p53 and its mutants on the slippery road from stemness to carcinogenesis (Q38740922)

6 September 2017

title

p53 and its mutants on the slippery road from stemness to carcinogenesis (English)

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6 September 2017

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2

Varda Rotter

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6 September 2017

Alina Molchadsky

1

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6 September 2017

language of work or name

English

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publication date

15 March 2017

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6 September 2017

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6 September 2017

volume

38

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6 September 2017

issue

4

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6 September 2017

page(s)

347-358

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Cellular homeostasis and repair in the mammalian liver

6 September 2017

cites work

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The developmental potential of iPSCs is greatly influenced by reprogramming factor selection

21 January 2018

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Cell type of origin influences the molecular and functional properties of mouse induced pluripotent stem cells

21 January 2018

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Variation in the safety of induced pluripotent stem cell lines

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Copy number variation and selection during reprogramming to pluripotency

21 January 2018

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Cancer: pathological nuclear reprogramming?

21 January 2018

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Cellular reprogramming and cancer development

21 January 2018

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Mechanisms that regulate stem cell aging and life span

21 January 2018

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21 January 2018

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The elusive nature and function of mesenchymal stem cells

21 January 2018

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Effects of donor age, gender, and in vitro cellular aging on the phenotypic, functional, and molecular characteristics of mouse bone marrow-derived mesenchymal stem cells.

21 January 2018

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Concise review: Genomic instability in human stem cells: current status and future challenges.

21 January 2018

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Stem cell concepts renew cancer research

21 January 2018

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Cancer drug resistance: an evolving paradigm

21 January 2018

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Complexity of cancer stem cells

21 January 2018

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Cancer stem cells--old concepts, new insights.

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Cancer stem cells: the promise and the potential.

21 January 2018

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Cancer etiology. Variation in cancer risk among tissues can be explained by the number of stem cell divisions

21 January 2018

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Cancer studies clash over mechanisms of malignancy.

21 January 2018

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Loss of TGF-β adaptor β2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma

21 January 2018

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CD133 as a biomarker for putative cancer stem cells in solid tumours: limitations, problems and challenges

21 January 2018

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Cancer stem cells: perspectives for therapeutic targeting

21 January 2018

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ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcome

21 January 2018

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Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties

21 January 2018

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The role of BMI1 as a biomarker of cancer stem cells in head and neck cancer: a review

21 January 2018

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Mdm2 promotes the rapid degradation of p53

21 January 2018

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New insights into p53 activation

21 January 2018

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Ferroptosis as a p53-mediated activity during tumour suppression

21 January 2018

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Senescence and aging: the critical roles of p53.

21 January 2018

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DRAM, a p53-induced modulator of autophagy, is critical for apoptosis

21 January 2018

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Apoptosis - the p53 network

21 January 2018

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Structural biology of the tumor suppressor p53.

21 January 2018

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Decision making by p53: life, death and cancer

21 January 2018

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Blinded by the Light: The Growing Complexity of p53

21 January 2018

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The relevance of protein-protein interactions for p53 function: the CPE contribution.

21 January 2018

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Involvement of stromal p53 in tumor-stroma interactions.

21 January 2018

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Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation.

21 January 2018

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Non-cell-autonomous tumor suppression by p53.

21 January 2018

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Metabolic regulation by p53.

21 January 2018

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21 January 2018

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Caught in the cross fire: p53 in inflammation.

21 January 2018

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p53 mutant mice that display early ageing-associated phenotypes

21 January 2018

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The p53 family: guardians of maternal reproduction

21 January 2018

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p53 is balancing development, differentiation and de-differentiation to assure cancer prevention.

21 January 2018

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p53 orchestrates between normal differentiation and cancer.

21 January 2018

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Tumor suppressors: enhancers or suppressors of regeneration?

21 January 2018

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Mutations in the p53 Tumor Suppressor Gene: Important Milestones at the Various Steps of Tumorigenesis

21 January 2018

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The IARC TP53 database: new online mutation analysis and recommendations to users

21 January 2018

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Mutant p53: one name, many proteins

21 January 2018

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TP53 in hematological cancer: low incidence of mutations with significant clinical relevance

21 January 2018

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Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary

21 January 2018

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

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Effects of TP53 mutational status on gene expression patterns across 10 human cancer types.

21 January 2018

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Mutant p53 in cancer: new functions and therapeutic opportunities

21 January 2018

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Gain of function mutations in p53.

21 January 2018

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21 January 2018

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Gain-of-function mutant p53 but not p53 deletion promotes head and neck cancer progression in response to oncogenic K-ras.

21 January 2018

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YAP enhances the pro-proliferative transcriptional activity of mutant p53 proteins

21 January 2018

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A mutant p53 protein is required for maintenance of the transformed phenotype in cells transformed with p53 plus ras cDNAs

21 January 2018

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Modulation of the vitamin D3 response by cancer-associated mutant p53

21 January 2018

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Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer.

21 January 2018

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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

21 January 2018

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p53 and its mutants in tumor cell migration and invasion

21 January 2018

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The paradigm of mutant p53-expressing cancer stem cells and drug resistance

21 January 2018

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Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database

21 January 2018

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Mechanisms of mutant p53 stabilization in cancer

21 January 2018

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The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss

21 January 2018

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Tumor-specific signaling to p53 is mimicked by Mdm2 inactivation in zebrafish: insights from mdm2 and mdm4 mutant zebrafish

21 January 2018

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Improving survival by exploiting tumour dependence on stabilized mutant p53 for treatment

21 January 2018

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Mechanisms of disease: Oncogene addiction--a rationale for molecular targeting in cancer therapy

21 January 2018

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Prion-like aggregation of mutant p53 in cancer

21 January 2018

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A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas

21 January 2018

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p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells

21 January 2018

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P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells.

21 January 2018

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Regulation of ES cell differentiation by functional and conformational modulation of p53.

21 January 2018

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Nuclear accumulation and activation of p53 in embryonic stem cells after DNA damage

21 January 2018

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Regulation of p53 in embryonic stem cells

21 January 2018

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ES cells do not activate p53-dependent stress responses and undergo p53-independent apoptosis in response to DNA damage

21 January 2018

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SIRT1 regulates apoptosis and Nanog expression in mouse embryonic stem cells by controlling p53 subcellular localization

21 January 2018

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p53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression

21 January 2018

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Activation of DNA damage response signaling in mouse embryonic stem cells

21 January 2018

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G1 checkpoint is compromised in mouse ESCs due to functional uncoupling of p53-p21Waf1 signaling

21 January 2018

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Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling

21 January 2018

1 reference

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Distinct regulatory mechanisms and functions for p53-activated and p53-repressed DNA damage response genes in embryonic stem cells

21 January 2018

1 reference

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p53 is required for brown adipogenic differentiation and has a protective role against diet-induced obesity

21 January 2018

1 reference

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p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner

21 January 2018

1 reference

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A genomewide study identifies the Wnt signaling pathway as a major target of p53 in murine embryonic stem cells

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis

21 January 2018

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The evolution of thymic lymphomas in p53 knockout mice

21 January 2018

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Rescue of embryonic stem cells from cellular transformation by proteomic stabilization of mutant p53 and conversion into WT conformation.

21 January 2018

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Interaction of p53 with the CCT complex promotes protein folding and wild-type p53 activity

21 January 2018

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Back to basics: Refined nuclear reprogramming techniques yield higher-quality stem cells

21 January 2018

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Immortalization eliminates a roadblock during cellular reprogramming into iPS cells

21 January 2018

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Linking the p53 tumour suppressor pathway to somatic cell reprogramming

21 January 2018

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Suppression of induced pluripotent stem cell generation by the p53-p21 pathway

21 January 2018

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A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

21 January 2018

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The Ink4/Arf locus is a barrier for iPS cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Direct cell reprogramming is a stochastic process amenable to acceleration

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

miR-34 miRNAs provide a barrier for somatic cell reprogramming

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Multiple roles of p53-related pathways in somatic cell reprogramming and stem cell differentiation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

p53 counteracts reprogramming by inhibiting mesenchymal-to-epithelial transition

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Mutant p53 facilitates somatic cell reprogramming and augments the malignant potential of reprogrammed cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Modeling familial cancer with induced pluripotent stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Osteosarcoma development and stem cell differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

High-frequency developmental abnormalities in p53-deficient mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

The non-apoptotic role of p53 in neuronal biology: enlightening the dark side of the moon

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

p53 regulates the self-renewal and differentiation of neural precursors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

A GLI1-p53 inhibitory loop controls neural stem cell and tumour cell numbers

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Conversion of fibroblasts to neural cells by p53 depletion

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Cell cycle and p53 gate the direct conversion of human fibroblasts to dopaminergic neurons.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Modeling sarcomagenesis using multipotent mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

p53 regulates the proliferation, differentiation and spontaneous transformation of mesenchymal stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

p53 loss increases the osteogenic differentiation of bone marrow stromal cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

p53 and MDM2 are involved in the regulation of osteocalcin gene expression.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Transplantation of adipose tissue and stem cells: role in metabolism and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

p53 regulates mesenchymal stem cell-mediated tumor suppression in a tumor microenvironment through immune modulation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Loss of p53 induces tumorigenesis in p21-deficient mesenchymal stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Gain-of-function of mutant p53: mutant p53 enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Mutant p53 gain-of-function induces epithelial-mesenchymal transition through modulation of the miR-130b-ZEB1 axis.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Dedifferentiation of neurons and astrocytes by oncogenes can induce gliomas in mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Differentiation-induced skin cancer suppression by FOS, p53, and TACE/ADAM17.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Mutant p53 Promotes Epithelial Ovarian Cancer by Regulating Tumor Differentiation, Metastasis, and Responsiveness to Steroid Hormones.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Frequent clones of p53-mutated keratinocytes in normal human skin

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Transcriptional repression of cancer stem cell marker CD133 by tumor suppressor p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Ovarian surface epithelium at the junction area contains a cancer-prone stem cell niche

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Expression of mutant p53 proteins implicates a lineage relationship between neural stem cells and malignant astrocytic glioma in a murine model

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Inhibition of oxidative metabolism leads to p53 genetic inactivation and transformation in neural stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Brain cancer stem-like cell genesis from p53-deficient mouse astrocytes by oncogenic Ras.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Nanog-induced dedifferentiation of p53-deficient mouse astrocytes into brain cancer stem-like cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Loss of interactions between p53 and survivin gene in mesenchymal stem cells after spontaneous transformation in vitro.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Mutant p53 gain of function can be at the root of dedifferentiation of human osteosarcoma MG63 cells into 3AB-OS cancer stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

The p53 isoform Δ133p53β promotes cancer stem cell potential

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound.

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Gain of function of mutant p53 by coaggregation with multiple tumor suppressors

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation

21 January 2018

1 reference

https://api.crossref.org/works/10.1093%2FCARCIN%2FBGW092

21 January 2018

Identifiers

DOI

10.1093/CARCIN/BGW092

1 reference

6 September 2017

1 reference