Building strong bones: molecular regulation of the osteoblast lineage (Q37970567)

26 August 2017

title

Building strong bones: molecular regulation of the osteoblast lineage (English)

1 reference

26 August 2017

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Fanxin Long

1

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26 August 2017

publication date

22 December 2011

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Nature Reviews Molecular Cell Biology

26 August 2017

published in

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26 August 2017

volume

13

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26 August 2017

issue

1

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26 August 2017

page(s)

27-38

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The FGF23-Klotho axis: endocrine regulation of phosphate homeostasis

26 August 2017

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1 reference

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Wnt/beta-catenin signaling in mesenchymal progenitors controls osteoblast and chondrocyte differentiation during vertebrate skeletogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Canonical Wnt/beta-catenin signaling prevents osteoblasts from differentiating into chondrocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Lrp5 and Lrp6 redundantly control skeletal development in the mouse embryo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Wnt/beta-catenin signaling interacts differentially with Ihh signaling in controlling endochondral bone and synovial joint formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Noncanonical Wnt signaling through G protein-linked PKCdelta activation promotes bone formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

A histone lysine methyltransferase activated by non-canonical Wnt signalling suppresses PPAR-gamma transactivation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Inhibition of adipogenesis by Wnt signaling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Control of bone formation by the serpentine receptor Frizzled-9

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Specificity and versatility in tgf-beta signaling through Smads

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Genetic analysis of the roles of BMP2, BMP4, and BMP7 in limb patterning and skeletogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

BMP signaling negatively regulates bone mass through sclerostin by inhibiting the canonical Wnt pathway.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Disruption of BMP signaling in osteoblasts through type IA receptor (BMPRIA) increases bone mass.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Wnt inhibitors Dkk1 and Sost are downstream targets of BMP signaling through the type IA receptor (BMPRIA) in osteoblasts.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Bone morphogenetic protein type IA receptor signaling regulates postnatal osteoblast function and bone remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Skeletal Overexpression of Noggin Results in Osteopenia and Reduced Bone Formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Smad4 is required for maintaining normal murine postnatal bone homeostasis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Bone morphogenetic protein-3 is a negative regulator of bone density

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

BMP3 suppresses osteoblast differentiation of bone marrow stromal cells via interaction with Acvr2b.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Functional evolutionary history of the mouse Fgf gene family

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Cellular signaling by fibroblast growth factor receptors

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Disruption of the fibroblast growth factor-2 gene results in decreased bone mass and bone formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

A gain-of-function mutation of Fgfr2c demonstrates the roles of this receptor variant in osteogenesis.

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Defective bone mineralization and osteopenia in young adult FGFR3-/- mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

The mature osteoblast phenotype is characterized by extensive plasticity

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Leptin regulates bone formation via the sympathetic nervous system

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

A serotonin-dependent mechanism explains the leptin regulation of bone mass, appetite, and energy expenditure

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Skeletal phenotype of the leptin receptor-deficient db/db mouse

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Leptin acts on human marrow stromal cells to enhance differentiation to osteoblasts and to inhibit differentiation to adipocytes

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Leptin directly regulates bone cell function in vitro and reduces bone fragility in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Dissociation of the neuronal regulation of bone mass and energy metabolism by leptin in vivo

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Parathyroid hormone stimulates the bone apposition rate independently of its resorptive action: differential effects of intermittent and continuous administration

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Suppression of Wnt signaling by Dkk1 attenuates PTH-mediated stromal cell response and new bone formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

The effects of parathyroid hormone and alendronate alone or in combination in postmenopausal osteoporosis

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Inhibition of Sca-1-Positive Skeletal Stem Cell Recruitment by Alendronate Blunts the Anabolic Effects of Parathyroid Hormone on Bone Remodeling

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

TGF-beta1-induced migration of bone mesenchymal stem cells couples bone resorption with formation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Growth hormone, insulin-like growth factors, and the skeleton

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Mode of growth hormone action in osteoblasts

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Osteoblast-specific knockout of the insulin-like growth factor (IGF) receptor gene reveals an essential role of IGF signaling in bone matrix mineralization

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Targeted overexpression of insulin-like growth factor I to osteoblasts of transgenic mice: increased trabecular bone volume without increased osteoblast proliferation

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Suppressive function of androgen receptor in bone resorption

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Relative impact of androgen and estrogen receptor activation in the effects of androgens on trabecular and cortical bone in growing male mice: a study in the androgen receptor knockout mouse model

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

A functional androgen receptor is not sufficient to allow estradiol to protect bone after gonadectomy in estradiol receptor-deficient mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Distinct effects of loss of classical estrogen receptor signaling versus complete deletion of estrogen receptor alpha on bone

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRM3254

Stromal stem cells: marrow-derived osteogenic precursors

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

Stromal mechanisms of bone marrow: cloning in vitro and retransplantation in vivo.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

A cytological and histochemical study of bone and cartilage formation in the rat.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

Gli2, but not Gli1, is required for initial Shh signaling and ectopic activation of the Shh pathway

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

The IIIc alternative of Fgfr2 is a positive regulator of bone formation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

THE FINE STRUCTURE OF BONE CELLS.

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

Hoxa-2 restricts the chondrogenic domain and inhibits bone formation during development of the branchial area

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

The murine Bapx1 homeobox gene plays a critical role in embryonic development of the axial skeleton and spleen

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

Specific and redundant functions of Gli2 and Gli3 zinc finger genes in skeletal patterning and development

1 reference

https://pubmed.ncbi.nlm.nih.gov/22189423

12 December 2020

Identifiers

DOI

10.1038/NRM3254

1 reference

Dimensions Publication ID

26 August 2017

1004042863

0 references

1 reference