Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control (Q38325277)

2 September 2017

title

Tumor-associated WT1 missense mutants indicate that transcriptional activation by WT1 is critical for growth control (English)

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2 September 2017

English MA

1

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2 September 2017

Licht JD

series ordinal

2

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2 September 2017

language of work or name

English

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publication date

1 May 1999

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Journal of Biological Chemistry

2 September 2017

published in

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2 September 2017

volume

274

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2 September 2017

issue

19

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2 September 2017

page(s)

13258-13263

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New developments in the pathology of Wilms tumor

2 September 2017

cites work

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WT-1 is required for early kidney development

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A second transcriptionally active DNA-binding site for the Wilms tumor gene product, WT1

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Increased expression of the insulin-like growth factor I receptor gene, IGF1R, in Wilms tumor is correlated with modulation of IGF1R promoter activity by the WT1 Wilms tumor gene product

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The WT1 protein is a negative regulator of the normal bcl-2 allele in t(14;18) lymphomas

21 January 2018

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WT1-mediated transcriptional activation is inhibited by dominant negative mutant proteins.

21 January 2018

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Truncated WT1 mutants alter the subnuclear localization of the wild-type protein

21 January 2018

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21 January 2018

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21 January 2018

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Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

21 January 2018

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WT1 interacts with the splicing factor U2AF65 in an isoform-dependent manner and can be incorporated into spliceosomes

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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A novel repressor, par-4, modulates transcription and growth suppression functions of the Wilms' tumor suppressor WT1

21 January 2018

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Ciao 1 is a novel WD40 protein that interacts with the tumor suppressor protein WT1

21 January 2018

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21 January 2018

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21 January 2018

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Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript

21 January 2018

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Repression of the insulin-like growth factor II gene by the Wilms tumor suppressor WT1

21 January 2018

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Autoregulation of the human WT1 gene promoter

21 January 2018

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Constitutional mutations in the WT1 gene in patients with Denys-Drash syndrome

21 January 2018

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Evidence that WT1 mutations in Denys — Drash syndrome patients may act in a dominant-negative fashion

21 January 2018

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A novel insertional mutation at the third zinc finger coding region of the WT1 gene in Denys-Drash syndrome

21 January 2018

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Inactivation of WT1 in nephrogenic rests, genetic precursors to Wilms' tumour

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.274.19.13258

21 January 2018

Identifiers

DOI

10.1074/JBC.274.19.13258

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2 September 2017

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