Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease (Q38112215)

29 August 2017

title

Network modeling to identify new mechanisms and therapeutic targets for Parkinson's disease (English)

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29 August 2017

Linda MacArthur

1

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29 August 2017

Habtom Ressom

series ordinal

2

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29 August 2017

Salim Shah

series ordinal

3

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29 August 2017

Howard J Federoff

series ordinal

4

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29 August 2017

publication date

1 June 2013

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Expert Review of Neurotherapeutics: a key contribution to decision making in the treatment of neurologic and neuropsychiatric disorders

29 August 2017

published in

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29 August 2017

volume

13

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29 August 2017

issue

6

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29 August 2017

page(s)

685-693

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https://api.crossref.org/works/10.1586%2FERN.13.59

29 August 2017

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Parkinson's disease: from monogenic forms to genetic susceptibility factors

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Parkinson's disease: mechanisms and models

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Rapid eye movement sleep behavior disorder and potassium channel antibody-associated limbic encephalitis

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Defining genetic interaction

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Identification of aberrant pathways and network activities from high-throughput data

21 January 2018

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A new methodology to associate SNPs with human diseases according to their pathway related context

21 January 2018

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Use of next-generation sequencing and other whole-genome strategies to dissect neurological disease

21 January 2018

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Integration of proteomic and metabolomic profiling as well as metabolic modeling for the functional analysis of metabolic networks

21 January 2018

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Integrated analysis of ATM mediated gene and protein expression impacting cellular metabolism.

21 January 2018

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Genomics and bioinformatics of Parkinson's disease

21 January 2018

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The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

21 January 2018

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The familial Parkinsonism gene LRRK2 regulates neurite process morphology

21 January 2018

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Dopaminergic neuronal loss, reduced neurite complexity and autophagic abnormalities in transgenic mice expressing G2019S mutant LRRK2.

21 January 2018

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LRRK2 regulates synaptic vesicle endocytosis

21 January 2018

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The Parkinson disease protein leucine-rich repeat kinase 2 transduces death signals via Fas-associated protein with death domain and caspase-8 in a cellular model of neurodegeneration

21 January 2018

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Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease

21 January 2018

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The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease

21 January 2018

1 reference

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Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease?

21 January 2018

1 reference

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Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models

21 January 2018

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Regulation of LRRK2 stability by the E3 ubiquitin ligase CHIP

21 January 2018

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Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

21 January 2018

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Time-dependent changes in GLT-1 functioning in striatum of hemi-Parkinson rats

21 January 2018

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Genome-wide association study reveals genetic risk underlying Parkinson's disease

21 January 2018

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α-Synuclein oligomers and clinical implications for Parkinson disease

21 January 2018

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Vaccination for Parkinson's disease

21 January 2018

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Aggregate formation and toxicity by wild-type and R621C synphilin-1 in the nigrostriatal system of mice using adenoviral vectors.

21 January 2018

1 reference

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Mitofusin 1 and mitofusin 2 are ubiquitinated in a PINK1/parkin-dependent manner upon induction of mitophagy

21 January 2018

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Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

21 January 2018

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The functions of UCH-L1 and its relation to neurodegenerative diseases

21 January 2018

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Parkinsonism due to mutations in PINK1, parkin, and DJ-1 and oxidative stress and mitochondrial pathways

21 January 2018

1 reference

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Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences

21 January 2018

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DJ-1 protects against dopamine toxicity: implications for Parkinson's disease and aging

21 January 2018

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Oestrogen receptors and signalling pathways: implications for neuroprotective effects of sex steroids in Parkinson's disease

21 January 2018

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The possible role of estrogen and selective estrogen receptor modulators in a rat model of Parkinson's disease

21 January 2018

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Estrogen actions in the brain and the basis for differential action in men and women: a case for sex-specific medicines

21 January 2018

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Meta-analysis of Parkinson's disease: identification of a novel locus, RIT2.

21 January 2018

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Gene expression profiles for detecting and distinguishing potential endocrine-disrupting compounds in environmental samples.

21 January 2018

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Calmodulin is a selective mediator of Ca(2+)-induced Ca2+ release via the ryanodine receptor-like Ca2+ channel triggered by cyclic ADP-ribose

21 January 2018

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Nicotinic regulation of calcium/calmodulin-dependent protein kinase II activation in the spinal cord

21 January 2018

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The combination of calmodulin antagonists and interferon-gamma induces apoptosis through caspase-dependent and -independent pathways in cholangiocarcinoma cells.

21 January 2018

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Interleukin-18 null mice show diminished microglial activation and reduced dopaminergic neuron loss following acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment

21 January 2018

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Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice.

21 January 2018

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Large-scale replication and heterogeneity in Parkinson disease genetic loci

21 January 2018

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Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database

21 January 2018

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Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

21 January 2018

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WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

21 January 2018

1 reference

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α-Synuclein promotes clathrin-mediated NMDA receptor endocytosis and attenuates NMDA-induced dopaminergic cell death

21 January 2018

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Cause-effect relationships in medicine: a protein network perspective

21 January 2018

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Revisiting lab-on-a-chip technology for drug discovery.

21 January 2018

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Lateral patch-clamping in a standard 1536-well microplate format

21 January 2018

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Ion channel electrophysiology via integrated planar patch-clamp chip with on-demand drug exchange

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Droplet microfluidic technology for single-cell high-throughput screening

21 January 2018

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Multiplexed, high-throughput analysis of 3D microtissue suspensions

21 January 2018

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A microfluidic array for large-scale ordering and orientation of embryos

21 January 2018

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Drosophila as a model to study mitochondrial dysfunction in Parkinson's disease

21 January 2018

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RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

21 January 2018

1 reference

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Calcium entry induces mitochondrial oxidant stress in vagal neurons at risk in Parkinson's disease

21 January 2018

1 reference

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Involvement of interferon-gamma in microglial-mediated loss of dopaminergic neurons.

21 January 2018

1 reference

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IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson's disease

21 January 2018

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Interferon-γ induces progressive nigrostriatal degeneration and basal ganglia calcification

21 January 2018

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Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease

21 January 2018

1 reference

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Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export.

21 January 2018

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Phosphorylation of microtubule-associated protein tau by Ca2+/calmodulin-dependent protein kinase II in its tubulin binding sites

21 January 2018

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Mitochondrial transport in neurons: impact on synaptic homeostasis and neurodegeneration

21 January 2018

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PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease

21 January 2018

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PGC-1α negatively regulates extrasynaptic NMDAR activity and excitotoxicity

21 January 2018

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The ubiquitin pathway in Parkinson's disease

21 January 2018

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Ubiquitinylation of α-synuclein by carboxyl terminus Hsp70-interacting protein (CHIP) is regulated by Bcl-2-associated athanogene 5 (BAG5).

21 January 2018

1 reference

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Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease

21 January 2018

1 reference

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Synphilin-1 inhibits alpha-synuclein degradation by the proteasome

21 January 2018

1 reference

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Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner

21 January 2018

1 reference

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The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity

21 January 2018

1 reference

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Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription

21 January 2018

1 reference

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GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons

21 January 2018

1 reference

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Foveal vision is impaired in Parkinson's disease

21 January 2018

1 reference

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Hearing impairment in Parkinson's disease: expanding the nonmotor phenotype

21 January 2018

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21 January 2018

Identifiers

DOI

10.1586/ERN.13.59

1 reference

release_gsld62b4pfdqfg27juznt7squ4

29 August 2017

Fatcat ID

1 reference

Fatcat

https://api.fatcat.wiki/v0/release/gsld62b4pfdqfg27juznt7squ4

mapped directly with Wikidata item

24 November 2022

based on heuristic

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