Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact. (Q40874319)

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12 October 2019

review article

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title

Antiviral agents: characteristic activity spectrum depending on the molecular target with which they interact (English)

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12 October 2019

Antiviral Agents: Characteristic Activity Spectrum Depending on the Molecular Target With Which They Interact (English)

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Erik De Clercq

1

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author name string

De Clercq E

series ordinal

1

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12 October 2019

publication date

1 January 1993

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Advances in Virus Research

12 October 2019

1993

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published in

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12 October 2019

volume

42

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12 October 2019

page(s)

1-55

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Antiherpes virus activity and effect on deoxyribonucleoside triphosphate pools of (E)-5-(2-bromovinyl)-2'-deoxycytidine in combination with deaminase inhibitors

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7 January 2021

Synthesis and anti-HIV activity of different sugar-modified pyrimidine and purine nucleosides

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7 January 2021

Cellular pharmacology of 2',3'-dideoxy-2',3'-didehydrothymidine, a nucleoside analog active against human immunodeficiency virus

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7 January 2021

Inhibitory effect of selected antiviral compounds on measles (SSPE) virus replication in vitro

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7 January 2021

Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitro

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7 January 2021

In vitro activity of mannan sulfate, a novel sulfated polysaccharide, against human immunodeficiency virus type 1 and other enveloped viruses

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7 January 2021

In vitro anti-HIV-1 activity of chondroitin polysulphate

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7 January 2021

Inhibition of HIV-1 infectivity with curdlan sulfate in vitro

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7 January 2021

Inhibitory effects of antiviral compounds on respiratory syncytial virus replication in vitro

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7 January 2021

Mechanism of HIV reverse transcriptase: enzyme-primer interaction as revealed through studies of a dNTP analogue, 3'-azido-dTTP.

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7 January 2021

Potential anti-AIDS drugs. 2',3'-Dideoxycytidine analogues

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7 January 2021

Broad-spectrum antiviral activity of 2-beta-D-ribofuranosylselenazole-4-carboxamide, a new antiviral agent

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7 January 2021

Azidothymidine triphosphate is an inhibitor of both human immunodeficiency virus type 1 reverse transcriptase and DNA polymerase gamma

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7 January 2021

Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by the dipyridodiazepinone BI-RG-587

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7 January 2021

Treatment of latent rabbit and human papillomavirus infections with 9-(2-phosphonylmethoxy)ethylguanine (PMEG)

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7 January 2021

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin- 2(1H)-one (TIBO) derivatives

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7 January 2021

Synthesis and anti-HIV-1 activity of 4,5,6,7-tetrahydro-5-methylimidazo[4,5,1-jk][1,4]benzodiazepin-2(1H)-on e (TIBO) derivatives. 2

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7 January 2021

Zidovudine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy

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7 January 2021

Multiple mutations in HIV-1 reverse transcriptase confer high-level resistance to zidovudine (AZT)

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7 January 2021

HIV with reduced sensitivity to zidovudine (AZT) isolated during prolonged therapy

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7 January 2021

9-(3,4-dihydroxybutyl)guanine, a new inhibitor of herpesvirus multiplication

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Mode of action, toxicity, pharmacokinetics, and efficacy of some new antiherpesvirus guanosine analogs related to buciclovir

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7 January 2021

In vitro and in vivo comparison of the abilities of purine and pyrimidine 2',3'-dideoxynucleosides to inhibit duck hepadnavirus

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7 January 2021

Novel acyclic adenosine analogs inhibit Epstein-Barr virus replication

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7 January 2021

Antiviral activity of 2',3'-dideoxycytidin-2'-ene (2',3'-dideoxy-2',3'-didehydrocytidine) against human immunodeficiency virus in vitro

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7 January 2021

Synthesis and antiviral activity of various 3'-azido analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1, HTLV-III/LAV).

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Antiherpesviral and anticellular effects of 1-beta-D-arabinofuranosyl-E-5-(2-halogenovinyl) uracils

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7 January 2021

Inhibitory effects of antiherpesviral thymidine analogs against varicella-zoster virus

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7 January 2021

Synthesis and antiviral evaluation of 6'-substituted aristeromycins: potential mechanism-based inhibitors of S-adenosylhomocysteine hydrolase

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7 January 2021

1-(2,3-Dideoxy-beta-D-glycero-pent-2-enofuranosyl)thymine. A highly potent and selective anti-HIV agent

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7 January 2021

Cyclopentenylcytosine. A carbocyclic nucleoside with antitumor and antiviral properties

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Synthesis and antiviral activity of monofluoro and difluoro analogues of pyrimidine deoxyribonucleosides against human immunodeficiency virus (HIV-1)

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7 January 2021

The design, synthesis and antileukemic activity of 5-alkynyl-1-beta-D-ribofuranosylimidazole-4-carboxamides

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7 January 2021

Potent inhibition of hepatitis B virus production in vitro by modified pyrimidine nucleosides

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7 January 2021

Identification of small DNA fragments synthesized in herpes simplex virus-infected cells in the presence of acyclovir

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7 January 2021

Inhibition of HIV-1 Replication by a Nonnucleoside Reverse Transcriptase Inhibitor

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7 January 2021

Inhibition of herpes simplex virus DNA polymerase by diphosphates of acyclic phosphonylmethoxyalkyl nucleotide analogues

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7 January 2021

Nucleosides and nucleotides. 96. Synthesis and antitumor activity of 5-ethynyl-1-beta-D-ribofuranosylimidazole-4-carboxamide (EICAR) and its derivatives

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7 January 2021

Inhibition of the in vitro infectivity and cytopathic effect of human T-lymphotrophic virus type III/lymphadenopathy-associated virus (HTLV-III/LAV) by 2',3'-dideoxynucleosides

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Inhibition of infectivity and replication of HIV-2 and SIV in helper T-cells by 2',3'-dideoxynucleosides in vitro

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7 January 2021

Suramin protection of T cells in vitro against infectivity and cytopathic effect of HTLV-III.

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3'-Azido-3'-deoxythymidine (BW A509U): an antiviral agent that inhibits the infectivity and cytopathic effect of human T-lymphotropic virus type III/lymphadenopathy-associated virus in vitro

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7 January 2021

Dextran sulfate suppression of viruses in the HIV family: inhibition of virion binding to CD4+ cells

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7 January 2021

A novel lead for specific anti-HIV-1 agents: 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

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7 January 2021

Carbocyclic analogue of 3-deazaadenosine: a novel antiviral agent using S-adenosylhomocysteine hydrolase as a pharmacological target

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7 January 2021

Virazole (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide; a cytostatic agent.

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7 January 2021

Single-dose administration of 9-(2-phosphonylmethoxyethyl)adenine (PMEA) and 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) in the prophylaxis of retrovirus infection in vivo

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7 January 2021

Anti-HIV activity of dextran sulphate as determined under different experimental conditions

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7 January 2021

9-(trans-2',trans-3'-dihydroxycyclopent-4'-enyl) derivatives of adenine and 3-deazaadenine: potent inhibitors of bovine liver S-adenosylhomocysteine hydrolase

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7 January 2021

Computer-assisted structure-activity correlations of dideoxynucleoside analogs as potential anti-HIV drugs

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7 January 2021

Selective inhibition of human cytomegalovirus DNA synthesis by (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] and 9-(1,3-dihydroxy-2-propoxymethyl)guanine (DHPG).

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7 January 2021

Particular characteristics of the anti-human cytomegalovirus activity of (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) in vitro

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7 January 2021

Selective inhibition of human cytomegalovirus replication by a novel nucleoside, oxetanocin G.

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7 January 2021

Cyclobut-A and cyclobut-G: broad-spectrum antiviral agents with potential utility for the therapy of AIDS

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7 January 2021

Antiviral effects of phosphonoformate (PFA, foscarnet sodium)

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7 January 2021

Induction of Endogenous Virus and of Thymidine Kinase by Bromodeoxyuridine in Cell Cultures Transformed by Friend Virus

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7 January 2021

Cellular uptake of phosphonylmethoxyalkylpurine derivatives

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7 January 2021

Phosphonylmethoxyethyl purine derivatives, a new class of anti-human immunodeficiency virus agents

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7 January 2021

Potent and selective inhibition of HIV-1 replication in vitro by a novel series of TIBO derivatives

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7 January 2021

In vitro and in vivo evidence that the antiviral activity of 2',3'-dideoxycytidine is target cell dependent in a feline retrovirus animal model

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7 January 2021

Antiviral action and selectivity of 6-azauridine

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7 January 2021

BI-RG-587 is active against zidovudine-resistant human immunodeficiency virus type 1 and synergistic with zidovudine

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7 January 2021

Metabolism and action of neplanocin A in Chinese hamster ovary cells

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7 January 2021

9-(2-Hydroxyethoxymethyl)guanine activity against viruses of the herpes group

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7 January 2021

Mutations that confer resistance to mycophenolic acid and ribavirin on sindbis virus map to the nonstructural protein nsP1

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7 January 2021

Specific interaction of aurintricarboxylic acid with the human immunodeficiency virus/CD4 cell receptor

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7 January 2021

Syncytium formation and destruction of bystander CD4+ cells cocultured with T cells persistently infected with human immunodeficiency virus as demonstrated by flow cytometry

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7 January 2021

Flow cytometric method to monitor the destruction of CD4+ cells following their fusion with HIV-infected cells

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7 January 2021

Dextran sulfate and other polyanionic anti-HIV compounds specifically interact with the viral gp120 glycoprotein expressed by T-cells persistently infected with HIV-1.

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7 January 2021

Inhibition of influenza RNA synthesis by virazole (ribavirin)

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7 January 2021

Resolution of racemic carbocyclic analogues of purine nucleosides through the action of adenosine deaminase. Antiviral activity of the carbocyclic 2'-deoxyguanosine enantiomers

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7 January 2021

Inhibition of infectivity of human immunodeficiency virus by a novel nucleoside, oxetanocin, and related compounds

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7 January 2021

Selective inhibition of RNA tumor virus replication in vitro and evaluation of candidate antiviral agents in vivo

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7 January 2021

Evaluation of carbodine, the carbocyclic analog of cytidine, and related carbocyclic analogs of pyrimidine nucleosides for antiviral activity against human influenza Type A viruses

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7 January 2021

Comparative efficacy of antiherpes drugs against various strains of varicella-zoster virus

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7 January 2021

Comparative activities of several nucleoside analogs against influenza A, B, and C viruses in vitro

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7 January 2021

Lipophilic halogenated congeners of 2',3'-dideoxypurine nucleosides active against human immunodeficiency virus in vitro

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7 January 2021

Broad-spectrum antiviral activity of Virazole: 1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide

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7 January 2021

Activity of selenazofurin against influenza A and B viruses in vitro

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7 January 2021

(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine, a potent and selective inhibitor of human cytomegalovirus replication

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7 January 2021

Evaluation of infrequent dosing regimens with (S)-1-[3-hydroxy-2-(phosphonylmethoxy)propyl]-cytosine (S-HPMPC) on simian varicella infection in monkeys

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7 January 2021

Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2'-deoxy-3'-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog

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7 January 2021

3'-Azido-3'-deoxythymidine triphosphate as an inhibitor and substrate of purified human immunodeficiency virus reverse transcriptase

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7 January 2021

Incorporation into nucleic acids of the antiherpes guanosine analog buciclovir, and effects on DNA and protein synthesis

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7 January 2021

Synthesis and anti-HIV activity of several 2'-fluoro-containing pyrimidine nucleosides

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7 January 2021

Mechanism of action of 1- -D-ribofuranosyl-1,2,4-triazole-3-carboxamide (Virazole), a new broad-spectrum antiviral agent

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7 January 2021

A new class of HIV-1-specific 6-substituted acyclouridine derivatives: synthesis and anti-HIV-1 activity of 5- or 6-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

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7 January 2021

Synthesis and anti-HIV activity of 2-, 3-, and 4-substituted analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine (HEPT)

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7 January 2021

Specific anti-HIV-1 "acyclonucleosides" which cannot be phosphorylated: synthesis of some deoxy analogues of 1-[(2-hydroxyethoxy)methyl]-6-(phenylthio)thymine

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7 January 2021

Broad-spectrum antiviral activity of the acyclic guanosine phosphonate (R,S)-HPMPG.

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7 January 2021

Antiviral effects of 3'-azido-3'-deoxythymidine, 2',3'-dideoxycytidine, and 2',3'-dideoxyadenosine against simian acquired immunodeficiency syndrome-associated type D retrovirus in vitro

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7 January 2021

Synthesis of 3-deazaneplanocin A, a powerful inhibitor of S-adenosylhomocysteine hydrolase with potent and selective in vitro and in vivo antiviral activities

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7 January 2021

A ring-enlarged oxetanocin A analogue as an inhibitor of HIV infectivity

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7 January 2021

Dextran sulphate, a potent anti-HIV agent in vitro having synergism with zidovudine

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7 January 2021

Synthesis and antiviral activity evaluation of 3'-fluoro-3'-deoxyribonucleosides: broad-spectrum antiviral activity of 3'-fluoro-3'-deoxyadenosine.

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7 January 2021

Potent and selective activity of a new carbocyclic nucleoside analog (carbovir: NSC 614846) against human immunodeficiency virus in vitro

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7 January 2021

Properties of a 9-(2-phosphonylmethoxyethyl)adenine (PMEA)-resistant herpes simplex virus type 1 virus mutant

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7 January 2021

2-Methylpropyl ester of 3-(adenin-9-yl)-2-hydroxypropanoic acid. Mechanism of antiviral action in vaccinia virus-infected L929 cells

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7 January 2021

Effects of 2?,3?-dideoxynucleosides on mammalian cells and viruses

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Synthesis and anti-HIV-1 activity of 2'-"up"-fluoro analogs of active anti-AIDS nucleosides 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (DDC)

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7 January 2021

Sulphoevernan, a polyanionic polysaccharide, and the narcissus lectin potently inhibit human immunodeficiency virus infection by binding to viral envelope protein

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7 January 2021

A TIBO derivative, R82913, is a potent inhibitor of HIV-1 reverse transcriptase with heteropolymer templates

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7 January 2021

Synthesis and antiviral activity of 5-heteroaryl-substituted 2'-deoxyuridines

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7 January 2021

5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication

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Effect of ribavirin triphosphate on primer generation and elongation during influenza virus transcription in vitro

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7 January 2021

A novel dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site

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7 January 2021

Comparative activities of several nucleoside analogs against duck hepatitis B virus in vitro

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7 January 2021

Inhibitory effects of selected antiviral compounds on human hepatitis B virus DNA synthesis

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Sulfation of the immunomodulating polysaccharide lentinan: A novel strategy for antivirals to human immunodeficiency virus (HIV)

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7 January 2021

Dextran sulfate blocks antibody binding to the principal neutralizing domain of human immunodeficiency virus type 1 without interfering with gp120-CD4 interactions

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Inhibition of herpes simplex virus-induced DNA polymerase activity and viral DNA replication by 9-(2-hydroxyethoxymethyl)guanine and its triphosphate

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Inhibition of duck hepatitis B virus replication by 2',3'-dideoxycytidine. A potent inhibitor of reverse transcriptase

1 reference

https://api.crossref.org/works/10.1016%2FS0065-3527%2808%2960082-2

7 January 2021

10.1016/S0065-3527(08)60082-2

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