Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road (Q36844719)

16 August 2017

1 reference

title

Clinical trials of Shigella vaccines: two steps forward and one step back on a long, hard road (English)

1 reference

16 August 2017

2

Karen L Kotloff

1 reference

16 August 2017

1

Myron M Levine

1 reference

16 August 2017

4

Marcela F Pasetti

1 reference

16 August 2017

Eileen M Barry

3

1 reference

16 August 2017

Marcelo B Sztein

series ordinal

5

1 reference

16 August 2017

language of work or name

English

0 references

publication date

1 July 2007

1 reference

Nature Reviews Microbiology

16 August 2017

1 reference

16 August 2017

5

1 reference

16 August 2017

7

1 reference

16 August 2017

540-553

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O-specific [corrected] polysaccharide conjugate vaccine-induced [corrected] antibodies prevent invasion of Shigella into Caco-2 cells and may be curative

16 August 2017

1 reference

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Shigella's ways of manipulating the host intestinal innate and adaptive immune system: a tool box for survival?

29 September 2017

1 reference

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Distribution of Shigella enterotoxin genes and secreted autotransporter toxin gene among diverse species and serotypes of shigella isolated from Andaman Islands, India

29 September 2017

1 reference

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A multicentre study of Shigella diarrhoea in six Asian countries: disease burden, clinical manifestations, and microbiology

29 September 2017

1 reference

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Complete genome sequence of Shigella flexneri 5b and comparison with Shigella flexneri 2a.

29 September 2017

1 reference

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Epidemiology and genetic characterization of Shigella flexneri strains isolated from three paediatric populations in Egypt (2000-2004).

29 September 2017

1 reference

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Protection of Monkeys Against Experimental Shigellosis with Attenuated Vaccines.

29 September 2017

1 reference

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Community-based safety, immunogenicity, and transmissibility study of the Shigella sonnei WRSS1 vaccine in Israeli volunteers

29 September 2017

1 reference

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Safety and immunogenicity of an oral, inactivated, whole-cell vaccine for Shigella sonnei: preclinical studies and a Phase I trial

29 September 2017

1 reference

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Deletion in the Shigella enterotoxin genes further attenuates Shigella flexneri 2a bearing guanine auxotrophy in a phase 1 trial of CVD 1204 and CVD 1208.

29 September 2017

1 reference

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Bacterial invasion: the paradigms of enteroinvasive pathogens

29 September 2017

1 reference

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Two studies evaluating the safety and immunogenicity of a live, attenuated Shigella flexneri 2a vaccine (SC602) and excretion of vaccine organisms in North American volunteers.

29 September 2017

1 reference

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VIRULENCE OF ESCHERICHIA-SHIGELLA GENETIC HYBRIDS FOR THE GUINEA PIG

29 September 2017

1 reference

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Safety and immunogenicity of Shigella sonnei-CRM9 and Shigella flexneri type 2a-rEPAsucc conjugate vaccines in one- to four-year-old children

29 September 2017

1 reference

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Sharing Shigella: risk factors for a multicommunity outbreak of shigellosis

29 September 2017

1 reference

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Molecular cloning and characterization of genes for Shigella sonnei form I O polysaccharide: proposed biosynthetic pathway and stable expression in a live salmonella vaccine vector

29 September 2017

1 reference

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Bacillus dysentericus (sic) 1897 was the first rather than Bacillus dysenteriae 1898

29 September 2017

1 reference

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Phase I evaluation of delta virG Shigella sonnei live, attenuated, oral vaccine strain WRSS1 in healthy adults

29 September 2017

1 reference

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Safety and immunogenicity of a proteosome-Shigella flexneri 2a lipopolysaccharide vaccine administered intranasally to healthy adults

29 September 2017

1 reference

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Immunization against bacterial diseases of the intestine

29 September 2017

1 reference

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Shigella flexneri 2a strain CVD 1207, with specific deletions in virG, sen, set, and guaBA, is highly attenuated in humans

29 September 2017

1 reference

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Global burden of Shigella infections: implications for vaccine development and implementation of control strategies

29 September 2017

1 reference

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Vaccination against shigellosis with attenuated Shigella flexneri 2a strain SC602

29 September 2017

1 reference

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Strategy for cross-protection among Shigella flexneri serotypes

29 September 2017

1 reference

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Construction of a stable attenuated Shigella sonnei DeltavirG vaccine strain, WRSS1, and protective efficacy and immunogenicity in the guinea pig keratoconjunctivitis model

29 September 2017

1 reference

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Effect of shigella enterotoxin 1 (ShET1) on rabbit intestine in vitro and in vivo

29 September 2017

1 reference

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A household survey of dysentery in Burundi: implications for the current pandemic in sub-Saharan Africa

29 September 2017

1 reference

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Safety and immunogenicity of investigational Shigella conjugate vaccines in Israeli volunteers

29 September 2017

1 reference

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Lipopolysaccharide-specific antibodies in plasma and stools of children with Shigella-associated leukemoid reaction and hemolytic-uremic syndrome

29 September 2017

1 reference

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Safety, immunogenicity, and transmissibility in humans of CVD 1203, a live oral Shigella flexneri 2a vaccine candidate attenuated by deletions in aroA and virG.

29 September 2017

1 reference

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Detection of antibodies to Shigella lipopolysaccharide in urine after natural Shigella infection or vaccination

29 September 2017

1 reference

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Engineered deltaguaB-A deltavirG Shigella flexneri 2a strain CVD 1205: construction, safety, immunogenicity, and potential efficacy as a mucosal vaccine

29 September 2017

1 reference

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Local entrapment of interferon gamma in the recovery from Shigella dysenteriae type 1 infection.

29 September 2017

1 reference

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Changes in the peripheral blood T-Cell receptor V beta repertoire in vivo and in vitro during shigellosis.

29 September 2017

1 reference

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Safety and immunogenicity of the live oral auxotrophic Shigella flexneri SFL124 in adult Vietnamese volunteers

29 September 2017

1 reference

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Immune responses in Vietnamese children after a single dose of the auxotrophic, live Shigella flexneri Y vaccine strain SFL124.

29 September 2017

1 reference

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Construction and characterization of attenuated delta aroA delta virG Shigella flexneri 2a strain CVD 1203, a prototype live oral vaccine

29 September 2017

1 reference

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Persistence of local cytokine production in shigellosis in acute and convalescent stages.

29 September 2017

1 reference

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Shigella enterotoxin 1: an enterotoxin of Shigella flexneri 2a active in rabbit small intestine in vivo and in vitro

29 September 2017

1 reference

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Immunoglobulin subclass distribution and dynamics of Shigella-specific antibody responses in serum and stool samples in shigellosis

29 September 2017

1 reference

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Evaluation of the safety, immunogenicity, and efficacy in healthy adults of four doses of live oral hybrid Escherichia coli-Shigella flexneri 2a vaccine strain EcSf2a-2

29 September 2017

1 reference

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Shigella infection induces cellular activation of T and B cells and distinct species-related changes in peripheral blood lymphocyte subsets during the course of the disease

29 September 2017

1 reference

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Identification and cloning of a novel plasmid-encoded enterotoxin of enteroinvasive Escherichia coli and Shigella strains

29 September 2017

1 reference

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Unusual lipopolysaccharide antigens of a Salmonella typhi oral vaccine strain expressing the Shigella sonnei form I antigen.

29 September 2017

1 reference

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Safety and Antigenicity of Typhoid-Shigella sonnei Vaccine (Strain 5076-1C)

29 September 2017

1 reference

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Construction of a potential bivalent vaccine strain: introduction of Shigella sonnei form I antigen genes into the galE Salmonella typhi Ty21a typhoid vaccine strain

29 September 2017

1 reference

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Protection of Monkeys Against Experimental Shigellosis with a Living Attenuated Oral Polyvalent Dysentery Vaccine

29 September 2017

1 reference

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Studies on vaccination against bacillary dysentery. 6. Protection of children by oral immunization with streptomycin-dependent Shigella strains

29 September 2017

1 reference

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Serum immune response to Shigella protein antigens in rhesus monkeys and humans infected with Shigella spp

29 September 2017

1 reference

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Trial of an attenuated bovine rotavirus vaccine (RIT 4237) in Gambian infants

29 September 2017

1 reference

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Use of monoclonal antibodies to type Shigella flexneri in Bangladesh

29 September 2017

1 reference

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Shigella flexneri O-antigen epitopes: chemical and immunochemical analyses reveal that epitopes of type III and group 6 antigens are identical

29 September 2017

1 reference

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Prospective study of systemic and mucosal immune responses in dysenteric patients to specific Shigella invasion plasmid antigens and lipopolysaccharides.

29 September 2017

1 reference

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Molecular analysis of variant plasmid forms of a bivalent Salmonella typhi-Shigella sonnei vaccine strain

29 September 2017

1 reference

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Epidemiologic patterns of acute diarrhea and endemic Shigella infections in children in a poor periurban setting in Santiago, Chile

29 September 2017

1 reference

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Small-animal model to measure efficacy and immunogenicity of Shigella vaccine strains

29 September 2017

1 reference

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Protective ribosomal preparation from Shigella sonnei as a parenteral candidate vaccine

29 September 2017

1 reference

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The lipopolysaccharide of Shigella bacteria as a virulence factor

29 September 2017

1 reference

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Prospective study of the association between serum antibodies to lipopolysaccharide O antigen and the attack rate of shigellosis

29 September 2017

1 reference

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Specific immunoglobulin A-secreting cells in peripheral blood of humans following oral immunization with a bivalent Salmonella typhi-Shigella sonnei vaccine or infection by pathogenic S. sonnei

29 September 2017

1 reference

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Diarrheal disease during Operation Desert Shield

29 September 2017

1 reference

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Safety, immunogenicity, and efficacy in monkeys and humans of invasive Escherichia coli K-12 hybrid vaccine candidates expressing Shigella flexneri 2a somatic antigen.

29 September 2017

1 reference

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Presence of specific immunoglobulin A-secreting cells in peripheral blood after natural infection with Shigella sonnei

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Hypothesis for vaccine development: protective immunity to enteric diseases caused by nontyphoidal salmonellae and shigellae may be conferred by serum IgG antibodies to the O-specific polysaccharide of their lipopolysaccharides

29 September 2017

1 reference

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Safety and immunogenicity of single-dose live oral cholera vaccine CVD 103-HgR in 5-9-year-old Indonesian children

29 September 2017

1 reference

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Fluid and electrolyte transport in rhesus monkeys challenged intracecally with Shigella flexneri 2a.

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Studies with a New Generation of Oral Attenuated Shigella Vaccine: Escherichia coli Bearing Surface Antigens of Shigella flexneri

29 September 2017

1 reference

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Production of IFN-gamma and IL-10 to Shigella invasins by mononuclear cells from volunteers orally inoculated with a Shiga toxin-deleted Shigella dysenteriae type 1 strain

29 September 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Double-blind vaccine-controlled randomised efficacy trial of an investigational Shigella sonnei conjugate vaccine in young adults.

27 June 2018

1 reference

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A modified Shigella volunteer challenge model in which the inoculum is administered with bicarbonate buffer: clinical experience and implications for Shigella infectivity.

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Epidemic Shiga bacillus dysentery in Central Africa

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Studies on vaccination against bacillary dysentery. 2. Safety tests and reactogenicity studies on a live dysentery vaccine intended for use in field trials

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Studies on vaccination against bacillary dysentery. 1. Immunization of mice against experimental Shigella infection

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Failure of parenteral vaccines to protect monkeys against experimental shigellosis

27 June 2018

1 reference

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Epidemic Shiga Bacillus Dysentery in Central America. I. Etiologic Investigations in Guatemala, 1969

27 June 2018

1 reference

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Pathogenesis of Shigella dysenteriae 1 (Shiga) Dysentery

27 June 2018

1 reference

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Live oral Shigella vaccine: vaccination schedule and the effect of booster dose.

27 June 2018

1 reference

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Shigellosis in custodial institutions. 3. Prospective clinical and bacteriologic surveillance of children vaccinated with oral attenuated shigella vaccines.

27 June 2018

1 reference

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Freeze-drying of live oral streptomycin-dependent mutant Shigella vaccines: survival of streptomycin-dependent Shigella flexneri 2a after freeze-drying.

27 June 2018

1 reference

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Shigellosis in custodial institutions. II. Clinical, immunologic and bacteriologic response of institutionalized children to oral attenuated shigella vaccines

27 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Immunity in Shigellosis. I. Response of Man to Attenuated Strains of Shigella

27 June 2018

1 reference

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Inoculum size in shigellosis and implications for expected mode of transmission

27 June 2018

1 reference

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Prevention of shigellosis by a Salmonella typhi-Shigella sonnei bivalent vaccine.

27 June 2018

1 reference

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Studies in volunteers to evaluate candidate Shigella vaccines: further experience with a bivalent Salmonella typhi-Shigella sonnei vaccine and protection conferred by previous Shigella sonnei disease.

27 June 2018

1 reference

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Cell wall structures which may be important for successful immunization with Salmonella-Shigella hybrid vaccines.

27 June 2018

1 reference

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Virulence phenotype and genetic characteristics of the T32-ISTRATI Shigella flexneri 2a vaccine strain

27 June 2018

1 reference

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Efficacy of bovine milk immunoglobulin concentrate in preventing illness after Shigella flexneri challenge

27 June 2018

1 reference

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Genotypic and phenotypic characterization of an aroD deletion-attenuated Escherichia coli K12-Shigella flexneri hybrid vaccine expressing S. flexneri 2a somatic antigen

27 June 2018

1 reference

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An Outbreak of Dysentery Caused by Shigella dysenteriae Type 1 on a Coral Island in the Bay of Bengal

27 June 2018

1 reference

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Pathophysiology of Shigella diarrhea in the rhesus monkey: intestinal transport, morphological, and bacteriological studies

27 June 2018

1 reference

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Structural and genetic evidence that the Escherichia coli O148 O antigen is the precursor of the Shigella dysenteriae type 1 O antigen and identification of a glucosyltransferase gene

27 June 2018

1 reference

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Characterization of functional oligosaccharide mimics of the Shigella flexneri serotype 2a O-antigen: implications for the development of a chemically defined glycoconjugate vaccine

5 September 2018

1 reference

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Development and evaluation of a Shigella flexneri 2a and S. sonnei bivalent invasin complex (Invaplex) vaccine

5 September 2018

1 reference

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Surveillance for antimicrobial resistance profiles among Shigella species isolated from a semirural community in the northern administrative area of santiago, chile.

5 September 2018

1 reference

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Optimization of virulence functions through glucosylation of Shigella LPS.

5 September 2018

1 reference

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Prevalence of the sat, set and sen genes among diverse serotypes of Shigella flexneri strains isolated from patients with acute diarrhoea

5 September 2018

1 reference

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Epidemiology of sporadic bloody diarrhea in rural Western Kenya

5 September 2018

1 reference

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Calibrated serological techniques demonstrate significant different serum response rates to an oral killed cholera vaccine between Swedish and Nicaraguan children.

5 September 2018

1 reference

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Prevalence of the genes for shigella enterotoxins 1 and 2 among clinical isolates of shigella in Israel.

5 September 2018

1 reference

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Two msbB genes encoding maximal acylation of lipid A are required for invasive Shigella flexneri to mediate inflammatory rupture and destruction of the intestinal epithelium

5 September 2018

1 reference

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Population-based study of the incidence of Shigella diarrhea and causative serotypes in Santiago, Chile

5 September 2018

1 reference

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Assessing the cause of in-patients pediatric diarrheal deaths: an analysis of hospital records.

5 September 2018

1 reference

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Prevalence of Shigella Enterotoxin 1 among Shigella Clinical Isolates of Diverse Serotypes

5 September 2018

1 reference

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Shigellosis in Mozambique: the 1993 outbreak rehabilitation--a follow-up study

5 September 2018

1 reference

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Studies on vaccination against bacillary dysentery. 4. Oral immunization with live monotypic and combined vaccines

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Studies on vaccination against bacillary dysentery. 3. Effective oral immunization against Shigella flexneri 2a in a field trial

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Delayed and reduced adaptive humoral immune responses in children with shigellosis compared with in adults

5 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Cytokine secretion in acute shigellosis is correlated to disease activity and directed more to stool than to plasma

20 October 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=3771495

Perinatal outcome following third-trimester exposure to paroxetine: an alternative interpretation

4 December 2018

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1662

The response of man to virulent Shigella flexneri 2a

31 March 2020

1 reference

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Effect of prior infection with virulent Shigella flexneri 2a on the resistance of monkeys to subsequent infection with Shigella sonnei

31 March 2020

1 reference

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Immunity in Shigellosis. II. Protection Induced by Oral Live Vaccine or Primary Infection

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1662

Age-Specific Prevalence of Serum Antibodies to the Invasion Plasmid and Lipopolysaccharide Antigens of Shigella Species in Chilean and North American Populations

31 March 2020

1 reference

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Dissociation between cytokine mRNA expression and protein production in shigellosis

31 March 2020

2 references

https://api.crossref.org/works/10.1038%2FNRMICRO1662

31 March 2020

https://pubmed.ncbi.nlm.nih.gov/17558427

12 December 2020

Shigellosis in custodial institutions. V. Effect of intervention with streptomycin-dependent Shigella sonnei vaccine in an institution with endemic disease

1 reference

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Safety and immunogenicity study of the auxotrophic Shigella flexneri 2a vaccine SFL1070 with a deleted aroD gene in adult Swedish volunteers

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1662

Serum antibodies to lipopolysaccharide and natural immunity to shigellosis in an Israeli military population

31 March 2020

1 reference

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Safety and immunogenicity of Shigella sonnei and Shigella flexneri 2a O-specific polysaccharide conjugates in children

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1662

Natural immunity to shigellosis in two groups with different previous risks of exposure to Shigella is only partly expressed by serum antibodies to lipopolysaccharide

31 March 2020

1 reference

https://api.crossref.org/works/10.1038%2FNRMICRO1662

Vaccine strain Sh. flexneri T32-Istrati. Studies in animals and in volunteers. Antidysentery immunoprophylaxis and immunotherapy by live vaccine Vadizen (Sh. flexneri T32-Istrati)

31 March 2020

1 reference

https://pubmed.ncbi.nlm.nih.gov/17558427

12 December 2020

Study on the effect of oral immunization of T32-Istrati strain against bacillary dysentery in field trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/17558427

12 December 2020

Prevention of bacillary dysentery using a live anti-dysentery vaccine in a group of neuropsychopathic children

1 reference

https://pubmed.ncbi.nlm.nih.gov/17558427

12 December 2020

Communitywide shigellosis: control of an outbreak and risk factors in child day-care centers

1 reference

https://pubmed.ncbi.nlm.nih.gov/17558427

12 December 2020

Future needs and directions for Shigella vaccines

1 reference

https://pubmed.ncbi.nlm.nih.gov/17558427

12 December 2020

https://pubmed.ncbi.nlm.nih.gov/17558427

1 reference

12 December 2020

Identifiers

DOI

10.1038/NRMICRO1662

1 reference

16 August 2017

1 reference

16 August 2017

PubMed publication ID

17558427

1 reference