A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. (Q40481673)

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English	A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.	scientific article

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6 January 2020

A novel CYR61-triggered 'CYR61-alphavbeta3 integrin loop' regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway (English)

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6 January 2020

Javier A Menendez

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6 January 2020

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Luciano Vellon

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6 January 2020

Inderjit Mehmi

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6 January 2020

Poh K Teng

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6 January 2020

David W Griggs

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6 January 2020

Ruth Lupu

6

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6 January 2020

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1 January 2005

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6 January 2020

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6 January 2020

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6 January 2020

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6 January 2020

761-779

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6 January 2020

Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells

1 reference

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7 January 2021

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CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth

1 reference

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7 January 2021

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The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts

1 reference

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7 January 2021

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Adhesion of human skin fibroblasts to Cyr61 is mediated through integrin alpha 6beta 1 and cell surface heparan sulfate proteoglycans

1 reference

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7 January 2021

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alpha(v) integrins regulate cell proliferation through integrin-linked kinase (ILK) in ovarian cancer cells

1 reference

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7 January 2021

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Low concentrations of paclitaxel induce cell type-dependent p53, p21 and G1/G2 arrest instead of mitotic arrest: molecular determinants of paclitaxel-induced cytotoxicity

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Integrin-mediated survival signals regulate the apoptotic function of Bax through its conformation and subcellular localization.

1 reference

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CYR61 stimulates human skin fibroblast migration through Integrin alpha vbeta 5 and enhances mitogenesis through integrin alpha vbeta 3, independent of its carboxyl-terminal domain

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7 January 2021

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Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha(IIb)beta(3)

1 reference

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7 January 2021

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Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin alphavbeta3.

1 reference

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7 January 2021

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The CCN family of angiogenic regulators: the integrin connection

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7 January 2021

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Pro-angiogenic activities of CYR61 (CCN1) mediated through integrins alphavbeta3 and alpha6beta1 in human umbilical vein endothelial cells.

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7 January 2021

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Cyr61 expression confers resistance to apoptosis in breast cancer MCF-7 cells by a mechanism of NF-kappaB-dependent XIAP up-regulation

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7 January 2021

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MEK inhibition enhances paclitaxel-induced tumor apoptosis

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7 January 2021

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Expression of alphav integrins and vitronectin receptor identity in breast cancer cells

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Cell adhesion and the integrin-linked kinase regulate the LEF-1 and beta-catenin signaling pathways

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Taxol binds to polymerized tubulin in vitro

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CCN proteins: multifunctional signalling regulators

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7 January 2021

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A structural approach to the role of CCN (CYR61/CTGF/NOV) proteins in tumourigenesis

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Overexpression of the integrin-linked kinase promotes anchorage-independent cell cycle progression

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ERK1 associates with alpha(v)beta 3 integrin and regulates cell spreading on vitronectin

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Activated Ras prevents downregulation of Bcl-X(L) triggered by detachment from the extracellular matrix. A mechanism of Ras-induced resistance to anoikis in intestinal epithelial cells

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Cyr61, a member of the CCN family, is required for MCF-7 cell proliferation: regulation by 17beta-estradiol and overexpression in human breast cancer

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Promotion of microtubule assembly in vitro by taxol

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The role of ERK 1/2 and p38 MAP-kinase pathways in taxol-induced apoptosis in human ovarian carcinoma cells

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Cyr61 promotes breast tumorigenesis and cancer progression

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Breast cancer. Cyr61 is overexpressed, estrogen-inducible, and associated with more advanced disease

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10.1038/SJ.ONC.1208238

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Europe PubMed Central

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6 January 2020

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6 January 2020

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