Conformational complexity of G-protein-coupled receptors (Q36880905)

16 August 2017

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title

Conformational complexity of G-protein-coupled receptors (English)

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G protein-coupled receptor

16 August 2017

main subject

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G protein-coupled receptor signaling in absence of ligand

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Gene Ontology release 2020-05-02

1

Brian K Kobilka

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16 August 2017

Xavier Deupi

2

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publication date

13 July 2007

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Trends in Pharmacological Sciences

16 August 2017

published in

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16 August 2017

volume

28

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16 August 2017

issue

8

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16 August 2017

page(s)

397-406

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Functionally different agonists induce distinct conformations in the G protein coupling domain of the beta 2 adrenergic receptor

16 August 2017

cites work

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Agonist-induced conformational changes in the G-protein-coupling domain of the beta 2 adrenergic receptor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

The Role of a Conserved Region of the Second Intracellular Loop in AT1 Angiotensin Receptor Activation and Signaling

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

The neurokinin A receptor activates calcium and cAMP responses through distinct conformational states

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Requirement of rigid-body motion of transmembrane helices for light activation of rhodopsin

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Transduction of receptor signals by beta-arrestins

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11 October 2022

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Chimeric alpha 2-,beta 2-adrenergic receptors: delineation of domains involved in effector coupling and ligand binding specificity

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11 October 2022

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Ligand-selective receptor conformations revisited: the promise and the problem

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Beta-arrestin-mediated activation of MAPK by inverse agonists reveals distinct active conformations for G protein-coupled receptors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

The activation process of the alpha1B-adrenergic receptor: potential role of protonation and hydrophobicity of a highly conserved aspartate

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Transmembrane regions V and VI of the human luteinizing hormone receptor are required for constitutive activation by a mutation in the third intracellular loop

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Lessons from constitutively active mutants of G protein-coupled receptors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Structure and function in rhodopsin: rhodopsin mutants with a neutral amino acid at E134 have a partially activated conformation in the dark state

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Probing the beta2 adrenoceptor binding site with catechol reveals differences in binding and activation by agonists and partial agonists

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Structural instability of a constitutively active G protein-coupled receptor. Agonist-independent activation due to conformational flexibility

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Mutation of Asn111 in the third transmembrane domain of the AT1A angiotensin II receptor induces its constitutive activation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

The conformational change responsible for AT1 receptor activation is dependent upon two juxtaposed asparagine residues on transmembrane helices III and VII.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Structural domains of the CB1 cannabinoid receptor that contribute to constitutive activity and G-protein sequestration.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Crystal structure of rhodopsin: A G protein-coupled receptor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Efficacy at G-protein-coupled receptors

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Generation and analysis of constitutively active and physically destabilized mutants of the human beta(1)-adrenoceptor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Coupling ligand structure to specific conformational switches in the beta2-adrenoceptor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Plasma Membrane Localization and Functional Rescue of Truncated Forms of a G Protein-coupled Receptor

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

The effect of pH on beta(2) adrenoceptor function. Evidence for protonation-dependent activation.

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

The Energy Landscapes and Motions of Proteins

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Sequential binding of agonists to the beta2 adrenoceptor. Kinetic evidence for intermediate conformational states

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

The active state of the AT1 angiotensin receptor is generated by angiotensin II induction

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Agonist binding: a multistep process

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

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11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Ligands act as pharmacological chaperones and increase the efficiency of delta opioid receptor maturation

1 reference

11 October 2022

https://opencitations.net/index/coci/api/v1/references/10.1016/J.TIPS.2007.06.003

Identifiers

DOI

10.1016/J.TIPS.2007.06.003

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16 August 2017

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