Journey through the thymus: stromal guides for T-cell development and selection (Q36402237)

14 August 2017

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title

Journey through the thymus: stromal guides for T-cell development and selection (English)

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14 August 2017

Yousuke Takahama

1

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14 August 2017

language of work or name

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1 February 2006

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Nature Reviews Immunology

14 August 2017

published in

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14 August 2017

volume

6

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14 August 2017

issue

2

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14 August 2017

page(s)

127-135

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IMMUNOLOGICAL FUNCTION OF THE THYMUS

14 August 2017

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RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

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Deficient T cell fate specification in mice with an induced inactivation of Notch1.

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T-cell development made simple

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Positive selection of thymocytes

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Directed migration of positively selected thymocytes visualized in real time

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21 January 2018

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21 January 2018

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Positional cloning of the APECED gene

21 January 2018

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An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

21 January 2018

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Projection of an immunological self shadow within the thymus by the aire protein

21 January 2018

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Aire regulates negative selection of organ-specific T cells

21 January 2018

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Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation

21 January 2018

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21 January 2018

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21 January 2018

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Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus

21 January 2018

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Compartmentalized production of CCL17 in vivo: strong inducibility in peripheral dendritic cells contrasts selective absence from the spleen.

21 January 2018

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Macrophage-derived chemokine and EBI1-ligand chemokine attract human thymocytes in different stage of development and are produced by distinct subsets of medullary epithelial cells: possible implications for negative selection

21 January 2018

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A pertussis toxin-sensitive process controls thymocyte emigration

21 January 2018

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Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1

21 January 2018

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Expression of the sphingosine 1-phosphate receptor, S1P1, on T-cells controls thymic emigration

21 January 2018

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Role for CCR7 ligands in the emigration of newly generated T lymphocytes from the neonatal thymus

21 January 2018

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Thymocyte emigration is mediated by active movement away from stroma-derived factors

21 January 2018

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Thymic microvascular system.

21 January 2018

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Compartmentalized Eph receptor and ephrin expression in the thymus

21 January 2018

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Intrathymic T-cell migration: a combinatorial interplay of extracellular matrix and chemokines?

21 January 2018

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Thymic generation and regeneration

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21 January 2018

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Efficient generation of human T cells from a tissue-engineered thymic organoid

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From stem cell to T cell: one route or many?

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T/B lineage choice occurs prior to intrathymic Notch signaling.

21 January 2018

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Notch signaling controls the generation and differentiation of early T lineage progenitors

21 January 2018

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A multipotent precursor in the thymus maps to the branching point of the T versus B lineage decision

21 January 2018

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Expression and function of chemokine receptors on human thymocytes: implications for infection by human immunodeficiency virus type 1.

21 January 2018

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Murine CCR9, a chemokine receptor for thymus-expressed chemokine that is up-regulated following pre-TCR signaling

21 January 2018

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Expression of CCR9 beta-chemokine receptor is modulated in thymocyte differentiation and is selectively maintained in CD8+ T cells from secondary lymphoid organs

21 January 2018

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Developmental regulation of T-cell receptor gene expression

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Positive selection of antigen-specific T cells in thymus by restricting MHC molecules

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Selecting and maintaining a diverse T-cell repertoire

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Disorganization and restoration of thymic medullary epithelial cells in T cell receptor-negative scid mice: evidence that receptor-bearing lymphocytes influence maturation of the thymic microenvironment

31 March 2020

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Chemokines define distinct microenvironments in the developing thymus

31 March 2020

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Recruitment of adult thymic progenitors is regulated by P-selectin and its ligand PSGL-1

31 March 2020

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Cutting edge: thymocyte-independent and thymocyte-dependent phases of epithelial patterning in the fetal thymus

31 March 2020

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Maturation of medullary thymic epithelium requires thymocytes expressing fully assembled CD3-TCR complexes

31 March 2020

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In Vivo Treatment of Class II MHC-Deficient Mice with Anti-TCR Antibody Restores the Generation of Circulating CD4 T Cells and Optimal Architecture of Thymic Medulla

31 March 2020

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Development of autoimmunity against transcriptionally unrepressed target antigen in the thymus of Aire-deficient mice

31 March 2020

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A scanning electron-microscopic study of the rat thymus with special reference to cell types and migration of lymphocytes into the general circulation

31 March 2020

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Stromal cells provide the matrix for migration of early lymphoid progenitors through the thymic cortex

31 March 2020

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Involvement of E-cadherin in thymus organogenesis and thymocyte maturation

31 March 2020

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Enhancement of stromal cell-derived factor-1alpha-induced chemotaxis for CD4/8 double-positive thymocytes by fibronectin and laminin in mice

31 March 2020

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Heterogeneity among DN1 prothymocytes reveals multiple progenitors with different capacities to generate T cell and non-T cell lineages

31 March 2020

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Characterization of CCR9 expression and CCL25/thymus-expressed chemokine responsiveness during T cell development: CD3(high)CD69+ thymocytes and gammadeltaTCR+ thymocytes preferentially respond to CCL25

31 March 2020

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Stromal-derived factor 1 expression in the human thymus

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/NRI1781

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14 August 2017

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