Novel ocular antihypertensive compounds in clinical trials (Q37883078)

24 August 2017

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title

Novel ocular antihypertensive compounds in clinical trials (English)

1 reference

24 August 2017

June Chen

1

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24 August 2017

Stephen A Runyan

series ordinal

2

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24 August 2017

Michael R Robinson

series ordinal

3

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24 August 2017

language of work or name

English

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publication date

20 May 2011

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24 August 2017

Clinical Ophthalmology

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24 August 2017

5

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24 August 2017

667-677

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Creative Commons Attribution-NonCommercial 3.0 Unported

24 August 2017

start time

1 May 2011

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

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Characterization of cytoskeleton-enriched protein fraction of the trabecular meshwork and ciliary muscle cells

6 September 2017

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Programs to optimize adherence in glaucoma

6 September 2017

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Delivery of siRNA therapeutics: barriers and carriers

6 September 2017

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Treatment of dry eye syndrome with orally administered CF101: data from a phase 2 clinical trial

6 September 2017

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Adenosine receptors as drug targets

6 September 2017

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Actin, a central player in cell shape and movement

6 September 2017

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Unpredictability of glaucoma progression

6 September 2017

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Selective serotonin reuptake inhibitors: a review of its effects on intraocular pressure

6 September 2017

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Quantifying the effect of intraocular pressure reduction on the occurrence of glaucoma

6 September 2017

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Does the renin-angiotensin system also regulate intra-ocular pressure?

6 September 2017

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The promises and pitfalls of RNA-interference-based therapeutics

6 September 2017

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Uveoscleral outflow--a review

6 September 2017

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Structural changes of the trabecular meshwork in different kinds of glaucoma

6 September 2017

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The role of the actomyosin system in regulating trabecular fluid outflow

6 September 2017

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Insights into the regulation of 5-HT2A serotonin receptors by scaffolding proteins and kinases

6 September 2017

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6 September 2017

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Mechanism of action of bimatoprost, latanoprost, and travoprost in healthy subjects. A crossover study

6 September 2017

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Normal-tension glaucoma: is it different from primary open-angle glaucoma?

6 September 2017

1 reference

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Applications for ROCK kinase inhibition

6 September 2017

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The A3 adenosine receptor: an enigmatic player in cell biology

6 September 2017

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In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models

6 September 2017

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History of cannabis and its preparations in saga, science, and sobriquet

6 September 2017

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Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Cell-specific differential modulation of human trabecular meshwork cells by selective adenosine receptor agonists

6 September 2017

1 reference

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Aqueous humor outflow: what do we know? Where will it lead us?

6 September 2017

1 reference

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The endocannabinoid system as an emerging target of pharmacotherapy

6 September 2017

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The prostanoid EP2 receptor agonist butaprost increases uveoscleral outflow in the cynomolgus monkey

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Causal inference in primary open angle glaucoma: specific discussion on intraocular pressure

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Swelling-activated chloride channels in aqueous humour formation: on the one side and the other

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

A sick eye in a sick body? Systemic findings in patients with primary open-angle glaucoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Adenosine receptors as therapeutic targets

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

'What controls aqueous humour outflow resistance?'.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

The structure of dimeric ROCK I reveals the mechanism for ligand selectivity

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Rho GTPases and the control of cell behaviour

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Development of specific Rho-kinase inhibitors and their clinical application

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Changes in aqueous humor dynamics with age and glaucoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Rho kinase, a promising drug target for neurological disorders

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effect of CS-088, an angiotensin AT1 receptor antagonist, on intraocular pressure in glaucomatous monkey eyes

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

A computational study of off-target effects of RNA interference

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effects of latrunculin B on outflow facility, intraocular pressure, corneal thickness, and miotic and accommodative responses to pilocarpine in monkeys

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Cannabinoids and glaucoma

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Rocks: multifunctional kinases in cell behaviour

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Evaluation of the ocular hypotensive response of serotonin 5-HT1A and 5-HT2 receptor ligands in conscious ocular hypertensive cynomolgus monkeys

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effect of WIN 55212-2, a cannabinoid receptor agonist, on aqueous humor dynamics in monkeys

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Renin-angiotensin system expression and secretory function in cultured human ciliary body non-pigmented epithelium.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Adenosine receptors: G protein-mediated signalling and the role of accessory proteins.

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Paradoxical trafficking and regulation of 5-HT(2A) receptors by agonists and antagonists

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cells

6 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

The renin-angiotensin system in retinal health and disease: Its influence on neurons, glia and the vasculature

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Mechanisms linking adenosine A1 receptors and extracellular signal-regulated kinase 1/2 activation in human trabecular meshwork cells

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Ocular hypotensive effect of the Rho kinase inhibitor AR-12286 in patients with glaucoma and ocular hypertension

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Stimulation of cannabinoid (CB1) and prostanoid (EP2) receptors opens BKCa channels and relaxes ocular trabecular meshwork

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Cannabinoid CB(1) receptor expression, activation and detection of endogenous ligand in trabecular meshwork and ciliary process tissues

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Inhibition of actin polymerization by latrunculin A.

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

The glaucoma research community and FDA look to the future: a report from the NEI/FDA CDER Glaucoma Clinical Trial Design and Endpoints Symposium

23 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

The treatment of normal-tension glaucoma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effects of latrunculin-B on outflow facility and trabecular meshwork structure in human eyes.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Aqueous humor dynamics in monkeys after topical R-DOI.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Modulation of conventional outflow facility by the adenosine A1 agonist N6-cyclohexyladenosine

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Rho-associated protein kinase inhibitor, Y-27632, induces alterations in adhesion, contraction and motility in cultured human trabecular meshwork cells

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Latrunculin B effects on trabecular meshwork and corneal endothelial morphology in monkeys.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Contribution of ROCK in contraction of trabecular meshwork: proposed mechanism for regulating aqueous outflow in monkey and human eyes

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effect of low-dose latrunculin B on anterior segment physiologic features in the monkey eye.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Structure-activity relationships of adenosine A3 receptor ligands: new potential therapy for the treatment of glaucoma

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Common actions of adenosine receptor agonists in modulating human trabecular meshwork cell transport

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effects of serotonergic compounds on aqueous humor dynamics in monkeys

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Involvement of phosphorylation of myosin phosphatase by ROCK in trabecular meshwork and ciliary muscle contraction

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effects of cytochalasin D and latrunculin B on mechanical properties of cells.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Effects of adenosine agonists on intraocular pressure and aqueous humor dynamics in cynomolgus monkeys.

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Guide to Receptors and Channels (GRAC), 4th Edition

1 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

Primary open-angle glaucoma

1 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3104796

New anti-actin drugs in the study of the organization and function of the actin cytoskeleton

5 November 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/21629573

12 December 2020

Latrunculins' effects on intraocular pressure, aqueous humor flow, and corneal endothelium

1 reference

https://pubmed.ncbi.nlm.nih.gov/21629573

12 December 2020

Effects of topical administration of y-39983, a selective rho-associated protein kinase inhibitor, on ocular tissues in rabbits and monkeys

1 reference

https://pubmed.ncbi.nlm.nih.gov/21629573

12 December 2020

Development of tolerance to the antihypertensive effects of highly selective adenosine A2a agonists upon chronic administration

1 reference

https://pubmed.ncbi.nlm.nih.gov/21629573

12 December 2020

Intraocular pressure-lowering effects and safety of topical administration of a selective ROCK inhibitor, SNJ-1656, in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/21629573

12 December 2020

A3 adenosine receptors regulate Cl- channels of nonpigmented ciliary epithelial cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/21629573

12 December 2020

Identifiers

DOI

10.2147/OPTH.S15971

1 reference

24 August 2017

1 reference

24 August 2017

PubMed publication ID

21629573

1 reference