CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders (Q36515176)

14 August 2017

CYP24 inhibition as a therapeutic target in FGF23-mediated renal phosphate wasting disorders (English)

1 reference

14 August 2017

2

1 reference

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11 June 2020

author name string

Xiuying Bai

1

1 reference

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11 June 2020

Sophia Xiao

3

1 reference

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11 June 2020

Dinghong Qiu

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26784541%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

René St-Arnaud

5

1 reference

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11 June 2020

Martin Petkovich

6

1 reference

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11 June 2020

Ajay Gupta

7

1 reference

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11 June 2020

David Goltzman

8

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26784541%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

Andrew C Karaplis

9

1 reference

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11 June 2020

language of work or name

English

0 references

publication date

19 January 2016

1 reference

14 August 2017

14

1 reference

Journal of Clinical Investigation

inferred from page(s)

published in

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11 June 2020

volume

126

1 reference

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11 June 2020

issue

2

1 reference

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11 June 2020

page(s)

667-680

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describes a project that uses

11 June 2020

ImageJ

1 reference

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC4731193/fullTextXML

inferred from PubMed Central ID database lookup

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Inhibition of protein kinase CK2 reduces Cyp24a1 expression and enhances 1,25-dihydroxyvitamin D(3) antitumor activity in human prostate cancer cells

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30 September 2017

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CYP24A1 inhibition enhances the antitumor activity of calcitriol

30 September 2017

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Treatment of X-linked hypophosphatemia with calcitriol and phosphate increases circulating fibroblast growth factor 23 concentrations

30 September 2017

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Human duodenum responses to vitamin D metabolites of TRPV6 and other genes involved in calcium absorption

30 September 2017

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The PHEX transgene corrects mineralization defects in 9-month-old hypophosphatemic mice.

30 September 2017

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The parathyroid is a target organ for FGF23 in rats

30 September 2017

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Vitamin D receptor in chondrocytes promotes osteoclastogenesis and regulates FGF23 production in osteoblasts

30 September 2017

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Evidence for auto/paracrine actions of vitamin D in bone: 1alpha-hydroxylase expression and activity in human bone cells

30 September 2017

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30 September 2017

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Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo

30 September 2017

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Transgenic mice overexpressing human fibroblast growth factor 23 (R176Q) delineate a putative role for parathyroid hormone in renal phosphate wasting disorders

30 September 2017

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Parathyroid hormone-related peptide is required for increased trabecular bone volume in parathyroid hormone-null mice

30 September 2017

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The autosomal dominant hypophosphatemic rickets R176Q mutation in fibroblast growth factor 23 resists proteolytic cleavage and enhances in vivo biological potency

30 September 2017

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Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production

30 September 2017

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Differential regulation of growth plate chondrocytes by 1alpha,25-(OH)2D3 and 24R,25-(OH)2D3 involves cell-maturation-specific membrane-receptor-activated phospholipid metabolism

30 September 2017

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Recruitment, augmentation and apoptosis of rat osteoclasts in 1,25-(OH)2D3 response to short-term treatment with 1,25-dihydroxyvitamin D3 in vivo

30 September 2017

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Autosomal-dominant hypophosphatemic rickets (ADHR) mutations stabilize FGF-23

30 September 2017

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Overexpression of Phex in osteoblasts fails to rescue the Hyp mouse phenotype.

30 September 2017

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Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia

30 September 2017

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Skin is an autonomous organ in synthesis, two-step activation and degradation of vitamin D(3): CYP27 in epidermis completes the set of essential vitamin D(3)-hydroxylases

30 September 2017

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Intracrinology: role of the family of 17 beta-hydroxysteroid dehydrogenases in human physiology and disease

30 September 2017

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Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities

30 September 2017

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Pex/PEX tissue distribution and evidence for a deletion in the 3' region of the Pex gene in X-linked hypophosphatemic mice

30 September 2017

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Cloning of the human 1α,25-dihydroxyvitamin D-3 24-hydroxylase gene promoter and identification of two vitamin D-responsive elements

30 September 2017

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Vitamin D and Intestinal Calcium Transport: Facts, Speculations and Hypotheses

30 September 2017

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A gene (PEX) with homologies to endopeptidases is mutated in patients with X-linked hypophosphatemic rickets. The HYP Consortium

30 September 2017

1 reference

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Healing of bone disease in X-linked hypophosphatemic rickets/osteomalacia. Induction and maintenance with phosphorus and calcitriol

30 September 2017

1 reference

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Increased renal catabolism of 1,25-dihydroxyvitamin D3 in murine X-linked hypophosphatemic rickets

30 September 2017

1 reference

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Effects of therapy in X-linked hypophosphatemic rickets

30 September 2017

1 reference

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Fibroblast growth factor 23 is a counter-regulatory phosphaturic hormone for vitamin D.

30 September 2017

1 reference

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Human osteoblasts in culture metabolize both 1 alpha, 25-dihydroxyvitamin D3 and its precursor 25-hydroxyvitamin D3 into their respective lactones

28 June 2018

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Expression of 25-hydroxyvitamin D3-24-hydroxylase activity in Caco-2 cells. An in vitro model of intestinal vitamin D catabolism

28 June 2018

1 reference

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Identification of the vitamin D receptor in osteoblasts and chondrocytes but not osteoclasts in mouse bone

28 June 2018

1 reference

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Pharmacological inhibition of fibroblast growth factor (FGF) receptor signaling ameliorates FGF23-mediated hypophosphatemic rickets.

21 September 2018

1 reference

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Deletion of the vitamin D receptor specifically in the parathyroid demonstrates a limited role for the receptor in parathyroid physiology

21 September 2018

1 reference

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Chondrocyte-specific modulation of Cyp27b1 expression supports a role for local synthesis of 1,25-dihydroxyvitamin D3 in growth plate development.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731193

Overexpression of human PHEX under the human beta-actin promoter does not fully rescue the Hyp mouse phenotype

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731193

Modulation of CYP27B1 and CYP24 mRNA expression in bone is independent of circulating 1,25(OH)2D3 levels.

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731193

Characterization of vitamin D-mediated induction of the CYP 24 transcription

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731193

Disordered regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase gene expression by phosphorus in X-linked hypophosphatemic (hyp) mice

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731193

Fibroblast growth factor 23 in oncogenic osteomalacia and X-linked hypophosphatemia

21 September 2018

1 reference

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Correction of the abnormal mineral ion homeostasis with a high-calcium, high-phosphorus, high-lactose diet rescues the PDDR phenotype of mice deficient for the 25-hydroxyvitamin D-1α-hydroxylase (CYP27B1)

21 September 2018

1 reference

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Partial rescue of the Hyp phenotype by osteoblast-targeted PHEX (phosphate-regulating gene with homologies to endopeptidases on the X chromosome) expression

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731193

Nephrolithiasis and osteoporosis associated with hypophosphatemia caused by mutations in the type 2a sodium-phosphate cotransporter

21 September 2018

1 reference

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Histochemical localization of alkaline phosphatase activity in decalcified bone and cartilage

21 September 2018

1 reference

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Relation between hypomineralized periosteocytic lesions and bone mineralization in vitamin D-resistant rickets

21 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4731193

Hypophosphataemic rickets: final height and clinical symptoms in adults

21 September 2018

1 reference

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Abnormal regulation of renal 25-hydroxyvitamin D-1alpha-hydroxylase activity in X-linked hypophosphatemia: a translational or post-translational defect

21 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Transgenic analysis of the response of the rat calbindin-D 9k gene to vitamin D

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Deficient mineralization of intramembranous bone in vitamin D-24-hydroxylase-ablated mice is due to elevated 1,25-dihydroxyvitamin D and not to the absence of 24,25-dihydroxyvitamin D

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Increased formation and decreased resorption of bone in mice with elevated vitamin D receptor in mature cells of the osteoblastic lineage

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Osteotropic agents regulate the expression of osteoclast differentiation factor and osteoprotegerin in osteoblastic stromal cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Early lethality in Hyp mice with targeted deletion of Pth gene

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Human bone cells in culture metabolize 25-hydroxyvitamin D3 to 1,25-dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Increased renal 25-hydroxyvitamin D3-24-hydroxylase messenger ribonucleic acid and immunoreactive protein in phosphate-deprived Hyp mice: a mechanism for accelerated 1,25-dihydroxyvitamin D3 catabolism in X-linked hypophosphatemic rickets

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Osteomalacia in hyp mice is associated with abnormal phex expression and with altered bone matrix protein expression and deposition

1 reference

https://pubmed.ncbi.nlm.nih.gov/26784541

12 December 2020

Identifiers

DOI

10.1172/JCI81928

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26784541%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26784541%20AND%20SRC:MED&resulttype=core&format=json

11 June 2020

PubMed publication ID

26784541

1 reference