Exploring the specificity of the PI3K family inhibitor LY294002. (Q40170788)

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25 December 2019

title

Exploring the specificity of the PI3K family inhibitor LY294002 (English)

1 reference

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25 December 2019

2

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25 December 2019

author name string

Severine I Gharbi

1

1 reference

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25 December 2019

Stephen J Shuttleworth

3

1 reference

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25 December 2019

Tim Hancox

4

1 reference

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25 December 2019

Nahid Saghir

5

1 reference

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25 December 2019

John F Timms

6

1 reference

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25 December 2019

Michael D Waterfield

7

1 reference

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25 December 2019

language of work or name

English

0 references

publication date

1 May 2007

1 reference

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25 December 2019

1 reference

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25 December 2019

volume

404

1 reference

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25 December 2019

issue

1

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25 December 2019

page(s)

15-21

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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism

25 December 2019

cites work

1 reference

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p97: The cell's molecular purgatory?

22 September 2017

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A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma

22 September 2017

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A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling

22 September 2017

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Critical role for the p110alpha phosphoinositide-3-OH kinase in growth and metabolic regulation

22 September 2017

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Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis

22 September 2017

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Exploiting the PI3K/AKT pathway for cancer drug discovery

22 September 2017

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The PI3K inhibitor LY294002 blocks drug export from resistant colon carcinoma cells overexpressing MRP1.

22 September 2017

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The phosphoinositide 3-kinase signalling pathway as a therapeutic target in squamous cell carcinoma of the head and neck.

22 September 2017

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LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway

22 September 2017

1 reference

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Roscovitine targets, protein kinases and pyridoxal kinase

22 September 2017

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Phosphoinositide 3-kinases as drug targets in cancer

22 September 2017

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LY294002 inhibits LPS-induced NO production through a inhibition of NF-kappaB activation: independent mechanism of phosphatidylinositol 3-kinase

22 September 2017

1 reference

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Role of phosphoinositide 3-kinase regulatory isoforms in development and actin rearrangement

22 September 2017

1 reference

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Pim-1 ligand-bound structures reveal the mechanism of serine/threonine kinase inhibition by LY294002.

22 September 2017

1 reference

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Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic

22 September 2017

1 reference

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Bromodomain analysis of Brd2-dependent transcriptional activation of cyclin A.

22 September 2017

1 reference

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Bromodomain protein Brd4 binds to GTPase-activating SPA-1, modulating its activity and subcellular localization

22 September 2017

1 reference

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Genomic organization, tissue distribution and deletion mutation of human pyridoxine 5'-phosphate oxidase

22 September 2017

1 reference

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High frequency of mutations of the PIK3CA gene in human cancers

22 September 2017

1 reference

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An efficient proteomics method to identify the cellular targets of protein kinase inhibitors.

22 September 2017

1 reference

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Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains

22 September 2017

1 reference

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The double bromodomain protein Brd4 binds to acetylated chromatin during interphase and mitosis

22 September 2017

1 reference

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Assembly of Cell Regulatory Systems Through Protein Interaction Domains

22 September 2017

1 reference

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GSK-3: tricks of the trade for a multi-tasking kinase

22 September 2017

1 reference

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Impaired B and T cell antigen receptor signaling in p110delta PI 3-kinase mutant mice

22 September 2017

1 reference

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Evaluation of two-dimensional differential gel electrophoresis for proteomic expression analysis of a model breast cancer cell system

22 September 2017

1 reference

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Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network

22 September 2017

1 reference

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Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine

22 September 2017

1 reference

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

22 September 2017

1 reference

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A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways

22 September 2017

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Signaling by distinct classes of phosphoinositide 3-kinases

22 September 2017

1 reference

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The role of phosphoinositide 3-kinase lipid products in cell function

22 September 2017

1 reference

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Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase

22 September 2017

1 reference

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Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002.

22 September 2017

1 reference

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Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

22 September 2017

1 reference

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A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002)

22 September 2017

1 reference

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Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells.

22 September 2017

1 reference

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Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.

22 September 2017

1 reference

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25 September 2017

Phosphoinositide kinases

1 reference

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Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses.

25 September 2017

1 reference

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Activating transcription factor 3 and early growth response 1 are the novel targets of LY294002 in a phosphatidylinositol 3-kinase-independent pathway

15 June 2018

1 reference

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Key role of the p110delta isoform of PI3K in B-cell antigen and IL-4 receptor signaling: comparative analysis of genetic and pharmacologic interference with p110delta function in B cells

20 August 2018

1 reference

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LY-294002 [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects calcium signaling in airway smooth muscle cells independently of phosphoinositide 3-kinase inhibition

20 August 2018

1 reference

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PDE2 inhibition by the PI3 kinase inhibitor LY294002 and analogues

20 August 2018

1 reference

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LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism

20 August 2018

1 reference

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Intracellular Targets of Paullones. Identification following affinity purification on immobilized inhibitor

20 August 2018

1 reference

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Protein kinase CK2 in mammary gland tumorigenesis

20 August 2018

1 reference

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Characterization of a soluble adrenal phosphatidylinositol 4-kinase reveals wortmannin sensitivity of type III phosphatidylinositol kinases

20 August 2018

1 reference

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Structural insights into phosphoinositide 3-kinase catalysis and signalling

20 August 2018

1 reference

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Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils

4 November 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17302559

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1042/BJ20061489

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:17302559%20AND%20SRC:MED&resulttype=core&format=json

25 December 2019

1 reference

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25 December 2019

PubMed publication ID

17302559

1 reference