P450, subfamily XIX (aromatization of androgens)
• flavoprotein-linked monooxygenase
• cytochrome P-450AROM
• estrogen synthetase
• microsomal monooxygenase
• aromatase
• estrogen synthase
• cytochrome P450, family 19, subfamily A, polypeptide 1
• CYPXIX
• CYP19A1
• cytochrome P450 19A1

edit

Language	Label	Description	Also known as
English	cytochrome P450 family 19 subfamily A member 1	mammalian protein found in Homo sapiens	cytochrome P450, subfamily XIX (aromatization of androgens) flavoprotein-linked monooxygenase cytochrome P-450AROM estrogen synthetase microsomal monooxygenase aromatase estrogen synthase cytochrome P450, family 19, subfamily A, polypeptide 1 CYPXIX CYP19A1 cytochrome P450 19A1

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11511

subclass of

enzyme

0 references

part of

cytochrome P450 superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P11511

cytochrome P450, E-class, group I

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P11511

cytochrome P450, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11511

encoded by

CYP19A1

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11511

molecular function

iron ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

oxygen binding

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

metal ion binding

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

monooxygenase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

heme binding

determination method or standard

IDA

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

retrieved

8 April 2019

stated in

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IDA

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

electron transfer activity

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

oxidoreductase activity

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

aromatase activity

determination method or standard

IDA

2 references

retrieved

8 April 2019

stated in

Structural basis for androgen specificity and oestrogen synthesis in human aromatase

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IDA

retrieved

8 April 2019

stated in

Osteopontin promotes aromatase expression and estradiol production in human adipocytes

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IDA

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Biochemical and molecular genetic analyses on placental aromatase (P-450AROM) deficiency

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

steroid hydroxylase activity

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

cell component

endoplasmic reticulum membrane

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

endoplasmic reticulum

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

LifeDB

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IDA

membrane

determination method or standard

TAS

IEA

2 references

retrieved

8 April 2019

stated in

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

P11511

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

biological process

estrogen biosynthetic process

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

androgen metabolic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

negative regulation of chronic inflammatory response

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

prostate gland growth

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

sterol metabolic process

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

negative regulation of macrophage chemotaxis

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

steroid biosynthetic process

determination method or standard

TAS

1 reference

retrieved

8 April 2019

stated in

Isolation of a full-length cDNA insert encoding human aromatase system cytochrome P-450 and its expression in nonsteroidogenic cells

GOA

curator

Proteome Inc.

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

TAS

female gonad development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

female genitalia development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

mammary gland development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

uterus development

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

testosterone biosynthetic process

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Ensembl genome database project

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

androgen catabolic process

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Osteopontin promotes aromatase expression and estradiol production in human adipocytes

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IDA

positive regulation of estradiol secretion

determination method or standard

IDA

1 reference

retrieved

8 April 2019

stated in

Osteopontin promotes aromatase expression and estradiol production in human adipocytes

GOA

curator

Critical Assessment of Protein Function Annotation

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IDA

electron transport chain

determination method or standard

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P11511

determination method or standard

IEA

physically interacts with

(RS)-aminoglutethimide

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7054

language of work or name

English

retrieved

17 August 2016

anastrozole

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5137

language of work or name

English

retrieved

17 August 2016

azalanstat

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8799

language of work or name

English

retrieved

17 August 2016

exemestane

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7073

language of work or name

English

retrieved

17 August 2016

fadrozole

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

8311

language of work or name

English

retrieved

17 August 2016

letrozole

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

5209

language of work or name

English

retrieved

17 August 2016

testolactone

has use

enzyme inhibitor

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

7303

language of work or name

English

retrieved

17 August 2016

Gene Atlas image

PBB GE PGR 208305 at tn.png
255 × 135; 896 bytes

1 reference

imported from Wikimedia project

English Wikipedia

exact match

http://purl.uniprot.org/uniprot/P11511

1 reference

stated in

Identifiers.org

has part(s)

cytochrome P450, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/P11511

Commons category

Aromatase

0 references

Identifiers

RefSeq protein ID

NP_000094

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334177

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334178

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334179

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334180

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334181

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334182

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334183

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334184

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_001334185

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

NP_112503

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

1588

UniProt protein ID

P11511

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

P11511

Ensembl protein ID

ENSP00000379683

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379683

ENSP00000379685

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000379685

ENSP00000383930

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000383930

ENSP00000452627

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000452627

ENSP00000453149

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453149

ENSP00000384389

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000384389

ENSP00000390614

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000390614

ENSP00000391139

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000391139

ENSP00000452667

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000452667

ENSP00000452872

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000452872

ENSP00000453280

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453280

ENSP00000453318

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000453318

ENSP00000454004

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000454004

ENSP00000454039

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000454039

ENSP00000479587

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000479587

Freebase ID

/m/04_nqj

1 reference

stated in

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

2776166826

0 references

OpenAlex ID

C2776166826

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

3EQM

1 reference

stated in

UniProt

UniProt protein ID

P11511

retrieved

15 June 2016

language of work or name

English

3S79

1 reference

stated in

UniProt

UniProt protein ID

P11511

retrieved

15 June 2016

language of work or name

English

3S7S

1 reference

stated in

UniProt

UniProt protein ID

P11511

retrieved

15 June 2016

language of work or name

English

4GL5

1 reference

stated in

UniProt

UniProt protein ID

P11511

retrieved

15 June 2016

language of work or name

English

4GL7

1 reference

stated in

UniProt

UniProt protein ID

P11511

retrieved

15 June 2016

language of work or name

English

4KQ8

1 reference

stated in

UniProt

UniProt protein ID

P11511

retrieved

15 June 2016

language of work or name

English

YSO ID

38965

1 reference

stated in

YSO-Wikidata mapping project

retrieved

15 September 2023

 

Sitelinks

Wikipedia(28 entries)

edit

• arwiki أروماتاز
• bswiki Aromataza
• cawiki Aromatasa
• cywiki CYP19A1
• dawiki Aromatase
• dewiki Aromatase
• enwiki Aromatase
• eswiki Aromatasa
• euwiki Aromatasa
• fawiki آروماتاز
• fiwiki Aromataasi
• frwiki Aromatase
• glwiki Aromatase
• hewiki ארומטאז
• idwiki Aromatase
• itwiki Aromatasi
• jawiki アロマターゼ
• kowiki 방향화효소
• lawiki Aromatasis
• mkwiki Ароматаза
• nlwiki Aromatase
• plwiki Aromataza
• ptwiki Aromatase
• ruwiki Ароматаза
• srwiki Ароматаза
• svwiki Aromatas
• ukwiki CYP19A1
• zhwiki 芳香化酶

Wikibooks(0 entries)

edit

Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

edit

Wiktionary(0 entries)

edit

Multilingual sites(1 entry)

edit

• commonswiki Category:Aromatase

Retrieved from "https://www.wikidata.org/w/index.php?title=Q415287&oldid=2233526952"