Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells (Q36402419)

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English	Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells	scientific article

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scholarly article

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Europe PubMed Central

PMC publication ID

14 August 2017

Activation of PI3K is indispensable for interleukin 7-mediated viability, proliferation, glucose use, and growth of T cell acute lymphoblastic leukemia cells (English)

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

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1 reference

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lymphoblastic leukemia

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João T. Barata

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Joao T Barata

1

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4

object named as

Lee M Nadler

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Europe PubMed Central

PMC publication ID

14 August 2017

author name string

Ana Silva

2

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Europe PubMed Central

PMC publication ID

14 August 2017

Joana G Brandao

3

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Europe PubMed Central

PMC publication ID

14 August 2017

Angelo A Cardoso

5

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Europe PubMed Central

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14 August 2017

Vassiliki A Boussiotis

6

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Europe PubMed Central

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14 August 2017

language of work or name

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publication date

1 September 2004

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Europe PubMed Central

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14 August 2017

Journal of Experimental Medicine

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Europe PubMed Central

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14 August 2017

200

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Europe PubMed Central

PMC publication ID

14 August 2017

5

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Europe PubMed Central

PMC publication ID

14 August 2017

659-669

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Europe PubMed Central

PMC publication ID

14 August 2017

describes a project that uses

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Europe PubMed Central

11 June 2022

https://www.ebi.ac.uk/europepmc/webservices/rest/PMC2212738/fullTextXML

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IL-7-dependent human leukemia T-cell line as a valuable tool for drug discovery in T-ALL.

1 reference

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30 September 2017

Akt-Directed Glucose Metabolism Can Prevent Bax Conformation Change and Promote Growth Factor-Independent Survival

1 reference

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30 September 2017

In vitro evidence that cytokine receptor signals are required for differentiation of double positive thymocytes into functionally mature CD8+ T cells

1 reference

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30 September 2017

Why size matters: altering cell size

1 reference

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30 September 2017

Akt maintains cell size and survival by increasing mTOR-dependent nutrient uptake

1 reference

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30 September 2017

The CD28 signaling pathway regulates glucose metabolism

1 reference

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30 September 2017

Protein kinase B (Akt) regulation and function in T lymphocytes

1 reference

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30 September 2017

MAP kinases in the immune response

1 reference

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30 September 2017

Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus

1 reference

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30 September 2017

PI 3-K and T-cell activation: limitations of T-leukemic cell lines as signaling models.

1 reference

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30 September 2017

Growth factors can influence cell growth and survival through effects on glucose metabolism

1 reference

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30 September 2017

Chemistry and biology of eukaryotic iron metabolism

1 reference

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30 September 2017

Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1).

1 reference

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30 September 2017

Glycogen synthase kinase-3 inhibits the DNA binding activity of NFATc

1 reference

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30 September 2017

The biochemistry of apoptosis

1 reference

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30 September 2017

In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability

1 reference

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30 September 2017

Myc-enhanced expression of Cul1 promotes ubiquitin-dependent proteolysis and cell cycle progression

1 reference

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30 September 2017

Regulation of bad phosphorylation and association with Bcl-x(L) by the MAPK/Erk kinase

1 reference

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30 September 2017

New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

1 reference

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30 September 2017

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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30 September 2017

Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency

1 reference

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30 September 2017

Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization

1 reference

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30 September 2017

Cell cycle targets of Ras/Raf signalling

1 reference

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30 September 2017

The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NF-AT.

1 reference

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30 September 2017

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

1 reference

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30 September 2017

Activation of phosphatidylinositol 3-kinase is sufficient for cell cycle entry and promotes cellular changes characteristic of oncogenic transformation

1 reference

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30 September 2017

Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase

1 reference

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30 September 2017

Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt

1 reference

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30 September 2017

Ras activity late in G1 phase required for p27kip1 downregulation, passage through the restriction point, and entry into S phase in growth factor-stimulated NIH 3T3 fibroblasts

1 reference

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30 September 2017

The earliest T lineage-committed cells depend on IL-7 for Bcl-2 expression and normal cell cycle progression

1 reference

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30 September 2017

Transformation of chicken cells by the gene encoding the catalytic subunit of PI 3-kinase

1 reference

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30 September 2017

The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal.

1 reference

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30 September 2017

Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3

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30 September 2017

Prevention of apoptosis by Bcl-2: release of cytochrome c from mitochondria blocked

1 reference

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30 September 2017

Interleukin-7 induces T cell proliferation in the absence of Erk/MAP kinase activity

1 reference

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30 September 2017

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

1 reference

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30 September 2017

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice

1 reference

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30 September 2017

Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis

1 reference

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30 September 2017

The retinoblastoma protein and cell cycle control

1 reference

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30 September 2017

Interleukin 7 receptor engagement stimulates tyrosine phosphorylation, inositol phospholipid turnover, proliferation, and selective differentiation to the CD4 lineage by human fetal thymocytes

1 reference

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30 September 2017

Engagement of interleukin-7 receptor stimulates tyrosine phosphorylation, phosphoinositide turnover, and clonal proliferation of human T-lineage acute lymphoblastic leukemia cells

1 reference

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30 September 2017

Gene transfer of the interleukin (IL)-2 receptor beta chain into an IL-7-dependent pre-B cell line permits IL-2-driven proliferation: tyrosine phosphorylation of Shc is induced by IL-2 but not IL-7.

1 reference

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30 September 2017

Apoptosis is regulated by the rate of glucose transport in an interleukin 3 dependent cell line

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30 September 2017

Cutaneous lymphoproliferation and lymphomas in interleukin 7 transgenic mice

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28 June 2018

Vascular cell adhesion molecule 1-positive reticular cells express interleukin-7 and stem cell factor in the bone marrow

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28 June 2018

Thymic epithelial cells promote survival of human T-cell acute lymphoblastic leukemia blasts: the role of interleukin-7

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21 September 2018

Overexpression of IL-7R alpha provides a competitive advantage during early T-cell development.

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21 September 2018

Glucocorticoids inhibit cell cycle progression in differentiating osteoblasts via glycogen synthase kinase-3beta

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21 September 2018

IL-7 enhances the survival and maintains the size of naive T cells

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212738

21 September 2018

Interleukin-7 promotes survival and cell cycle progression of T-cell acute lymphoblastic leukemia cells by down-regulating the cyclin-dependent kinase inhibitor p27(kip1).

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212738

21 September 2018

Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway

1 reference

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21 September 2018

Induction of TCR gene rearrangements in uncommitted stem cells by a subset of IL-7 producing, MHC class-II-expressing thymic stromal cells.

1 reference

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21 September 2018

Selective requirement for MAP kinase activation in thymocyte differentiation.

1 reference

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21 September 2018

Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL).

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21 September 2018

CD28 costimulation mediates T cell expansion via IL-2-independent and IL-2-dependent regulation of cell cycle progression

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2212738

21 October 2018

Changes in glucose transport and transporter isoforms during the activation of human peripheral blood lymphocytes by phytohemagglutinin

1 reference

https://pubmed.ncbi.nlm.nih.gov/15353558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Cloning of a thymic stromal cell capable of protecting thymocytes from apoptosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/15353558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

JAK3 protein tyrosine kinase mediates interleukin-7-induced activation of phosphatidylinositol-3' kinase

1 reference

https://pubmed.ncbi.nlm.nih.gov/15353558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Distinct roles of the phosphatidylinositol 3-kinase and STAT5 pathways in IL-7-mediated development of human thymocyte precursors

1 reference

https://pubmed.ncbi.nlm.nih.gov/15353558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Inhibition of in vitro spontaneous apoptosis by IL-7 correlates with bcl-2 up-regulation, cortical/mature immunophenotype, and better early cytoreduction of childhood T-cell acute lymphoblastic leukemia

1 reference

https://pubmed.ncbi.nlm.nih.gov/15353558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An essential role for the IL-7 receptor during intrathymic expansion of the positively selected neonatal T cell repertoire

1 reference

https://pubmed.ncbi.nlm.nih.gov/15353558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

CD28 costimulation mediates down-regulation of p27kip1 and cell cycle progression by activation of the PI3K/PKB signaling pathway in primary human T cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/15353558

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1084/JEM.20040789

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PMC publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

PubMed publication ID

1 reference

Europe PubMed Central

PMC publication ID

14 August 2017

ResearchGate publication ID

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