Sirt1's systemic protective roles and its promise as a target in antiaging medicine (Q37865873)

24 August 2017

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title

Sirt1's systemic protective roles and its promise as a target in antiaging medicine (English)

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24 August 2017

Bor Luen Tang

1

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24 August 2017

publication date

28 December 2010

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24 August 2017

published in

Translational Research

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24 August 2017

volume

157

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24 August 2017

issue

5

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24 August 2017

page(s)

276-284

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A therapeutic role for sirtuins in diseases of aging?

24 August 2017

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SIRT1 deacetylates and positively regulates the nuclear receptor LXR

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PTEN acetylation modulates its interaction with PDZ domain

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SIRT1 interacts with p73 and suppresses p73-dependent transcriptional activity

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SIRT1 Regulates UV-Induced DNA Repair through Deacetylating XPA

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Sirt1 regulates aging and resistance to oxidative stress in the heart

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SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1

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Exogenous NAD blocks cardiac hypertrophic response via activation of the SIRT3-LKB1-AMP-activated kinase pathway

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SIRT3 is a stress-responsive deacetylase in cardiomyocytes that protects cells from stress-mediated cell death by deacetylation of Ku70

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Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice

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Paths of convergence: sirtuins in aging and neurodegeneration

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Brain SIRT1: anatomical distribution and regulation by energy availability

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SIRT1 Promotes the Central Adaptive Response to Diet Restriction through Activation of the Dorsomedial and Lateral Nuclei of the Hypothalamus

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Neuronal SIRT1 regulates endocrine and behavioral responses to calorie restriction

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SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against diet-induced obesity

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Distribution analysis of deacetylase SIRT1 in rodent and human nervous systems

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The interaction between FOXO and SIRT1: tipping the balance towards survival

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Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons.

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C. elegans model identifies genetic modifiers of alpha-synuclein inclusion formation during aging

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SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling

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Caloric restriction attenuates beta-amyloid neuropathology in a mouse model of Alzheimer's disease

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Modulation of statin-activated shedding of Alzheimer APP ectodomain by ROCK

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Alzheimer's disease: channeling APP to non-amyloidogenic processing

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Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction

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SIRT1 suppresses beta-amyloid production by activating the alpha-secretase gene ADAM10.

7 January 2021

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SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

7 January 2021

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Resveratrol is neuroprotective because it is not a direct activator of Sirt1-A hypothesis

7 January 2021

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Silent information regulator 2 (SIRT1) attenuates oxidative stress-induced mesangial cell apoptosis via p53 deacetylation

7 January 2021

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SIRT1 inhibits transforming growth factor beta-induced apoptosis in glomerular mesangial cells via Smad7 deacetylation

7 January 2021

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Resveratrol inhibits renal fibrosis in the obstructed kidney: potential role in deacetylation of Smad3

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Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression

7 January 2021

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Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function

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Sirt1 activation protects the mouse renal medulla from oxidative injury

7 January 2021

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Calorie restriction enhances cell adaptation to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney

7 January 2021

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Age-dependent changes of the kidneys: pharmacological implications

7 January 2021

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Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct

7 January 2021

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Aldosterone-sensitive repression of ENaCalpha transcription by a histone H3 lysine-79 methyltransferase

7 January 2021

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Sirtuins: critical regulators at the crossroads between cancer and aging

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Tumor suppressor HIC1 directly regulates SIRT1 to modulate p53-dependent DNA-damage responses

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DBC1 is a negative regulator of SIRT1

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Negative regulation of the deacetylase SIRT1 by DBC1

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Balance between SIRT1 and DBC1 expression is lost in breast cancer.

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Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival.

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Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage

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Control of multidrug resistance gene mdr1 and cancer resistance to chemotherapy by the longevity gene sirt1.

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Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase

7 January 2021

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The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

7 January 2021

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A c-Myc-SIRT1 feedback loop regulates cell growth and transformation.

7 January 2021

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SirT1 is an inhibitor of proliferation and tumor formation in colon cancer

7 January 2021

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Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice

7 January 2021

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Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis

7 January 2021

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Cancer chemopreventive and therapeutic potential of resveratrol: mechanistic perspectives

7 January 2021

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Multiple molecular targets of resveratrol: Anti-carcinogenic mechanisms

7 January 2021

1 reference

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SirT1-null mice develop tumors at normal rates but are poorly protected by resveratrol

7 January 2021

1 reference

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Cortactin: Coordinating adhesion and the actin cytoskeleton at cellular protrusions

7 January 2021

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HDAC6 modulates cell motility by altering the acetylation level of cortactin

7 January 2021

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Therapeutic potential of resveratrol: the in vivo evidence

7 January 2021

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Resveratrol improves health and survival of mice on a high-calorie diet

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2010.11.006

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2010.11.006

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2010.11.006

Salermide, a Sirtuin inhibitor with a strong cancer-specific proapoptotic effect.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FJ.TRSL.2010.11.006

10.1016/J.TRSL.2010.11.006

7 January 2021

Identifiers

DOI

1 reference

24 August 2017

1 reference