Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? (Q37120213)

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4 January 2020

review article

1 reference

title

Targeting the Bcl-2-regulated apoptosis pathway by BH3 mimetics: a breakthrough in anticancer therapy? (English)

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4 January 2020

0 references

1

1 reference

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4 January 2020

Francesca Grespi

series ordinal

2

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4 January 2020

author name string

F Baumgartner

series ordinal

3

1 reference

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4 January 2020

A Villunger

series ordinal

4

1 reference

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4 January 2020

publication date

28 March 2008

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Cell Death & Differentiation

4 January 2020

published in

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4 January 2020

volume

15

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4 January 2020

issue

6

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4 January 2020

page(s)

977-987

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The BCL-2 protein family: opposing activities that mediate cell death

4 January 2020

cites work

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Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

14 September 2017

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Chronic lymphocytic leukemia requires BCL2 to sequester prodeath BIM, explaining sensitivity to BCL2 antagonist ABT-737.

14 September 2017

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'Seed' analysis of off-target siRNAs reveals an essential role of Mcl-1 in resistance to the small-molecule Bcl-2/Bcl-XL inhibitor ABT-737.

14 September 2017

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A stapled BID BH3 helix directly binds and activates BAX

14 September 2017

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14 September 2017

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Bim and Bad mediate imatinib-induced killing of Bcr/Abl+ leukemic cells, and resistance due to their loss is overcome by a BH3 mimetic.

14 September 2017

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14 September 2017

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14 September 2017

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BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly

14 September 2017

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Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function

14 September 2017

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14 September 2017

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14 September 2017

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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14 September 2017

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Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation

14 September 2017

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The BH3 mimetic ABT-737 targets selective Bcl-2 proteins and efficiently induces apoptosis via Bak/Bax if Mcl-1 is neutralized.

27 June 2018

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CD95L pro-drug: a novel Swiss Army Knife in cancer therapy?

27 June 2018

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Bcl-2 family proteins are essential for platelet survival.

3 September 2018

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A novel Bcl-2/Bcl-X(L)/Bcl-w inhibitor ABT-737 as therapy in multiple myeloma.

3 September 2018

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A phase II, pharmacokinetic, and biological correlative study of oblimersen sodium and docetaxel in patients with hormone-refractory prostate cancer

3 September 2018

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Phase I study of G3139, a bcl-2 antisense oligonucleotide, combined with carboplatin and etoposide in patients with small-cell lung cancer

3 September 2018

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HA14-1 selectively induces apoptosis in Bcl-2-overexpressing leukemia/lymphoma cells, and enhances cytarabine-induced cell death

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563920

Identification of chelerythrine as an inhibitor of BclXL function

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563920

Development of a potent Bcl-x(L) antagonist based on alpha-helix mimicry

3 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4563920

The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of Bak

3 September 2018

1 reference

Crossref

https://api.crossref.org/works/10.1038%2FCDD.2008.37

Bcl-2 antisense therapy in multiple myeloma

21 January 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/18369371

12 December 2020

A Phase II study of Bcl-2 antisense (oblimersen sodium) combined with gemtuzumab ozogamicin in older patients with acute myeloid leukemia in first relapse

1 reference

https://pubmed.ncbi.nlm.nih.gov/18369371

12 December 2020

GOSSYPOL--A TOXIC SUBSTANCE IN COTTONSEED. A PRELIMINARY NOTE

1 reference

https://pubmed.ncbi.nlm.nih.gov/18369371

12 December 2020

Analysis of ribosyl-modified, mixed backbone analogs of a bcl-2/bcl-xL antisense oligonucleotide

1 reference

https://pubmed.ncbi.nlm.nih.gov/18369371

12 December 2020

Identifiers

DOI

10.1038/CDD.2008.37

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18369371%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:18369371%20AND%20SRC:MED&resulttype=core&format=json

4 January 2020

PubMed publication ID

18369371

1 reference