New biomarkers and targets in pancreatic cancer and their application to treatment (Q38021692)

27 August 2017

title

New biomarkers and targets in pancreatic cancer and their application to treatment (English)

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27 August 2017

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Eithne Costello

1

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John P Neoptolemos

object named as

John P Neoptolemos

series ordinal

3

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William Greenhalf

series ordinal

2

object named as

William Greenhalf

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27 August 2017

language of work or name

English

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publication date

26 June 2012

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Nature Reviews Gastroenterology & Hepatology

27 August 2017

published in

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27 August 2017

volume

9

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27 August 2017

issue

8

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27 August 2017

page(s)

435-444

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Estimates of cancer incidence and mortality in Europe in 2008.

27 August 2017

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Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma

21 January 2018

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Human equilibrative nucleoside transporter 1 levels predict response to gemcitabine in patients with pancreatic cancer.

21 January 2018

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Fluorouracil vs gemcitabine chemotherapy before and after fluorouracil-based chemoradiation following resection of pancreatic adenocarcinoma: a randomized controlled trial

21 January 2018

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Fluorouracil-based chemoradiation with either gemcitabine or fluorouracil chemotherapy after resection of pancreatic adenocarcinoma: 5-year analysis of the U.S. Intergroup/RTOG 9704 phase III trial

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Deoxycitidine kinase is associated with prolonged survival after adjuvant gemcitabine for resected pancreatic adenocarcinoma

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The role of HuR in gemcitabine efficacy in pancreatic cancer: HuR Up-regulates the expression of the gemcitabine metabolizing enzyme deoxycytidine kinase.

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Is there a role for the quantification of RRM1 and ERCC1 expression in pancreatic ductal adenocarcinoma?

21 January 2018

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MicroRNA-21 in pancreatic cancer: correlation with clinical outcome and pharmacologic aspects underlying its role in the modulation of gemcitabine activity.

21 January 2018

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Identification of microRNA-21 as a biomarker for chemoresistance and clinical outcome following adjuvant therapy in resectable pancreatic cancer

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MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma

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Detection of circulating tumor cells in patients with pancreatic cancer: a preliminary result

21 January 2018

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Stromal biology and therapy in pancreatic cancer.

21 January 2018

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21 January 2018

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21 January 2018

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Cancer-associated stromal fibroblasts promote pancreatic tumor progression

21 January 2018

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Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

21 January 2018

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21 January 2018

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Gemcitabine plus nab-paclitaxel is an active regimen in patients with advanced pancreatic cancer: a phase I/II trial

21 January 2018

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nab-Paclitaxel potentiates gemcitabine activity by reducing cytidine deaminase levels in a mouse model of pancreatic cancer

21 January 2018

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Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice

21 January 2018

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The variable phenotype of the p.A16V mutation of cationic trypsinogen (PRSS1) in pancreatitis families

21 January 2018

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Ras protein farnesyltransferase: A strategic target for anticancer therapeutic development

21 January 2018

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Novel approaches to target pancreatic cancer

21 January 2018

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Targeted agents in the treatment of pancreatic cancer: history and lessons learned

21 January 2018

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Molecular predictors of outcome in a phase 3 study of gemcitabine and erlotinib therapy in patients with advanced pancreatic cancer: National Cancer Institute of Canada Clinical Trials Group Study PA.3.

21 January 2018

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Coordinated epidermal growth factor receptor pathway gene overexpression predicts epidermal growth factor receptor inhibitor sensitivity in pancreatic cancer

21 January 2018

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New treatment options for advanced pancreatic cancer

21 January 2018

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Targeting the cancer initiating cell: the ultimate target for cancer therapy.

21 January 2018

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Development and characterization of gemcitabine-resistant pancreatic tumor cells.

21 January 2018

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Notch signalling in solid tumours: a little bit of everything but not all the time

21 January 2018

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Targeting Notch signaling in pancreatic cancer

21 January 2018

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Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma

21 January 2018

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Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma

21 January 2018

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KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma.

21 January 2018

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Cancer. Breaching the cancer fortress

21 January 2018

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Hedgehog inhibition prolongs survival in a genetically engineered mouse model of pancreatic cancer

21 January 2018

1 reference

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An orally bioavailable small-molecule inhibitor of Hedgehog signaling inhibits tumor initiation and metastasis in pancreatic cancer.

21 January 2018

1 reference

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CD40 agonists alter tumor stroma and show efficacy against pancreatic carcinoma in mice and humans

21 January 2018

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PARP inhibition: PARP1 and beyond

21 January 2018

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The G691S RET polymorphism increases glial cell line-derived neurotrophic factor-induced pancreatic cancer cell invasion by amplifying mitogen-activated protein kinase signaling.

21 January 2018

1 reference

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Expression of glial cell line-derived neurotrophic factor family members and their receptors in pancreatic cancers

21 January 2018

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Vandetanib in patients with locally advanced or metastatic medullary thyroid cancer: a randomized, double-blind phase III trial

21 January 2018

1 reference

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Baseline Circulating Tumor Cell Counts Significantly Enhance a Prognostic Score for Patients Participating in Phase I Oncology Trials

21 January 2018

1 reference

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New approaches to the treatment of pancreatic cancer: from tumor-directed therapy to immunotherapy

21 January 2018

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Understanding metastasis in pancreatic cancer: a call for new clinical approaches

21 January 2018

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31 March 2020

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The role of stroma in pancreatic cancer: diagnostic and therapeutic implications

31 March 2020

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Enhancing the translation of cancer biomarkers

31 March 2020

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microRNAs as markers of survival and chemoresistance in pancreatic ductal adenocarcinoma

31 March 2020

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Molecular detection of circulating cancer cells during surgery in patients with biliary-pancreatic cancer

31 March 2020

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Peritumoral fibroblast SPARC expression and patient outcome with resectable pancreatic adenocarcinoma

31 March 2020

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Molecular analysis to detect pancreatic ductal adenocarcinoma in high-risk groups

31 March 2020

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Cancer stem cells: an evolving concept

31 March 2020

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https://api.crossref.org/works/10.1038%2FNRGASTRO.2012.119

c-Met is a marker of pancreatic cancer stem cells and therapeutic target

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2012.119

The hedgehog pathway and pancreatic cancer

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2012.119

BRCA2 germline mutations in familial pancreatic carcinoma

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRGASTRO.2012.119

Familial pancreatic cancer--current knowledge

31 March 2020

1 reference

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Evidence for the efficacy of Iniparib, a PARP-1 inhibitor, in BRCA2-associated pancreatic cancer

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/22733351

12 December 2020

HuR status is a powerful marker for prognosis and response to gemcitabine-based chemotherapy for resected pancreatic ductal adenocarcinoma patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/22733351

12 December 2020

K-ras mutations in pancreatic ductal proliferative lesions

1 reference

https://pubmed.ncbi.nlm.nih.gov/22733351

12 December 2020

Targeting notch to eradicate pancreatic cancer stem cells for cancer therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22733351

12 December 2020

Gemcitabine: a modulator of intracellular nucleotide and deoxynucleotide metabolism

1 reference

https://pubmed.ncbi.nlm.nih.gov/22733351

12 December 2020

Biology and management of pancreatic cancer

1 reference

https://pubmed.ncbi.nlm.nih.gov/22733351

12 December 2020

10.1038/NRGASTRO.2012.119

Identifiers

DOI

1 reference

27 August 2017

1 reference