Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. (Q37147592)

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scientific article published on August 2016

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English	Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.	scientific article published on August 2016

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20 March 2020

Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex (English)

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20 March 2020

nucleus accumbens

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Leandro F Vendruscolo

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20 March 2020

Giuseppe Giannotti

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20 March 2020

Fabio Fumagalli

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Judith R. Homberg

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George F Koob

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Michel M M Verheij

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20 March 2020

Lucia Caffino

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Candice Contet

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1 August 2016

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20 March 2020

Journal of Neuroscience

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20 March 2020

8149-8159

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20 March 2020

The brain reward circuitry in mood disorders

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Regulation of BDNF expression by cocaine.

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6 September 2017

Increased brain-derived neurotrophic factor (BDNF) expression in the ventral tegmental area during cocaine abstinence is associated with increased histone acetylation at BDNF exon I-containing promoters

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Identification of a low-molecular weight TrkB antagonist with anxiolytic and antidepressant activity in mice

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6 September 2017

The suppressive effect of an intra-prefrontal cortical infusion of BDNF on cocaine-seeking is Trk receptor and extracellular signal-regulated protein kinase mitogen-activated protein kinase dependent

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Cell type-specific loss of BDNF signaling mimics optogenetic control of cocaine reward

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Elevated BDNF after cocaine withdrawal facilitates LTP in medial prefrontal cortex by suppressing GABA inhibition

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6 September 2017

Cocaine-induced chromatin remodeling increases brain-derived neurotrophic factor transcription in the rat medial prefrontal cortex, which alters the reinforcing efficacy of cocaine

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Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice

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Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats

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Brain-derived neurotrophic factor and cocaine addiction

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Neurocircuitry of addiction

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A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions

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6 September 2017

Role of ventral tegmental area glial cell line-derived neurotrophic factor in incubation of cocaine craving.

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6 September 2017

A single intra-PFC infusion of BDNF prevents cocaine-induced alterations in extracellular glutamate within the nucleus accumbens

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6 September 2017

Rats that differentially respond to cocaine differ in their dopaminergic storage capacity of the nucleus accumbens

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Brain-derived neurotrophic factor and its intracellular signaling pathways in cocaine addiction

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Essential role of BDNF in the mesolimbic dopamine pathway in social defeat stress

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BDNF controls dopamine D3 receptor expression and triggers behavioural sensitization

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3 September 2018

Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbens

1 reference

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3 September 2018

Repeated stress prevents cocaine-induced activation of BDNF signaling in rat prefrontal cortex

1 reference

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3 September 2018

A BDNF infusion into the medial prefrontal cortex suppresses cocaine seeking in rats

1 reference

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Effects of dose and session duration on cocaine self-administration in rats

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BDNF-dependent synaptic sensitization in midbrain dopamine neurons after cocaine withdrawal

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Alterations in BDNF and trkB mRNAs following acute or sensitizing cocaine treatments and withdrawal

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A single cocaine exposure increases BDNF and D3 receptor expression: implications for drug-conditioning.

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3 September 2018

A single infusion of brain-derived neurotrophic factor into the ventral tegmental area induces long-lasting potentiation of cocaine seeking after withdrawal.

1 reference

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Progressive ratio as a measure of reward strength.

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Signalling pathways involved in the short-term potentiation of dopamine release by BDNF.

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3 September 2018

Time-dependent increases in brain-derived neurotrophic factor protein levels within the mesolimbic dopamine system after withdrawal from cocaine: implications for incubation of cocaine craving.

1 reference

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3 September 2018

Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor.

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3 September 2018

Brain-derived neurotrophic factor and neurotrophin-3 activate striatal dopamine and serotonin metabolism and related behaviors: interactions with amphetamine

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3 September 2018

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10.1523/JNEUROSCI.2711-14.2016

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20 March 2020

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20 March 2020

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20 March 2020

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