Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action (Q37650120)

21 August 2017

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title

Intracellular Pharmacokinetics of Antiretroviral Drugs in HIV-Infected Patients, and their Correlation with Drug Action (English)

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21 August 2017

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anti-retroviral agent

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1 reference

6

Anne-Marie Taburet

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21 August 2017

5

France Mentré

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21 August 2017

Caroline Bazzoli

1

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21 August 2017

Vincent Jullien

series ordinal

2

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21 August 2017

Clotilde Le Tiec

series ordinal

3

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21 August 2017

Elisabeth Rey

series ordinal

4

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21 August 2017

publication date

1 January 2010

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Clinical Pharmacokinetics

21 August 2017

published in

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21 August 2017

volume

49

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21 August 2017

issue

1

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21 August 2017

page(s)

17-45

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Pharmacokinetics of zidovudine phosphorylation in peripheral blood mononuclear cells from patients infected with human immunodeficiency virus

21 August 2017

cites work

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21 January 2018

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12 December 2020

The durability of virological success of tenofovir and didanosine dosed at either 400 or 250 mg once daily

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12 December 2020

The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites

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12 December 2020

Protein binding in antiretroviral therapies

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12 December 2020

Suboptimal CD4 gains in HIV-infected patients receiving didanosine plus tenofovir

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12 December 2020

Complications associated with NRTI therapy: update on clinical features and possible pathogenic mechanisms.

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12 December 2020

Quantitation of zidovudine triphosphate concentrations from human peripheral blood mononuclear cells by anion exchange solid phase extraction and liquid chromatography-tandem mass spectroscopy; an indirect quantitation methodology

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12 December 2020

Effects of drugs on 2',3'-dideoxy-2',3'-didehydrothymidine phosphorylation in vitro

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https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

High rate of didanosine-related mitochondrial toxicity in HIV/HCV-coinfected patients receiving ribavirin.

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https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Effect of quercetin on the plasma and intracellular concentrations of saquinavir in healthy adults

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https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacokinetics of zidovudine phosphorylation in patients infected with the human immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular measurements of anti-HIV drugs indinavir, amprenavir, saquinavir, ritonavir, nelfinavir, lopinavir, atazanavir, efavirenz and nevirapine in peripheral blood mononuclear cells by liquid chromatography coupled to tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Effect of adherence to HAART on virologic outcome and on the selection of resistance-conferring mutations in NNRTI- or PI-treated patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Zidovudine phosphorylation determined sequentially over 12 months in human immunodeficiency virus-infected patients with or without previous exposure to antiretroviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Serious adverse cutaneous and hepatic toxicities associated with nevirapine use by non-HIV-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pathogenesis of HIV-1-protease inhibitor-associated peripheral lipodystrophy, hyperlipidaemia, and insulin resistance

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Direct determination of phosphorylated intracellular anabolites of stavudine (d4T) by liquid chromatography/tandem mass spectrometry.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

High levels of zidovudine (AZT) and its intracellular phosphate metabolites in AZT- and AZT-lamivudine-treated newborns of human immunodeficiency virus-infected mothers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Treatment for adult HIV infection: 2006 recommendations of the International AIDS Society-USA panel

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

European AIDS Clinical Society (EACS) guidelines for the clinical management and treatment of chronic hepatitis B and C coinfection in HIV-infected adults.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The effect of lopinavir/ritonavir on the renal clearance of tenofovir in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Low levels of deoxynucleotides in peripheral blood lymphocytes: a strategy to inhibit human immunodeficiency virus type 1 replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular and plasma pharmacokinetics of saquinavir-ritonavir, administered at 1,600/100 milligrams once daily in human immunodeficiency virus-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Development of an assay method for the detection and quantification of protease and non-nucleoside reverse transcriptase inhibitors in plasma and in peripherical blood mononuclear cells by liquid chromatography coupled with ultraviolet or tandem mas

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The mechanism of insulin resistance caused by HIV protease inhibitor therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

HIV-associated lipodystrophy: a review of underlying mechanisms and therapeutic options

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Liquid chromatography-tandem mass spectrometric quantitative determination of the HIV protease inhibitor atazanavir (BMS-232632) in human peripheral blood mononuclear cells (PBMC): practical approaches to PBMC preparation and PBMC assay design for h

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Evidence and possible consequences of the phosphorylation of nucleoside reverse transcriptase inhibitors in human red blood cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

An inhibitor of HIV-1 protease modulates proteasome activity, antigen presentation, and T cell responses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Genetic variation in drug transporters in ethnic populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Differential extracellular and intracellular concentrations of zidovudine and lamivudine in semen and plasma of HIV-1-infected men.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacogenetics of anti-HIV drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Effect of ribavirin on intracellular and plasma pharmacokinetics of nucleoside reverse transcriptase inhibitors in patients with human immunodeficiency virus-hepatitis C virus coinfection: results of a randomized clinical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Integrase inhibitors: a new treatment option for patients with human immunodeficiency virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Atazanavir modestly increases plasma levels of raltegravir in healthy subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacokinetics and potential interactions amongst antiretroviral agents used to treat patients with HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Population pharmacokinetics and pharmacodynamics of zidovudine in HIV-infected infants and children

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Improved method for the simultaneous determination of d4T, 3TC and ddl intracellular phosphorylated anabolites in human peripheral-blood mononuclear cells using high-performance liquid chromatography/tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Transporters and drug therapy: implications for drug disposition and disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Long-term toxicity/activity profile of 2',3'-dideoxyinosine in AIDS or AIDS-related complex

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular indinavir pharmacokinetics in HIV-infected patients: comparison with plasma pharmacokinetics

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Safety, tolerability, and pharmacokinetics of raltegravir after single and multiple doses in healthy subjects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The pharmacology of antiretroviral nucleoside and nucleotide reverse transcriptase inhibitors: implications for once-daily dosing

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pilot pharmacokinetic study of human immunodeficiency virus-infected patients receiving tenofovir disoproxil fumarate (TDF): investigation of systemic and intracellular interactions between TDF and abacavir, lamivudine, or lopinavir-ritonavir

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Concentrations of zidovudine- and lamivudine-triphosphate according to cell type in HIV-seronegative adults

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

A strategy for liquid chromatography/tandem mass spectrometric assays of intracellular drugs: application to the validation of the triphosphorylated anabolite of antiretrovirals in peripheral blood mononuclear cells.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Tenofovir-associated Fanconi syndrome: review of the FDA adverse event reporting system

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular and plasma pharmacokinetics of nelfinavir and M8 in HIV-infected patients: relationship with P-glycoprotein expression

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/20000887

1 reference

12 December 2020

A review of low-dose ritonavir in protease inhibitor combination therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Influence of prior exposure to zidovudine on stavudine phosphorylation in vivo and ex vivo

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Association between ABCC2 gene haplotypes and tenofovir-induced proximal tubulopathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Incidence of liver injury after beginning antiretroviral therapy with efavirenz or nevirapine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Abcg2/Bcrp1 mediates the polarized transport of antiretroviral nucleosides abacavir and zidovudine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Quantitative immunoassay to measure plasma and intracellular atazanavir levels: analysis of drug accumulation in cultured T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Influence of atazanavir 200 mg on the intracellular and plasma pharmacokinetics of saquinavir and ritonavir 1600/100 mg administered once daily in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The plasma and intracellular steady-state pharmacokinetics of lopinavir/ritonavir in HIV-1-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Hematologic toxicity of zidovudine in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular pharmacokinetics of tenofovir diphosphate, carbovir triphosphate, and lamivudine triphosphate in patients receiving triple-nucleoside regimens

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Low response to pegylated interferon plus ribavirin in HIV-infected patients with chronic hepatitis C treated with abacavir.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Monitoring of lopinavir and ritonavir in peripheral blood mononuclear cells, plasma, and ultrafiltrate using a selective and highly sensitive LC/MS/MS assay

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Simultaneous determination of the antiretroviral agents: amprenavir, lopinavir, ritonavir, saquinavir and efavirenz in human peripheral blood mononuclear cells by high-performance liquid chromatography-mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Mechanisms of HIV and nucleoside reverse transcriptase inhibitor injury to mitochondria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Cell entry and export of nucleoside analogues

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Simultaneous quantitation of intracellular zidovudine and lamivudine triphosphates in human immunodeficiency virus-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Didanosine-associated toxicity: a predictable complication of therapy with tenofovir and didanosine?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacogenetic characteristics of indinavir, zidovudine, and lamivudine therapy in HIV-infected adults: a pilot study

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Toxicity of antiretroviral nucleoside and nucleotide analogues: is mitochondrial toxicity the only mechanism?

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Role of purine nucleoside phosphorylase in interactions between 2',3'-dideoxyinosine and allopurinol, ganciclovir, or tenofovir

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular carbovir triphosphate levels in patients taking abacavir once a day.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Therapeutic strategies towards HIV-1 infection in macrophages

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Steady-state pharmacokinetics of abacavir in plasma and intracellular carbovir triphosphate following administration of abacavir at 600 milligrams once daily and 300 milligrams twice daily in human immunodeficiency virus-infected subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Concentration-controlled compared with conventional antiretroviral therapy for HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

An MDR1-3435 variant is associated with higher plasma nelfinavir levels and more rapid virologic response in HIV-1 infected children

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Principles and practice of HIV-protease inhibitor pharmacoenhancement

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Mechanism of the potentiating effect of ribavirin on the activity of 2',3'-dideoxyinosine against human immunodeficiency virus

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Once-daily dosing of saquinavir soft-gel capsules and ritonavir combination in HIV-1-infected patients (IMEA015 study).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

P-glycoprotein and MRP1 expression and reduced ritonavir and saquinavir accumulation in HIV-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Choroid plexus controls brain availability of anti-HIV nucleoside analogs via pharmacologically inhibitable organic anion transporters

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacokinetic and pharmacodynamic characteristics of emtricitabine support its once daily dosing for the treatment of HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Mechanisms of drug transfer across the human placenta-a workshop report

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Physiological concentrations of purines and pyrimidines

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular nucleoside triphosphate concentrations in HIV-infected patients on dual nucleoside reverse transcriptase inhibitor therapy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Development of a direct assay for measuring intracellular AZT triphosphate in humans peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

HIV-associated lipodystrophy syndrome: description and pathogenesis

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacokinetic evaluation of the effects of ribavirin on zidovudine triphosphate formation: ACTG 5092s Study Team

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular studies of the nucleoside reverse transcriptase inhibitor active metabolites: a review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Metabolic abnormalities in skeletal muscle of patients receiving zidovudine therapy observed by 31P in vivo magnetic resonance spectroscopy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Switching effective antiretroviral therapy: a review.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Antiretroviral therapy in adults: updated recommendations of the International AIDS Society-USA Panel

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Modulation of human BCRP (ABCG2) activity by anti-HIV drugs

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular metabolism of zidovudine and stavudine in combination

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Measurement of intracellular didanosine and tenofovir phosphorylated metabolites and possible interaction of the two drugs in human immunodeficiency virus-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Improved method to quantify intracellular zidovudine mono- and triphosphate in peripheral blood mononuclear cells by liquid chromatography-tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The intracellular pharmacology of antiretroviral protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Liquid chromatography-tandem mass spectrometric determination of tenofovir-diphosphate in human peripheral blood mononuclear cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Activity, safety, and immunological effects of hydroxyurea added to didanosine in antiretroviral-naive and experienced HIV type 1-infected subjects: a randomized, placebo-controlled trial, ACTG 307.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Reviews of anti-infective agents: maraviroc: the first of a new class of antiretroviral agents

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Induction-maintenance antiretroviral strategies to reduce long-term toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Early virologic nonresponse to tenofovir, abacavir, and lamivudine in HIV-infected antiretroviral-naive subjects

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Monitoring of didanosine and stavudine intracellular trisphosphorylated anabolite concentrations in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Virological, intracellular and plasma pharmacological parameters predicting response to lopinavir/ritonavir (KALEPHAR study).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular accumulation of human immunodeficiency virus protease inhibitors

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Dyslipidaemia associated with antiretroviral therapy in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular and plasma pharmacokinetics of nevirapine in human immunodeficiency virus-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Fatal lactic acidosis and acute renal failure after addition of tenofovir to an antiretroviral regimen containing didanosine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular and plasma pharmacokinetics of efavirenz in HIV-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Effect of ribavirin on zidovudine efficacy and toxicity in vitro: a concentration-dependent interaction

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Effect of hydroxyurea and dideoxyinosine on intracellular 3'-deoxyadenosine-5'-triphosphate concentrations in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacokinetics, pharmacodynamics and drug interaction potential of enfuvirtide

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular and plasma efavirenz concentrations in HIV-infected patients switching from successful protease inhibitor-based highly active antiretroviral therapy (HAART) to efavirenz-based HAART (SUSTIPHAR Study)

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Simultaneous quantitation of the 5'-triphosphate metabolites of zidovudine, lamivudine, and stavudine in peripheral mononuclear blood cells of HIV infected patients by high-performance liquid chromatography tandem mass spectrometry

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Zidovudine triphosphate and lamivudine triphosphate concentration-response relationships in HIV-infected persons

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The sterol regulatory element-binding protein pathway: control of lipid homeostasis through regulated intracellular transport

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Dose-dependent influence of didanosine on immune recovery in HIV-infected patients treated with tenofovir

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Ribavirin antagonizes the effect of azidothymidine on HIV replication

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Differential modulation of P-glycoprotein expression and activity by non-nucleoside HIV-1 reverse transcriptase inhibitors in cell culture

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Simultaneous measurement of intracellular triphosphate metabolites of zidovudine, lamivudine and abacavir (carbovir) in human peripheral blood mononuclear cells by combined anion exchange solid phase extraction and LC-MS/MS

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Specificity enhancement with LC-positive ESI-MS/MS for the measurement of nucleotides: application to the quantitative determination of carbovir triphosphate, lamivudine triphosphate and tenofovir diphosphate in human peripheral blood mononuclear ce

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Peripheral blood mononuclear cell counting using a DNA-detection-based method

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Systemic pharmacokinetics and cellular pharmacology of zidovudine in human immunodeficiency virus type 1-infected women and newborn infants

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Predictors of HIV drug-resistance mutations in a large antiretroviral-naive cohort initiating triple antiretroviral therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Effect of Lamivudine on the plasma and intracellular pharmacokinetics of apricitabine, a novel nucleoside reverse transcriptase inhibitor, in healthy volunteers

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Ten years of highly active antiretroviral therapy for HIV infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Influence of development, HIV infection, and antiretroviral therapies on the gene expression profiles of ABC transporters in human lymphocytes

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular pharmacokinetics of once versus twice daily zidovudine and lamivudine in adolescents.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Thymidine and 3'-azido-3'-deoxythymidine metabolism in human peripheral blood lymphocytes and monocyte-derived macrophages. A study of both anabolic and catabolic pathways

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Explaining variability in the relationship between antiretroviral adherence and HIV mutation accumulation

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Expression of adenosine triphosphate-binding cassette (ABC) drug transporters in peripheral blood cells: relevance for physiology and pharmacotherapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Drug interactions with new and investigational antiretrovirals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The impact of sex and contraceptive therapy on the plasma and intracellular pharmacokinetics of zidovudine

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Clinical pharmacokinetics of zidovudine: inter and intraindividual variability and relationship to long term efficacy and toxicity.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Intracellular concentration of protease inhibitors in HIV-1-infected patients: correlation with MDR-1 gene expression and low dose of ritonavir

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Pharmacokinetics of antiretroviral regimens containing tenofovir disoproxil fumarate and atazanavir-ritonavir in adolescents and young adults with human immunodeficiency virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Expression and functionality of anti-human immunodeficiency virus and anticancer drug uptake transporters in immune cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Clinical and genetic determinants of intracellular tenofovir diphosphate concentrations in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Population pharmacokinetics and effects of efavirenz in patients with human immunodeficiency virus infection

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Prototype trial design for rapid dose selection of antiretroviral drugs: an example using emtricitabine (Coviracil).

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Effect of mycophenolate mofetil on the pharmacokinetics of antiretroviral drugs and on intracellular nucleoside triphosphate pools

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Systematic and comprehensive strategy for reducing matrix effects in LC/MS/MS analyses

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

An enzyme immunoassay for the quantification of plasma and intracellular lopinavir in HIV-infected patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Correlates of zidovudine phosphorylation with markers of HIV disease progression and drug toxicity

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Risk factors for symptomatic mitochondrial toxicity in HIV/hepatitis C virus-coinfected patients during interferon plus ribavirin-based therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

In vivo antagonism with zidovudine plus stavudine combination therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The transport of anti-HIV drugs across blood-CNS interfaces: summary of current knowledge and recommendations for further research.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The role of efavirenz compared with protease inhibitors in the body fat changes associated with highly active antiretroviral therapy

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

High virological failure rate in HIV patients after switching to a regimen with two nucleoside reverse transcriptase inhibitors plus tenofovir.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

The effect of ABCB1 polymorphism on the pharmacokinetics of saquinavir alone and in combination with ritonavir.

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Antiviral dynamics and sex differences of zidovudine and lamivudine triphosphate concentrations in HIV-infected individuals

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

Zidovudine phosphorylation and mitochondrial toxicity in vitro

1 reference

https://pubmed.ncbi.nlm.nih.gov/20000887

12 December 2020

10.2165/11318110-000000000-00000

Identifiers

DOI

1 reference

21 August 2017

1 reference