A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function (Q37492337)

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1 January 2020

title

A naturally occurring variation in the proline-rich region does not attenuate human immunodeficiency virus type 1 nef function (English)

1 reference

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naturally occurring variation

1 January 2020

main subject

1 reference

Elke Rücker

1

1 reference

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1 January 2020

Jan Münch

2

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1 January 2020

Matthias Brenner

4

1 reference

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1 January 2020

Jutta Eisemann

5

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1 January 2020

Leonid Margolis

6

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1 January 2020

language of work or name

English

0 references

publication date

1 September 2004

1 reference

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1 January 2020

number of pages

5

1 reference

based on heuristic

inferred from page(s)

published in

Journal of Virology

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1 January 2020

volume

78

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1 January 2020

issue

18

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1 January 2020

page(s)

10197-10201

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Down-modulation of mature major histocompatibility complex class II and up-regulation of invariant chain cell surface expression are well-conserved functions of human and simian immunodeficiency virus nef alleles.

1 January 2020

cites work

1 reference

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Nef-mediated downregulation of CD4 enhances human immunodeficiency virus type 1 replication in primary T lymphocytes

23 August 2017

1 reference

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HIV-1 Nef impairs MHC class II antigen presentation and surface expression

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514962

CD4 down-modulation by human immunodeficiency virus type 1 Nef correlates with the efficiency of viral replication and with CD4(+) T-cell depletion in human lymphoid tissue ex vivo

23 August 2017

1 reference

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Mechanism for down-regulation of CD28 by Nef.

23 August 2017

1 reference

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HIV and SIV Nef modulate signal transduction and protein sorting in T cells

23 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514962

Identification of the Nef-associated kinase as p21-activated kinase 2

23 August 2017

1 reference

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Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner

23 August 2017

1 reference

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Sequence variations in human immunodeficiency virus type 1 Nef are associated with different stages of disease

23 August 2017

1 reference

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Nef enhances human immunodeficiency virus replication and responsiveness to interleukin-2 in human lymphoid tissue ex vivo.

23 August 2017

1 reference

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The SH3 domain-binding surface and an acidic motif in HIV-1 Nef regulate trafficking of class I MHC complexes

23 August 2017

1 reference

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Endocytosis of major histocompatibility complex class I molecules is induced by the HIV–1 Nef protein

23 August 2017

1 reference

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The human immunodeficiency virus-1 nef gene product: a positive factor for viral infection and replication in primary lymphocytes and macrophages

23 August 2017

1 reference

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Optimal infectivity in vitro of human immunodeficiency virus type 1 requires an intact nef gene.

23 August 2017

1 reference

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Downregulation of cell-surface CD4 expression by simian immunodeficiency virus Nef prevents viral super infection

23 August 2017

1 reference

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Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4

23 August 2017

1 reference

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Production of acquired immunodeficiency syndrome-associated retrovirus in human and nonhuman cells transfected with an infectious molecular clone

23 August 2017

1 reference

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Serine phosphorylation-independent downregulation of cell-surface CD4 by nef

23 August 2017

1 reference

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Disrupting surfaces of nef required for downregulation of CD4 and for enhancement of virion infectivity attenuates simian immunodeficiency virus replication in vivo

23 August 2017

1 reference

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Modulation of different human immunodeficiency virus type 1 Nef functions during progression to AIDS

6 September 2017

1 reference

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Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity

14 September 2017

1 reference

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Nef enhances human immunodeficiency virus type 1 infectivity and replication independently of viral coreceptor tropism

14 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514962

A natural variability in the proline-rich motif of Nef modulates HIV-1 replication in primary T cells.

14 September 2017

1 reference

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Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein

28 September 2017

1 reference

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The growth advantage conferred by HIV-1 nef is determined at the level of viral DNA formation and is independent of CD4 downregulation.

28 September 2017

1 reference

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The importance of nef in the induction of human immunodeficiency virus type 1 replication from primary quiescent CD4 lymphocytes.

28 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514962

HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

26 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514962

Enhanced CD4 down-modulation by late stage HIV-1 nef alleles is associated with increased Env incorporation and viral replication

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=514962

10.1128/JVI.78.18.10197-10201.2004

2 September 2018

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:15331753%20AND%20SRC:MED&resulttype=core&format=json

1 January 2020

1 reference

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1 January 2020

PubMed publication ID

15331753

1 reference