The calcium-sensing receptor in bone metabolism: from bench to bedside and back (Q38534776)

3 September 2017

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title

The calcium-sensing receptor in bone metabolism: from bench to bedside and back (English)

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3 September 2017

5

M L Brandi

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3 September 2017

L Cianferotti

1

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3 September 2017

A R Gomes

series ordinal

2

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3 September 2017

S Fabbri

series ordinal

3

1 reference

3 September 2017

A Tanini

series ordinal

4

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3 September 2017

language of work or name

English

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publication date

23 June 2015

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Osteoporosis International

3 September 2017

published in

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3 September 2017

volume

26

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3 September 2017

issue

8

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3 September 2017

page(s)

2055-2071

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Cloning and characterization of an extracellular Ca(2+)-sensing receptor from bovine parathyroid

3 September 2017

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A low calcium environment enhances AP-1 transcription factor-mediated gene expression in the development of osteoblastic MC3T3-E1 cells

21 January 2018

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Calcium-sensing receptor-mediated activation of phospholipase C-gamma1 is downstream of phospholipase C-beta and protein kinase C in MC3T3-E1 osteoblasts

21 January 2018

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Mitogenic action of calcium-sensing receptor on rat calvarial osteoblasts

21 January 2018

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An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts.

21 January 2018

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Elevation of extracellular Ca2+ induces store-operated calcium entry via calcium-sensing receptors: a pathway contributes to the proliferation of osteoblasts

21 January 2018

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The roles of calcium-sensing receptor and calcium channel in osteogenic differentiation of undifferentiated periodontal ligament cells

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Low calcium environment effects osteoprotegerin ligand/osteoclast differentiation factor

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The calcium sensing receptor is directly involved in both osteoclast differentiation and apoptosis

21 January 2018

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Implication of the calcium sensing receptor and the Phosphoinositide 3-kinase/Akt pathway in the extracellular calcium-mediated migration of RAW 264.7 osteoclast precursor cells

21 January 2018

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Elevated extracellular calcium concentrations induce type X collagen synthesis in chondrocyte cultures

21 January 2018

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Alterations in the sensing and transport of phosphate and calcium by differentiating chondrocytes

21 January 2018

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Extracellular Ca(2+)-sensing receptors modulate matrix production and mineralization in chondrogenic RCJ3.1C5.18 cells

21 January 2018

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A mouse model of human familial hypocalciuric hypercalcemia and neonatal severe hyperparathyroidism

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The calcium-sensing receptor is required for normal calcium homeostasis independent of parathyroid hormone

21 January 2018

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The abnormal phenotypes of cartilage and bone in calcium-sensing receptor deficient mice are dependent on the actions of calcium, phosphorus, and PTH.

21 January 2018

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The calcium sensing receptor and its alternatively spliced form in keratinocyte differentiation

21 January 2018

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Expression and functional assessment of an alternatively spliced extracellular Ca2+-sensing receptor in growth plate chondrocytes

21 January 2018

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Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification

21 January 2018

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Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.

21 January 2018

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Assessing constitutive activity of extracellular calcium-sensing receptors in vitro and in bone

21 January 2018

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The extracellular calcium-sensing receptor (CaSR) is a critical modulator of skeletal development

21 January 2018

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21 January 2018

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Osteoblast extracellular Ca2+ -sensing receptor regulates bone development, mineralization, and turnover

21 January 2018

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Alterations in phosphorus, calcium and PTHrP contribute to defects in dental and dental alveolar bone formation in calcium-sensing receptor-deficient mice

21 January 2018

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The calcium-sensing receptor mediates bone turnover induced by dietary calcium and parathyroid hormone in neonates

21 January 2018

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The calcium-sensing receptor complements parathyroid hormone-induced bone turnover in discrete skeletal compartments in mice

21 January 2018

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Calcium signalling and calcium transport in bone disease

21 January 2018

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A ryanodine receptor-like molecule expressed in the osteoclast plasma membrane functions in extracellular Ca2+ sensing.

21 January 2018

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Calcyclin mediates serum response element (SRE) activation by an osteoblastic extracellular cation-sensing mechanism.

21 January 2018

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A novel cation-sensing mechanism in osteoblasts is a molecular target for strontium

21 January 2018

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Identification of a novel extracellular cation-sensing G-protein-coupled receptor

21 January 2018

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The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function

21 January 2018

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GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome

21 January 2018

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Osteocalcin regulates murine and human fertility through a pancreas-bone-testis axis

21 January 2018

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No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions.

21 January 2018

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Phosphate-dependent stimulation of MGP and OPN expression in osteoblasts via the ERK1/2 pathway is modulated by calcium

21 January 2018

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Skeletal consequences of familial hypocalciuric hypercalcaemia vs. primary hyperparathyroidism

21 January 2018

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PTH(1-34) replacement therapy in a child with hypoparathyroidism caused by a sporadic calcium receptor mutation

21 January 2018

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Increased trabecular volumetric bone mass density in Familial Hypocalciuric Hypercalcemia (FHH) type 1: a cross-sectional study.

21 January 2018

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21 January 2018

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A review on strontium ranelate long-term antifracture efficacy in the treatment of postmenopausal osteoporosis

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Ronacaleret, a calcium-sensing receptor antagonist, has no significant effect on radial fracture healing time: results of a randomized, double-blinded, placebo-controlled Phase II clinical trial

21 January 2018

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Ronacaleret, a calcium-sensing receptor antagonist, increases trabecular but not cortical bone in postmenopausal women.

21 January 2018

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Characterization of the effect of chronic administration of a calcium-sensing receptor antagonist, ronacaleret, on renal calcium excretion and serum calcium in postmenopausal women.

21 January 2018

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Preserved three-dimensional cancellous bone structure in mild primary hyperparathyroidism

21 January 2018

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JTT-305, an orally active calcium-sensing receptor antagonist, stimulates transient parathyroid hormone release and bone formation in ovariectomized rats.

21 January 2018

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A phase 2, randomized, placebo-controlled, dose-ranging study of the calcium-sensing receptor antagonist MK-5442 in the treatment of postmenopausal women with osteoporosis

21 January 2018

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ATF936, a novel oral calcilytic, increases bone mineral density in rats and transiently releases parathyroid hormone in humans.

21 January 2018

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AXT914 a novel, orally-active parathyroid hormone-releasing drug in two early studies of healthy volunteers and postmenopausal women

21 January 2018

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Calcilytics: antagonists of the calcium-sensing receptor for the treatment of osteoporosis

21 January 2018

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Identification and characterization of D410E, a novel mutation in the loop 3 domain of CASR, in autosomal dominant hypocalcemia and a therapeutic approach using a novel calcilytic, AXT914.

21 January 2018

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Calcimimetics with potent and selective activity on the parathyroid calcium receptor

21 January 2018

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Clinical utility of calcimimetics targeting the extracellular calcium-sensing receptor (CaSR).

21 January 2018

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Cinacalcet hydrochloride maintains long-term normocalcemia in patients with primary hyperparathyroidism

21 January 2018

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Cinacalcet treatment of primary hyperparathyroidism: biochemical and bone densitometric outcomes in a five-year study

21 January 2018

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Efficacy and safety of currently marketed anti-osteoporosis medications.

21 January 2018

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In vitro effects of S12911-2 on osteoclast function and bone marrow macrophage differentiation

21 January 2018

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Strontium ranelate improves bone resistance by increasing bone mass and improving architecture in intact female rats

21 January 2018

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The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis

21 January 2018

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Strontium ranelate reduces the risk of nonvertebral fractures in postmenopausal women with osteoporosis: Treatment of Peripheral Osteoporosis (TROPOS) study.

21 January 2018

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Strontium signaling: molecular mechanisms and therapeutic implications in osteoporosis

21 January 2018

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Strontium ranelate decreases receptor activator of nuclear factor-ΚB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor

21 January 2018

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The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways

21 January 2018

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Osteoblasts play key roles in the mechanisms of action of strontium ranelate

21 January 2018

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The effects of ronacaleret, a calcium-sensing receptor antagonist, on bone mineral density and biochemical markers of bone turnover in postmenopausal women with low bone mineral density

21 January 2018

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

High extracellular calcium concentrations directly stimulate osteoclast apoptosis

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Extracellular calcium causes the release of calcium from intracellular stores in chick osteocytes

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12 December 2020

Calcimimetics for secondary hyperparathyroidism in chronic kidney disease patients

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12 December 2020

Scanning electrochemical microscopy at the surface of bone-resorbing osteoclasts: evidence for steady-state disposal and intracellular functional compartmentalization of calcium

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12 December 2020

A calcium-induced signaling cascade leading to osteogenic differentiation of human bone marrow-derived mesenchymal stromal cells

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Effects of Ca2+ sensing receptor activation in the growth plate

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Rickets in cation-sensing receptor-deficient mice: an unexpected skeletal phenotype

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Novel activating mutations of the calcium-sensing receptor: the calcilytic NPS-2143 mitigates excessive signal transduction of mutant receptors

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

High extracellular calcium inhibits osteoclast-like cell formation by directly acting on the calcium-sensing receptor existing in osteoclast precursor cells

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Expression of extracellular calcium-sensing receptor in human osteoblastic MG-63 cell line

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Bone mineral density in patients with familial hypocalciuric hypercalcaemia (FHH)

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Calcium-sensing receptors in bone cells

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12 December 2020

Extracellular calcium (Ca2+(o))-sensing receptor in a murine bone marrow-derived stromal cell line (ST2): potential mediator of the actions of Ca2+(o) on the function of ST2 cells

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12 December 2020

Calcilytic compounds: potent and selective Ca2+ receptor antagonists that stimulate secretion of parathyroid hormone.

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12 December 2020

Bone mineral density changes following discontinuation of ronacaleret treatment: off-treatment extension of a randomized, dose-finding phase II trial

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12 December 2020

Bone histomorphometry before and after long-term treatment with cinacalcet in dialysis patients with secondary hyperparathyroidism

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12 December 2020

Extracellular calcium and platelet-derived growth factor promote receptor-mediated chemotaxis in osteoblasts through different signaling pathways

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https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Expression and signal transduction of calcium-sensing receptors in cartilage and bone

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12 December 2020

The calcium-sensing receptor and 25-hydroxyvitamin D-1alpha-hydroxylase interact to modulate skeletal growth and bone turnover

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12 December 2020

Calcium-sensing receptor in mature osteoclasts, which are bone resorbing cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Strontium ranelate: a dual mode of action rebalancing bone turnover in favour of bone formation

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Effect of phosphate, calcium and magnesium on bone resorption and hormonal responses in tissue culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Receptor-operated osteoclast calcium sensing

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Extracellular calcium-sensing-receptor (CaR)-mediated opening of an outward K(+) channel in murine MC3T3-E1 osteoblastic cells: evidence for expression of a functional CaR.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Chondrogenic potential of chick embryonic calvaria: I. Low calcium permits cartilage differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

Bone mineral density and skeletal fractures in familial benign hypercalcemia (hypocalciuric hypercalcemia)

1 reference

https://pubmed.ncbi.nlm.nih.gov/26100412

12 December 2020

10.1007/S00198-015-3203-1

Identifiers

DOI

1 reference

Dimensions Publication ID

3 September 2017

1021150132

0 references

1 reference