How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication. (Q41072353)

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30 March 2020

title

How the Eukaryotic Replisome Achieves Rapid and Efficient DNA Replication (English)

1 reference

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John Francis Xavier Diffley

30 March 2020

author

4

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30 March 2020

author name string

Joseph T P Yeeles

1

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30 March 2020

Agnieska Janska

2

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30 March 2020

Anne Early

3

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publication date

15 December 2016

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30 March 2020

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30 March 2020

volume

65

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issue

1

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page(s)

105-116

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Chromatin Controls DNA Replication Origin Selection, Lagging-Strand Synthesis, and Replication Fork Rates

30 March 2020

cites work

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Phosphopeptide binding by Sld3 links Dbf4-dependent kinase to MCM replicative helicase activation

26 September 2017

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Recruitment of Mcm10 to Sites of Replication Initiation Requires Direct Binding to the Minichromosome Maintenance (MCM) Complex

26 September 2017

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A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands

26 September 2017

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Reconstitution of a eukaryotic replisome reveals suppression mechanisms that define leading/lagging strand operation.

26 September 2017

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A global profile of replicative polymerase usage

26 September 2017

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Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation.

26 September 2017

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CMG helicase and DNA polymerase ε form a functional 15-subunit holoenzyme for eukaryotic leading-strand DNA replication.

26 September 2017

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Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.

26 September 2017

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Helicase activation and establishment of replication forks at chromosomal origins of replication.

26 September 2017

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High-resolution mapping, characterization, and optimization of autonomously replicating sequences in yeast.

26 September 2017

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Mcm10 associates with the loaded DNA helicase at replication origins and defines a novel step in its activation

26 September 2017

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GINS motion reveals replication fork progression is remarkably uniform throughout the yeast genome.

26 September 2017

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A double-hexameric MCM2-7 complex is loaded onto origin DNA during licensing of eukaryotic DNA replication

26 September 2017

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Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing

26 September 2017

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Csm3, Tof1, and Mrc1 form a heterotrimeric mediator complex that associates with DNA replication forks

26 September 2017

1 reference

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A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome.

26 September 2017

1 reference

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The direct binding of Mrc1, a checkpoint mediator, to Mcm6, a replication helicase, is essential for the replication checkpoint against methyl methanesulfonate-induced stress

26 September 2017

1 reference

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Mrc1 and DNA polymerase epsilon function together in linking DNA replication and the S phase checkpoint

26 September 2017

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Division of labor at the eukaryotic replication fork

26 September 2017

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Claspin promotes normal replication fork rates in human cells

26 September 2017

1 reference

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The eukaryotic leading and lagging strand DNA polymerases are loaded onto primer-ends via separate mechanisms but have comparable processivity in the presence of PCNA.

26 September 2017

1 reference

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Mrc1 and Tof1 regulate DNA replication forks in different ways during normal S phase

26 September 2017

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Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells

26 September 2017

1 reference

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Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.

26 September 2017

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CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeast

26 September 2017

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Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase

26 September 2017

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Distinct roles for Sld3 and GINS during establishment and progression of eukaryotic DNA replication forks

26 September 2017

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GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks

26 September 2017

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The Tof1p-Csm3p protein complex counteracts the Rrm3p helicase to control replication termination of Saccharomyces cerevisiae

26 September 2017

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Mrc1 and Tof1 promote replication fork progression and recovery independently of Rad53.

26 September 2017

1 reference

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Molecular anatomy and regulation of a stable replisome at a paused eukaryotic DNA replication fork.

26 September 2017

1 reference

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Mcm10 regulates the stability and chromatin association of DNA polymerase-alpha.

26 September 2017

1 reference

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swi1- and swi3-dependent and independent replication fork arrest at the ribosomal DNA of Schizosaccharomyces pombe

26 September 2017

1 reference

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S-phase checkpoint proteins Tof1 and Mrc1 form a stable replication-pausing complex

26 September 2017

1 reference

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In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase epsilon in insect cells. Purification and characterization

26 September 2017

1 reference

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Cell-Cycle-Regulated Interaction between Mcm10 and Double Hexameric Mcm2-7 Is Required for Helicase Splitting and Activation during S Phase

26 September 2017

1 reference

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Regulated eukaryotic DNA replication origin firing with purified proteins

26 September 2017

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Intrinsic coupling of lagging-strand synthesis to chromatin assembly.

14 June 2018

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DNA polymerase epsilon catalytic domains are dispensable for DNA replication, DNA repair, and cell viability

14 June 2018

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Coordinated leading and lagging strand synthesis during SV40 DNA replication in vitro requires PCNA.

14 June 2018

1 reference

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Strand-specific analysis shows protein binding at replication forks and PCNA unloading from lagging strands when forks stall

14 June 2018

1 reference

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Dpb2 integrates the leading-strand DNA polymerase into the eukaryotic replisome

19 August 2018

1 reference

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Ctf4 coordinates the progression of helicase and DNA polymerase alpha.

19 August 2018

1 reference

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Localization of MCM2-7, Cdc45, and GINS to the site of DNA unwinding during eukaryotic DNA replication.

19 August 2018

1 reference

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Mrc1 is required for normal progression of replication forks throughout chromatin in S. cerevisiae.

19 August 2018

1 reference

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swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S. pombe.

19 August 2018

1 reference

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10.1016/J.MOLCEL.2016.11.017

19 August 2018

Identifiers

DOI

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30 March 2020

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30 March 2020

PubMed publication ID

27989442

1 reference