Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. (Q40663995)

22 September 2017

title

Specific beta1 integrin site selectively regulates Akt/protein kinase B signaling via local activation of protein phosphatase 2A. (English)

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22 September 2017

7

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22 September 2017

1

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Edna Cukierman

2

object named as

Edna Cukierman

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22 September 2017

Katherine Clark

3

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22 September 2017

Kazue Matsumoto

4

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22 September 2017

Cornelia Hahn

5

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22 September 2017

Benoit Poulin

6

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22 September 2017

language of work or name

English

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publication date

11 March 2003

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Journal of Biological Chemistry

22 September 2017

number of pages

11

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based on heuristic

inferred from page(s)

published in

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22 September 2017

volume

278

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22 September 2017

issue

20

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22 September 2017

page(s)

18671-18681

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Integrins: bidirectional, allosteric signaling machines

22 September 2017

cites work

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https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrins in development: moving on, responding to, and sticking to the extracellular matrix

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Sensing the environment: a historical perspective on integrin signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Networks and crosstalk: integrin signalling spreads.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrin signaling: it's where the action is.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Get a ligand, get a life: integrins, signaling and cell survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrin signaling revisited

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Cell-substrate interactions and signaling through ILK

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Anchorage-dependent ERK signaling--mechanisms and consequences

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Biological aspects of signal transduction by cell adhesion receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Matrix survival signaling: from fibronectin via focal adhesion kinase to c-Jun NH(2)-terminal kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Extracellular matrix survival signals transduced by focal adhesion kinase suppress p53-mediated apoptosis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Two independent signaling pathways mediate the antiapoptotic action of macrophage-stimulating protein on epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

A signaling pathway from the alpha5beta1 and alpha(v)beta3 integrins that elevates bcl-2 transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

alpha5beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylinositol 3-kinase and protein kinase B-dependent pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

beta 1 integrin regulates fibroblast viability during collagen matrix contraction through a phosphatidylinositol 3-kinase/Akt/protein kinase B signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The alpha5beta1 integrin selectively enhances epidermal growth factor signaling to the phosphatidylinositol-3-kinase/Akt pathway in intestinal epithelial cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

p53 inhibits alpha 6 beta 4 integrin survival signaling by promoting the caspase 3-dependent cleavage of AKT/PKB

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Interleukin 3-dependent survival by the Akt protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Regulation of neuronal survival by the serine-threonine protein kinase Akt

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Dual role of phosphatidylinositol-3,4,5-trisphosphate in the activation of protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Phosphatidylinositol 3-kinase is required for integrin-stimulated AKT and Raf-1/mitogen-activated protein kinase pathway activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrin alpha 2 beta 1 promotes activation of protein phosphatase 2A and dephosphorylation of Akt and glycogen synthase kinase 3 beta.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Regulation of protein kinase cascades by protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Protein phosphatase 2A: the Trojan Horse of cellular signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Inactivation and dephosphorylation of protein kinase Balpha (PKBalpha) promoted by hyperosmotic stress

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Modulation of Akt kinase activity by binding to Hsp90

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

N-Ethylmaleimide inhibits platelet-derived growth factor BB-stimulated Akt phosphorylation via activation of protein phosphatase 2A.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrin transmembrane signaling and cytoskeletal control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Role of the cytoplasmic tyrosines of beta 1A integrins in transformation by v-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The cytoplasmic tyrosines of integrin subunit beta1 are involved in focal adhesion kinase activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Molecular analysis of the pac gene encoding a puromycin N-acetyl transferase from Streptomyces alboniger

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Identification of amino acid sequences in the integrin beta 1 cytoplasmic domain implicated in cytoskeletal association

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Modulation of beta1A integrin functions by tyrosine residues in the beta1 cytoplasmic domain

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Lack of beta 1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Assembly and function of integrin receptors is dependent on opposing alpha and beta cytoplasmic domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Breaking the integrin hinge. A defined structural constraint regulates integrin signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Interaction of plasma membrane fibronectin receptor with talin--a transmembrane linkage

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The Talin head domain binds to integrin beta subunit cytoplasmic tails and regulates integrin activation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The phosphotyrosine binding-like domain of talin activates integrins

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

An interaction between alpha-actinin and the beta 1 integrin subunit in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The cytoskeletal protein talin contains at least two distinct vinculin binding domains

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

A monoclonal antibody against an activation epitope on mouse integrin chain beta 1 blocks adhesion of lymphocytes to the endothelial integrin alpha 6 beta 1

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrin cytoplasmic domains mediate inside-out signal transduction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Inside-out integrin signalling

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Direct regulation of the Akt proto-oncogene product by phosphatidylinositol-3,4-bisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Phosphorylation of Ser-241 is essential for the activity of 3-phosphoinositide-dependent protein kinase-1: identification of five sites of phosphorylation in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Translocation of PDK-1 to the plasma membrane is important in allowing PDK-1 to activate protein kinase B

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Autophosphorylation of the focal adhesion kinase, pp125FAK, directs SH2-dependent binding of pp60src

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain regulates kinase activity: a role for Src family kinases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Integrin signaling and cell growth control

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Beta 1 integrin-dependent and -independent polymerization of fibronectin

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Effects of mutations in the cytoplasmic domain of integrin beta(1) to talin binding and cell spreading.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

A structural mechanism of integrin alpha(IIb)beta(3) "inside-out" activation as regulated by its cytoplasmic face

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Amino acid sequence of the human fibronectin receptor

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the β1 subunit

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M300879200

21 January 2018

Identifiers

DOI

10.1074/JBC.M300879200

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22 September 2017

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