Roles of TGFbeta in metastasis (Q37339711)

19 August 2017

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title

Roles of TGFbeta in metastasis (English)

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19 August 2017

David Padua

1

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19 August 2017

Joan Massagué

series ordinal

2

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19 August 2017

publication date

1 January 2009

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19 August 2017

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19 August 2017

volume

19

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19 August 2017

issue

1

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19 August 2017

page(s)

89-102

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19 August 2017

cites work

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7 January 2021

The pathogenesis of cancer metastasis: the 'seed and soil' hypothesis revisited

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Cancer metastasis: building a framework

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Genetic determinants of cancer metastasis

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Stromal fibroblasts in cancer initiation and progression

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Fibroblasts in cancer

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Tumour-educated macrophages promote tumour progression and metastasis

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Migratory neighbors and distant invaders: tumor-associated niche cells

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7 January 2021

Alterations in components of the TGF-beta superfamily signaling pathways in human cancer

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7 January 2021

Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability

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7 January 2021

Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

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7 January 2021

Transforming growth factor-beta1 level correlates with angiogenesis, tumor progression, and prognosis in patients with nonsmall cell lung carcinoma

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7 January 2021

The expression of transforming growth factor-beta1 is significantly correlated with the expression of vascular endothelial growth factor and poor prognosis of patients with advanced gastric carcinoma.

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7 January 2021

High levels of transforming growth factor beta 1 in patients with colorectal cancer: association with disease progression

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7 January 2021

Transforming growth factor beta1 is associated with angiogenesis, metastasis, and poor clinical outcome in prostate cancer

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7 January 2021

Requirement for activin A and transforming growth factor--beta 1 pro-regions in homodimer assembly.

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7 January 2021

Regulation of bone morphogenetic protein activity by pro domains and proprotein convertases.

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7 January 2021

Processing of transforming growth factor beta 1 precursor by human furin convertase

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7 January 2021

Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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7 January 2021

Mechanism of activation of the TGF-beta receptor

1 reference

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7 January 2021

Crystal structure of the cytoplasmic domain of the type I TGF beta receptor in complex with FKBP12

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7 January 2021

The TGF beta receptor activation process: an inhibitor- to substrate-binding switch

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7 January 2021

Smad transcription factors

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7 January 2021

Integrating patterning signals: Wnt/GSK3 regulates the duration of the BMP/Smad1 signal

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7 January 2021

Opposing BMP and EGF signalling pathways converge on the TGF-beta family mediator Smad1

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7 January 2021

Balancing BMP Signaling through Integrated Inputs into the Smad1 Linker

1 reference

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7 January 2021

SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

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7 January 2021

A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells.

1 reference

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7 January 2021

Nucleocytoplasmic shuttling of signal transducers.

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7 January 2021

Specificity and versatility in tgf-beta signaling through Smads

1 reference

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7 January 2021

C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells

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7 January 2021

Synexpression groups in eukaryotes

1 reference

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7 January 2021

Genome-wide identification of Smad/Foxh1 targets reveals a role for Foxh1 in retinoic acid regulation and forebrain development

1 reference

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7 January 2021

Effect of conditional knockout of the type II TGF-beta receptor gene in mammary epithelia on mammary gland development and polyomavirus middle T antigen induced tumor formation and metastasis

1 reference

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7 January 2021

Loss of TGFbeta signaling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia

1 reference

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7 January 2021

Aggressive pancreatic ductal adenocarcinoma in mice caused by pancreas-specific blockade of transforming growth factor-beta signaling in cooperation with active Kras expression

1 reference

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7 January 2021

Loss of transforming growth factor-beta type II receptor promotes metastatic head-and-neck squamous cell carcinoma

1 reference

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7 January 2021

Transforming growth factor beta receptor type II inactivation induces the malignant transformation of intestinal neoplasms initiated by Apc mutation.

1 reference

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7 January 2021

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1 reference

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7 January 2021

Transforming growth factor beta receptor type II inactivation promotes the establishment and progression of colon cancer

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7 January 2021

Increased Malignancy of Neu-Induced Mammary Tumors Overexpressing Active Transforming Growth Factor β1

1 reference

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7 January 2021

Transforming growth factor beta signaling impairs Neu-induced mammary tumorigenesis while promoting pulmonary metastasis

1 reference

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7 January 2021

Focus on pancreas cancer

1 reference

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7 January 2021

Comparative lesion sequencing provides insights into tumor evolution

1 reference

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7 January 2021

Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism

1 reference

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7 January 2021

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest

1 reference

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7 January 2021

Transforming growth factor beta-induced cell cycle arrest of human hematopoietic cells requires p57KIP2 up-regulation.

1 reference

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7 January 2021

E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression

1 reference

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7 January 2021

Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

The logic of TGFbeta signaling.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Myc suppression of the p21 Cip1 Cdk inhibitor influences the outcome of the p53 response to DNA damage

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGF-beta induces apoptosis through Smad-mediated expression of DAP-kinase

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Activin/TGF-beta induce apoptosis through Smad-dependent expression of the lipid phosphatase SHIP.

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGF-beta-induced apoptosis is mediated by the adapter protein Daxx that facilitates JNK activation

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Mechanisms of TGF-beta-mediated apoptosis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Limited overlapping roles of P15(INK4b) and P18(INK4c) cell cycle inhibitors in proliferation and tumorigenesis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor beta growth arrest program

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Overexpression of C/EBPbeta-LIP, a naturally occurring, dominant-negative transcription factor, in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGF-beta directly targets cytotoxic T cell functions during tumor evasion of immune surveillance

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Anti-transforming growth factor (TGF)-beta antibodies inhibit breast cancer cell tumorigenicity and increase mouse spleen natural killer cell activity. Implications for a possible role of tumor cell/host TGF-beta interactions in human breast cancer

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Regulation of the proinflammatory effects of Fas ligand (CD95L).

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Immunoregulatory role of transforming growth factor beta (TGF-beta) in development of killer cells: comparison of active and latent TGF-beta 1

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

A multigenic program mediating breast cancer metastasis to bone

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Synergistic cooperation between hypoxia and transforming growth factor-beta pathways on human vascular endothelial growth factor gene expression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGF-beta signaling in tumor suppression and cancer progression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Abnormal angiogenesis but intact hematopoietic potential in TGF-beta type I receptor-deficient mice

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGF-beta receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Epithelial-mesenchymal transitions in tumour progression

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Differentiation plasticity regulated by TGF-beta family proteins in development and disease

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

The epithelial-mesenchymal transition generates cells with properties of stem cells

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Molecular definition of breast tumor heterogeneity

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

1 reference

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7 January 2021

Stable Overexpression of Smad7 in Human Melanoma Cells Impairs Bone Metastasis

1 reference

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7 January 2021

TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases development

1 reference

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7 January 2021

Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysis

1 reference

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7 January 2021

Molecular biology of bone metastasis

1 reference

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7 January 2021

Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects

1 reference

https://api.crossref.org/works/10.1038%2FCR.2008.316

7 January 2021

Inhibition of TGF-beta with neutralizing antibodies prevents radiation-induced acceleration of metastatic cancer progression.

1 reference

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7 January 2021

An anti-transforming growth factor beta antibody suppresses metastasis via cooperative effects on multiple cell compartments.

1 reference

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7 January 2021

Smad-binding defective mutant of transforming growth factor beta type I receptor enhances tumorigenesis but suppresses metastasis of breast cancer cell lines

1 reference

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7 January 2021

Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene

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7 January 2021

Loss of TGF-beta type II receptor in fibroblasts promotes mammary carcinoma growth and invasion through upregulation of TGF-alpha-, MSP- and HGF-mediated signaling networks

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7 January 2021

Transforming growth factor-beta regulates mammary carcinoma cell survival and interaction with the adjacent microenvironment

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7 January 2021

Enhanced hepatocyte growth factor signaling by type II transforming growth factor-beta receptor knockout fibroblasts promotes mammary tumorigenesis.

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7 January 2021

Abrogation of TGF beta signaling in mammary carcinomas recruits Gr-1+CD11b+ myeloid cells that promote metastasis

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7 January 2021

The loss of TGF-beta signaling promotes prostate cancer metastasis

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7 January 2021

Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer

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7 January 2021

https://api.crossref.org/works/10.1038%2FCR.2008.316

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7 January 2021

Prognostic significance of transforming growth factor beta receptor II in estrogen receptor-negative breast cancer patients

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7 January 2021

TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4

1 reference

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7 January 2021

Development of TGF-beta signalling inhibitors for cancer therapy

1 reference

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7 January 2021

Genes that mediate breast cancer metastasis to lung

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7 January 2021

Identifiers

DOI

10.1038/CR.2008.316

1 reference

Dimensions Publication ID

19 August 2017

1010582724

0 references

1 reference