Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis. (Q37369546)

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27 January 2020

title

Probing the folding transition state structure of the villin headpiece subdomain via side chain and backbone mutagenesis (English)

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27 January 2020

author name string

Michelle R Bunagan

series ordinal

1

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27 January 2020

Feng Gai

series ordinal

4

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27 January 2020

language of work or name

English

0 references

publication date

1 June 2009

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Journal of the American Chemical Society

27 January 2020

published in

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27 January 2020

volume

131

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27 January 2020

issue

21

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27 January 2020

page(s)

7470-7476

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Chemical, physical, and theoretical kinetics of an ultrafast folding protein

27 January 2020

cites work

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Toward quantification of protein backbone-backbone hydrogen bonding energies: An energetic analysis of an amide-to-ester mutation in an alpha-helix within a protein

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Estimating free-energy barrier heights for an ultrafast folding protein from calorimetric and kinetic data

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Universality and diversity of folding mechanics for three-helix bundle proteins

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Implicit modeling of nonpolar solvation for simulating protein folding and conformational transitions.

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Heterogeneity even at the speed limit of folding: large-scale molecular dynamics study of a fast-folding variant of the villin headpiece

6 September 2017

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6 September 2017

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6 September 2017

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The unfolded state of the villin headpiece helical subdomain: computational studies of the role of locally stabilized structure

6 September 2017

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Identification of the PXW sequence as a structural gatekeeper of the headpiece C-terminal subdomain fold

6 September 2017

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Sub-microsecond protein folding

6 September 2017

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Backbone-Backbone H-Bonds Make Context-Dependent Contributions to Protein Folding Kinetics and Thermodynamics: Lessons from Amide-to-Ester Mutations.

6 September 2017

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Configurations of Polypeptide Chains With Favored Orientations Around Single Bonds: Two New Pleated Sheets

6 September 2017

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Understanding the mechanism of beta-hairpin folding via phi-value analysis

6 September 2017

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Conserved thermodynamic contributions of backbone hydrogen bonds in a protein fold

6 September 2017

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Effect of modulating unfolded state structure on the folding kinetics of the villin headpiece subdomain

6 September 2017

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Phi values in protein-folding kinetics have energetic and structural components.

6 September 2017

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High-resolution x-ray crystal structures of the villin headpiece subdomain, an ultrafast folding protein

6 September 2017

1 reference

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Determination of ultrafast protein folding rates from loop formation dynamics

6 September 2017

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Probing site-specific conformational distributions in protein folding with solid-state NMR

6 September 2017

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Understanding the key factors that control the rate of beta-hairpin folding

6 September 2017

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Context-dependent contributions of backbone hydrogen bonding to beta-sheet folding energetics

6 September 2017

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Solution structures of the C-terminal headpiece subdomains of human villin and advillin, evaluation of headpiece F-actin-binding requirements

6 September 2017

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The structure of proteins; two hydrogen-bonded helical configurations of the polypeptide chain

6 September 2017

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Ultrafast folding of alpha3D: a de novo designed three-helix bundle protein

6 September 2017

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Experimental tests of villin subdomain folding simulations

6 September 2017

1 reference

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What vibrations tell us about proteins.

6 September 2017

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The complete folding pathway of a protein from nanoseconds to microseconds

6 September 2017

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In search of the energetic role of peptide hydrogen bonds

6 September 2017

1 reference

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The role of aromatic residues in the hydrophobic core of the villin headpiece subdomain

6 September 2017

1 reference

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The early stage of folding of villin headpiece subdomain observed in a 200-nanosecond fully solvated molecular dynamics simulation

6 September 2017

1 reference

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Optimization of rates of protein folding: the nucleation-condensation mechanism and its implications

6 September 2017

1 reference

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Mapping the transition state and pathway of protein folding by protein engineering

6 September 2017

1 reference

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Dominant forces in protein folding

6 September 2017

1 reference

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Large-scale context in protein folding: villin headpiece

6 September 2017

1 reference

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Specific intermediates in the folding reactions of small proteins and the mechanism of protein folding

14 September 2017

1 reference

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Two-stage folding of HP-35 from ab initio simulations

14 September 2017

1 reference

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Study of the Villin headpiece folding dynamics by combining coarse-grained Monte Carlo evolution and all-atom molecular dynamics.

26 June 2018

1 reference

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A one-dimensional free energy surface does not account for two-probe folding kinetics of protein alpha(3)D.

26 June 2018

1 reference

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Predicting the effect of a point mutation on a protein fold: the villin and advillin headpieces and their Pro62Ala mutants.

2 September 2018

1 reference

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The role of the turn in beta-hairpin formation during WW domain folding

2 September 2018

1 reference

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Global optimization and folding pathways of selected alpha-helical proteins.

2 September 2018

1 reference

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Folding of the villin headpiece subdomain from random structures. Analysis of the charge distribution as a function of pH.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754817

Peptide models provide evidence for significant structure in the denatured state of a rapidly folding protein: the villin headpiece subdomain

2 September 2018

1 reference

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Parallel tempering simulations of HP-36.

2 September 2018

1 reference

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Probing backbone hydrogen bonds in the hydrophobic core of GCN4.

2 September 2018

1 reference

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Application of the diffusion-collision model to the folding of three-helix bundle proteins.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754817

An experimental approach to evaluating the role of backbone interactions in proteins using unnatural amino acid mutagenesis.

2 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2754817

NMR Characterization of a Peptide Model Provides Evidence for Significant Structure in the Unfolded State of the Villin Headpiece Helical Subdomain†

2 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Understanding the folding mechanism of an alpha-helical hairpin

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Dynamic NMR Line-Shape Analysis Demonstrates that the Villin Headpiece Subdomain Folds on the Microsecond Time Scale

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

A thermostable 35-residue subdomain within villin headpiece

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Residue Specific Resolution of Protein Folding Dynamics Using Isotope-Edited Infrared Temperature Jump Spectroscopy†

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Coupling between hydration layer dynamics and unfolding kinetics of HP-36

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Ab initio folding of helix bundle proteins using molecular dynamics simulations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Direct analysis of backbone-backbone hydrogen bond formation in protein folding transition states

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Infrared study of the effect of hydration on the amide I band and aggregation properties of helical peptides

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Free-Energy Landscape of the Villin Headpiece in an All-Atom Force Field

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Toward assessing the position-dependent contributions of backbone hydrogen bonding to beta-sheet folding thermodynamics employing amide-to-ester perturbations

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Nanosecond folding dynamics of a three-stranded beta-sheet

1 reference

https://pubmed.ncbi.nlm.nih.gov/19425552

12 December 2020

Identifiers

DOI

10.1021/JA901860F

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19425552%20AND%20SRC:MED&resulttype=core&format=json

27 January 2020

1 reference

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27 January 2020

PubMed publication ID

19425552

1 reference