Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector. (Q40551469)

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scientific article published on July 2004

Language	Label	Description	Also known as
English	Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector.	scientific article published on July 2004

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scholarly article

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29 December 2019

Enhanced efficacy of Escherichia coli nitroreductase/CB1954 prodrug activation gene therapy using an E1B-55K-deleted oncolytic adenovirus vector (English)

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29 December 2019

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Escherichia coli

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oncolytic virus

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based on heuristic

inferred from title

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based on heuristic

inferred from title

Lawrence S Young

7

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29 December 2019

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Chen MJ

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29 December 2019

Green NK

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29 December 2019

Reynolds GM

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29 December 2019

Flavell JR

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29 December 2019

Mautner V

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29 December 2019

Kerr DJ

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29 December 2019

Searle PF

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29 December 2019

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1 July 2004

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29 December 2019

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29 December 2019

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29 December 2019

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29 December 2019

1126-1136

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29 December 2019

The oncolytic virotherapy treatment platform for cancer: unique biological and biosafety points to consider

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Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection

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a controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

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Expression of the bacterial nitroreductase enzyme in mammalian cells renders them selectively sensitive to killing by the prodrug CB1954.

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The bioactivation of CB 1954 and its use as a prodrug in antibody-directed enzyme prodrug therapy (ADEPT).

1 reference

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21 January 2018

Sensitisation of human carcinoma cells to the prodrug CB1954 by adenovirus vector-mediated expression of E. coli nitroreductase.

1 reference

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21 January 2018

Virus directed enzyme prodrug therapy for ovarian and pancreatic cancer using retrovirally delivered E. coli nitroreductase and CB1954.

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21 January 2018

Combined adenovirus-mediated nitroreductase gene delivery and CB1954 treatment: a well-tolerated therapy for established solid tumors

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21 January 2018

DNA replication of first-generation adenovirus vectors in tumor cells

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Efficacy of a replication-competent adenovirus (ONYX-015) following intratumoral injection: intratumoral spread and distribution effects

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Genes in the service of therapeutic index: progress for virus-directed enzyme prodrug therapy

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21 January 2018

Evidence that replication of the antitumor adenovirus ONYX-015 is not controlled by the p53 and p14(ARF) tumor suppressor genes.

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21 January 2018

The differences in kinetics of rat and human DT diaphorase result in a differential sensitivity of derived cell lines to CB 1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide)

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21 January 2018

Immune enhancement of nitroreductase-induced cytotoxicity: studies using a bicistronic adenovirus vector

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Gene delivery from the E3 region of replicating human adenovirus: evaluation of the E3B region

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Characterization of 911: a new helper cell line for the titration and propagation of early region 1-deleted adenoviral vectors.

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Expression of Escherichia coli B nitroreductase in established human tumor xenografts in mice results in potent antitumoral and bystander effects upon systemic administration of the prodrug CB1954

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7 January 2021

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Virus-directed enzyme prodrug therapy: intratumoral administration of a replication-deficient adenovirus encoding nitroreductase to patients with resectable liver cancer

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An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy

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10.1038/SJ.GT.3302271

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Europe PubMed Central

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29 December 2019

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24 November 2022

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29 December 2019

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