SOX9 determines RUNX2 transactivity by directing intracellular degradation (Q39686293)

14 September 2017

title

SOX9 determines RUNX2 transactivity by directing intracellular degradation (English)

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14 September 2017

2

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14 September 2017

Aixin Cheng

1

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14 September 2017

publication date

30 June 2010

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Journal of Bone and Mineral Research

14 September 2017

published in

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14 September 2017

volume

25

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14 September 2017

issue

12

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14 September 2017

page(s)

2680-2689

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https://api.crossref.org/works/10.1002%2FJBMR.174

14 September 2017

1 reference

Aetiology of the skeletal dysmorphology syndrome campomelic dysplasia: expression of the Sox9 gene during chondrogenesis in mouse embryos.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

SOX9 directly regulates the type-II collagen gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

SOX9 is a potent activator of the chondrocyte-specific enhancer of the pro alpha1(II) collagen gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

SOX9 binds DNA, activates transcription, and coexpresses with type II collagen during chondrogenesis in the mouse

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Sox9 is required for cartilage formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

SOX9 enhances aggrecan gene promoter/enhancer activity and is up-regulated by retinoic acid in a cartilage-derived cell line, TC6.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Genetic study of SOX9 in a case of campomelic dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

CHIP promotes Runx2 degradation and negatively regulates osteoblast differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

A Runx2 threshold for the cleidocranial dysplasia phenotype

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

A novel RUNX2 mutation in cleidocranial dysplasia patients

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Functional analysis of RUNX2 mutations in cleidocranial dysplasia: novel insights into genotype–phenotype correlations

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

A RUNX2/PEBP2alphaA/CBFA1 mutation in cleidocranial dysplasia revealing the link between the gene and Smad

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

A RUNX2/PEBP2alpha A/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Cleidocranial dysplasia with decreased bone density and biochemical findings of hypophosphatasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Smad6 interacts with Runx2 and mediates Smad ubiquitin regulatory factor 1-induced Runx2 degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Cyclin D1-cdk4 induce runx2 ubiquitination and degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Phosphorylation, acetylation and ubiquitination: the molecular basis of RUNX regulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

The transcription factor Sox9 is degraded by the ubiquitin-proteasome system and stabilized by a mutation in a ubiquitin-target site.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Prostaglandin D2 induces nuclear import of the sex-determining factor SOX9 via its cAMP-PKA phosphorylation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Bone morphogenetic protein-2 induces chromatin remodeling and modification at the proximal promoter of Sox9 gene

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Histone deacetylase inhibitors induce growth arrest, apoptosis, and differentiation in clear cell sarcoma models

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Overlapping expression of Runx1(Cbfa2) and Runx2(Cbfa1) transcription factors supports cooperative induction of skeletal development

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Dominance of SOX9 function over RUNX2 during skeletogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Cbfa1 is a positive regulatory factor in chondrocyte maturation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

SOX9 is an intestine crypt transcription factor, is regulated by the Wnt pathway, and represses the CDX2 and MUC2 genes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Runx3 negatively regulates Osterix expression in dental pulp cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Functional gene screening system identified TRPV4 as a regulator of chondrogenic differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

RhoA/ROCK signaling regulates Sox9 expression and actin organization during chondrogenesis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Sox9-dependent transcriptional regulation of the proprotein convertase furin

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Inhibition of osteoblast-specific transcription factor Cbfa1 by the cAMP pathway in osteoblastic cells. Ubiquitin/proteasome-dependent regulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Proteasome inhibitors: valuable new tools for cell biologists

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Control of spontaneous and damage-induced mutagenesis by SUMO and ubiquitin conjugation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

SUMOsp: a web server for sumoylation site prediction

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

beta-catenin is a target for the ubiquitin-proteasome pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Osteo-chondroprogenitor cells are derived from Sox9 expressing precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Serine phosphorylation of RUNX2 with novel potential functions as negative regulatory mechanisms

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

A hedgehog-responsive region in the Drosophila wing disc is defined by debra-mediated ubiquitination and lysosomal degradation of Ci.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Sox9 inhibits Wnt signaling by promoting beta-catenin phosphorylation in the nucleus

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Interactions between Sox9 and beta-catenin control chondrocyte differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Lysosome-dependent degradation of Notch3.

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Sox9 directly promotes Bapx1 gene expression to repress Runx2 in chondrocytes

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

Loss of DNA-dependent dimerization of the transcription factor SOX9 as a cause for campomelic dysplasia

21 January 2018

1 reference

https://api.crossref.org/works/10.1002%2FJBMR.174

21 January 2018

Identifiers

DOI

10.1002/JBMR.174

1 reference

14 September 2017

1 reference