Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types (Q40763810)

23 September 2017

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title

Molecular pathogenesis of cancer of the cervix and its causation by specific human papillomavirus types (English)

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23 September 2017

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1

H zur Hausen

1 reference

23 September 2017

publication date

1 January 1994

1 reference

Current Topics in Microbiology and Immunology

23 September 2017

published in

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23 September 2017

volume

186

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23 September 2017

page(s)

131-156

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Transcription of human papillomavirus type 16 early genes in a cervical cancer and a cancer-derived cell line and identification of the E7 protein

23 September 2017

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Human Papillomaviruses and Their Possible Role in Squamous Cell Carcinomas

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Suppression of tumorigenicity in somatic cell hybrids. III. Cosegregation of human chromosome 11 of a normal cell and suppression of tumorigenicity in intraspecies hybrids of normal diploid x malignant cells.

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Transcription of the transforming genes of the oncogenic human papillomavirus-16 is stimulated by tumor promotors through AP1 binding sites

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11 October 2022

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HLA antigens and cervical carcinoma

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11 October 2022

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Transcription of the E6 and E7 genes of human papillomavirus type 6 in anogenital condylomata is restricted to undifferentiated cell layers of the epithelium

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11 October 2022

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The effect of DNA methylation on gene regulation of human papillomaviruses.

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Deficiency of all or part of chromosome 11 in several types of cancer: significance of a reduction in the number of normal chromosomes 11

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11 October 2022

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Modulation of the human papillomavirus type 16 induced transformation and transcription by deletion of loci on the short arm of human chromosome 11 can be mimicked by SV40 small t

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11 October 2022

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Progression of human papillomavirus type 18-immortalized human keratinocytes to a malignant phenotype

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11 October 2022

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Cytogenetic findings in cervical carcinoma. A statistical approach

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11 October 2022

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Constitutive release of IL6 by human papillomavirus type 16 (HPV16)-harboring keratinocytes: a mechanism augmenting the NK-cell-mediated lysis of HPV-bearing neoplastic cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Chromatin structure and transcriptional regulation of human papillomavirus type 18 DNA in HeLa cells.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Cell-heritable stages of tumor progression in transgenic mice harboring the bovine papillomavirus type 1 genome

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Structure and transcription of human papillomavirus sequences in cervical carcinoma cells

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

A member of the activator protein 1 family found in keratinocytes but not in fibroblasts required for transcription from a human papillomavirus type 18 promoter

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

E2F: a link between the Rb tumor suppressor protein and viral oncoproteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Association of human papillomavirus types 16 and 18 E6 proteins with p53.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

The physical state of human papillomavirus type 16 DNA in benign and malignant genital tumours

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

A new type of papillomavirus DNA, its presence in genital cancer biopsies and in cell lines derived from cervical cancer

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

The T/E1A-binding domain of the retinoblastoma product can interact selectively with a sequence-specific DNA-binding protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Linkage of regression and malignant conversion of rabbit viral papillomas to MHC class II genes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Defects in a cell cycle checkpoint may be responsible for the genomic instability of cancer cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Both episomal and integrated forms of human papillomavirus type 16 are involved in invasive cervical cancers

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Activation of human papillomavirus type 18 E6-E7 oncogene expression by transcription factor Sp1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Transactivation of a bovine papilloma virus transcriptional regulatory element by the E2 gene product

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Cancer. p53, guardian of the genome

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Regions of human papillomavirus type 16 E7 oncoprotein required for immortalization of human keratinocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Control of protein phosphatase 2A by simian virus 40 small-t antigen

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomavirus type 16 and 18 gene expression in cervical neoplasias

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Inhibition of tumorigenicity of cervical cancer cells in nude mice by HPV e6‐e7 anti‐sense RNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Repression of the human papillomavirus type 18 enhancer by the cellular transcription factor Oct-1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomaviruses in the pathogenesis of anogenital cancer

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

The E6/E7 promoter of human papillomavirus type 16 is activated in the absence of E2 proteins by a sequence-aberrant Sp1 distal element

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Cell-type-specific activity of the human papillomavirus type 18 upstream regulatory region in transgenic mice and its modulation by tetradecanoyl phorbol acetate and glucocorticoids

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Progesterone and glucocorticoid response elements occur in the long control regions of several human papillomaviruses involved in anogenital neoplasia

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Identification of a negative regulatory domain in the human papillomavirus type 18 promoter: interaction with the transcriptional repressor YY1

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Suppression in vivo of human papillomavirus type 18 E6-E7 gene expression in nontumorigenic HeLa X fibroblast hybrid cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Influence of chromosomal integration on glucocorticoid-regulated transcription of growth-stimulating papillomavirus genes E6 and E7 in cervical carcinoma cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Continued expression of HPV-16 E7 protein is required for maintenance of the transformed phenotype of cells co-transformed by HPV-16 plus EJ-ras.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Histopathologic and cytophotometric study of dysplastic and precancerous condyloma acuminata(author's transl)

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Identification and characterization of novel promoters in the genome of human papillomavirus type 18.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Tumor-suppressive effect of the retinoic acid receptor beta in human epidermoid lung cancer cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Immortalization of normal human oral keratinocytes with type 16 human papillomavirus

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Normal human chromosome 11 suppresses tumorigenicity of human cervical tumor cell line SiHa

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Comparison of the binding of the human papillomavirus type 16 and cottontail rabbit papillomavirus E7 proteins to the retinoblastoma gene product

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Retinoic acid-mediated repression of human papillomavirus 18 transcription and different ligand regulation of the retinoic acid receptor beta gene in non-tumorigenic and tumorigenic HeLa hybrid cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

A transcriptional repressor encoded by BPV-1 shares a common carboxy-terminal domain with the E2 transactivator.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Chromosomal characterizations of human nasal and nasopharyngeal cells immortalized by human papillomavirus type 16 DNA

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Regulation of human papillomavirus type 16 (HPV-16) transcription by loci on the short arm of chromosome 11 is mediated by the TATAAAA motif of the HPV-16 promoter

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papilloma virus DNAs immortalize normal human mammary epithelial cells and reduce their growth factor requirements

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Numerous nuclear proteins bind the long control region of human papillomavirus type 16: a subset of 6 of 23 DNase I-protected segments coincides with the location of the cell-type-specific enhancer.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Glucocorticoid-dependent oncogenic transformation by type 16 but not type 11 human papilloma virus DNA.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Oncogenes result in genomic alterations that activate a transcriptionally silent, dominantly selectable reporter gene (neo)

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Adenovirus transformation revertant resistant to retransformation by E1 but not by SV40-T and HPV16-E7 oncogenes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Transcriptional regulation. A closer look at E2F.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

The E6 oncoprotein encoded by human papillomavirus types 16 and 18 promotes the degradation of p53

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Viruses in human cancers

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

The E2F transcription factor is a cellular target for the RB protein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Suppression of tumor formation in vivo by expression of the JE gene in malignant cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Very high incidence of germ cell tumorigenesis (seminomagenesis) in human papillomavirus type 16 transgenic mice

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Properties of p53 mutations detected in primary and secondary cervical cancers suggest mechanisms of metastasis and involvement of environmental carcinogens

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Bovine papilloma virus-transformed cells contain multiple E2 proteins

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Structure-function analysis of the human papillomavirus type 16 E7 oncoprotein

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

High risk of squamous cell carcinoma of the cervix for women with HLA-DQw3

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Viral integration and fragile sites in human papillomavirus-immortalized human keratinocyte cell lines

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Enhanced degradation of p53 protein in HPV-6 and BPV-1 E6-immortalized human mammary epithelial cells.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Physical state and biological activity of human papillomavirus genomes in precancerous lesions of the female genital tract

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomavirus type 16 (HPV 16) gene expression and DNA replication in cervical neoplasia: Analysis by in situ hybridization

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Papillomavirus E7 protein binding to the retinoblastoma protein is not required for viral induction of warts

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

The human papilloma virus-16 E7 oncoprotein is able to bind to the retinoblastoma gene product

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Histologic, nuclear DNA, and human papillomavirus studies of cervical condylomas

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

HLA antigens and cervical carcinoma

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Efficiency of binding the retinoblastoma protein correlates with the transforming capacity of the E7 oncoproteins of the human papillomaviruses

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Identification of cellular proteins that can interact specifically with the T/ElA-binding region of the retinoblastoma gene product

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomavirus type 16 transformation of primary human embryonic fibroblasts requires expression of open reading frames E6 and E7

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomavirus 16 E6 expression disrupts the p53-mediated cellular response to DNA damage

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

A keratinocyte-specific transcription factor, KRF-1, interacts with AP-1 to activate expression of human papillomavirus type 18 in squamous epithelial cells

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Human papillomavirus E6 proteins bind p53 in vivo and abrogate p53-mediated repression of transcription

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Induction of chromosome abnormalities in mouse and human epidermal keratinocytes by the human papillomavirus type 16 E7 oncogene

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Two AP1 sites binding JunB are essential for human papillomavirus type 18 transcription in keratinocytes

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

A papillomavirus DNA from a cervical carcinoma and its prevalence in cancer biopsy samples from different geographic regions

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1007/978-3-642-78487-3_8

Identifiers

DOI

10.1007/978-3-642-78487-3_8

0 references

1 reference