Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia (Q38021416)

27 August 2017

title

Consequences of a mutation in the UNC119 gene for T cell function in idiopathic CD4 lymphopenia (English)

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idiopathic CD4 lymphocytopenia

27 August 2017

main subject

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Magdalena M Gorska

1

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27 August 2017

Rafeul Alam

series ordinal

2

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27 August 2017

publication date

1 October 2012

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Current Allergy and Asthma Reports

27 August 2017

published in

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27 August 2017

volume

12

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27 August 2017

issue

5

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27 August 2017

page(s)

396-401

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Idiopathic CD4 lymphocytopenia

27 August 2017

cites work

1 reference

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Unexplained opportunistic infections and CD4+ T-lymphocytopenia without HIV infection. An investigation of cases in the United States. The Centers for Disease Control Idiopathic CD4+ T-lymphocytopenia Task Force

21 January 2018

1 reference

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A mutation in the human Uncoordinated 119 gene impairs TCR signaling and is associated with CD4 lymphopenia

21 January 2018

1 reference

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Second messenger role for Mg2+ revealed by human T-cell immunodeficiency

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-012-0281-4

Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors

21 January 2018

1 reference

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Idiopathic CD4+ T-lymphocytopenia--four patients with opportunistic infections and no evidence of HIV infection

21 January 2018

1 reference

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Idiopathic CD4+ T-lymphocytopenia--an analysis of five patients with unexplained opportunistic infections

21 January 2018

1 reference

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Apoptotic depletion of CD4+ T cells in idiopathic CD4+ T lymphocytopenia

21 January 2018

1 reference

https://api.crossref.org/works/10.1007%2FS11882-012-0281-4

Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4.

21 January 2018

1 reference

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Decreased interleukin 7 responsiveness of T lymphocytes in patients with idiopathic CD4 lymphopenia

21 January 2018

1 reference

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Defective p56Lck activity in T cells from an adult patient with idiopathic CD4+ lymphocytopenia

21 January 2018

1 reference

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Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

21 January 2018

1 reference

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T-cell receptor proximal signaling via the Src-family kinases, Lck and Fyn, influences T-cell activation, differentiation, and tolerance

21 January 2018

1 reference

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Profound block in thymocyte development in mice lacking p56lck

21 January 2018

1 reference

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Defective expression of p56lck in an infant with severe combined immunodeficiency

21 January 2018

1 reference

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Identification of UNC119 as a novel activator of SRC-type tyrosine kinases

21 January 2018

1 reference

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Uncoordinated 119 protein controls trafficking of Lck via the Rab11 endosome and is critical for immunological synapse formation.

21 January 2018

1 reference

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Uncoordinated 119 preferentially induces Th2 differentiation and promotes the development of asthma

21 January 2018

1 reference

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Crystal structure of the Src family tyrosine kinase Hck

21 January 2018

1 reference

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Three-dimensional structure of the tyrosine kinase c-Src

21 January 2018

1 reference

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Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor

21 January 2018

1 reference

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Activation of the Src-family tyrosine kinase Hck by SH3 domain displacement

21 January 2018

1 reference

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More than just SCID--the phenotypic range of combined immunodeficiencies associated with mutations in the recombinase activating genes (RAG) 1 and 2.

21 January 2018

1 reference

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RAG-dependent primary immunodeficiencies.

21 January 2018

1 reference

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Changes in retinal synaptic proteins in the transgenic model expressing a mutant HRG4 (UNC119).

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

Dephosphorylation and activation of the T cell tyrosine kinase pp56lck by the leukocyte common antigen (CD45).

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

Idiopathic CD4+ lymphocytopenia may be due to decreased bone marrow clonogenic capability

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

HRG4 (UNC119) mutation found in cone-rod dystrophy causes retinal degeneration in a transgenic model

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

Two patients with cryptococcal meningitis and idiopathic CD4 lymphopenia: defective cytokine production and reversal by recombinant interferon- gamma therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

Unc119, a novel activator of Lck/Fyn, is essential for T cell activation

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

Defect of lck in a patient with common variable immunodeficiency

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

Idiopathic CD4+ T lymphopenia without autoimmunity or granulomatous disease in the slipstream of RAG mutations

1 reference

https://pubmed.ncbi.nlm.nih.gov/22729960

12 December 2020

10.1007/S11882-012-0281-4

Identifiers

DOI

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Dimensions Publication ID

27 August 2017

1017407740

0 references

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