Epigenetic therapy of cancer: past, present and future (Q36399557)

14 August 2017

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title

Epigenetic therapy of cancer: past, present and future (English)

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14 August 2017

Christine B Yoo

1

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14 August 2017

Peter A Jones

series ordinal

2

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14 August 2017

publication date

1 January 2006

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Nature Reviews Drug Discovery

14 August 2017

published in

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14 August 2017

volume

5

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14 August 2017

issue

1

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14 August 2017

page(s)

37-50

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DNA methylation patterns and epigenetic memory

14 August 2017

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31 March 2020

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Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells

31 March 2020

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Loss of acetylation at Lys16 and trimethylation at Lys20 of histone H4 is a common hallmark of human cancer

31 March 2020

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Global histone modification patterns predict risk of prostate cancer recurrence

31 March 2020

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Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription

31 March 2020

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Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases.

31 March 2020

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HhaI methyltransferase flips its target base out of the DNA helix

31 March 2020

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On the mechanism of inhibition of DNA-cytosine methyltransferases by cytosine analogs

31 March 2020

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Covalent bond formation between a DNA-cytosine methyltransferase and DNA containing 5-azacytosine

31 March 2020

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Zebularine: A Novel DNA Methylation Inhibitor that Forms a Covalent Complex with DNA Methyltransferases

31 March 2020

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5-Aza-deoxycytidine induces selective degradation of DNA methyltransferase 1 by a proteasomal pathway that requires the KEN box, bromo-adjacent homology domain, and nuclear localization signal

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in hematopoietic malignancies

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Pharmacokinetics of 5-azacitidine administered with phenylbutyrate in patients with refractory solid tumors or hematologic malignancies.

31 March 2020

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Synthesis and antitumor activity of dihydro-5-azacytidine, a hydrolytically stable analogue of 5-azacytidine

31 March 2020

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Contrasting Cytotoxicity Kinetics of 5-Azacytidine and Dihydro-5-azacytidine Hydrochloride in L1210 Leukemia in Mice2, 3

31 March 2020

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Micronuclei induced by modulators of methylation: analogs of 5-azacytidine.

31 March 2020

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Biochemical pharmacology and DNA methylation studies of arabinosyl 5-azacytidine and 5,6-dihydro-5-azacytidine in two human leukemia cell lines PER-145 and PER-163.

31 March 2020

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31 March 2020

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Direct identification of the active-site nucleophile in a DNA (cytosine-5)-methyltransferase

31 March 2020

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Improved synthesis of zebularine [1-(beta-D-ribofuranosyl)-dihydropyrimidin-2-one] nucleotides as inhibitors of human deoxycytidylate deaminase

31 March 2020

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Binding of pyrimidin-2-one ribonucleoside by cytidine deaminase as the transition-state analogue 3,4-dihydrouridine and the contribution of the 4-hydroxyl group to its binding affinity

31 March 2020

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Synthesis of pyrimidin-2-one nucleosides as acid-stable inhibitors of cytidine deaminase

31 March 2020

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Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase

31 March 2020

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Antitumor properties of 2(1H)-pyrimidinone riboside (zebularine) and its fluorinated analogues.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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In living color: DNA methyltransferase caught in the act

31 March 2020

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Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks

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31 March 2020

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Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine.

31 March 2020

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31 March 2020

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31 March 2020

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31 March 2020

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Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t(14;18) lymphomas

31 March 2020

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Valproic acid inhibits angiogenesis in vitro and in vivo

31 March 2020

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Expression profiling of sodium butyrate (NaB)-treated cells: identification of regulation of genes related to cytokine signaling and cancer metastasis by NaB.

31 March 2020

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Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation

31 March 2020

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Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells

31 March 2020

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Sodium butyrate inhibits histone deacetylation in cultured cells

31 March 2020

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The effect of sodium butyrate on histone modification

31 March 2020

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Antileukemia activity of the combination of 5-aza-2'-deoxycytidine with valproic acid

31 March 2020

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The histone deacetylase inhibitor valproic acid selectively induces proteasomal degradation of HDAC2

31 March 2020

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Alpha-lipoic acid induces p27Kip-dependent cell cycle arrest in non-transformed cell lines and apoptosis in tumor cell lines.

31 March 2020

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Phase I study of an oral histone deacetylase inhibitor, suberoylanilide hydroxamic acid, in patients with advanced cancer

31 March 2020

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Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors

31 March 2020

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31 March 2020

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N-hydroxy-3-phenyl-2-propenamides as novel inhibitors of human histone deacetylase with in vivo antitumor activity: discovery of (2E)-N-hydroxy-3-[4-[[(2-hydroxyethyl)[2-(1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide (NVP-LAQ824).

31 March 2020

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A phase 1 and pharmacodynamic study of depsipeptide (FK228) in chronic lymphocytic leukemia and acute myeloid leukemia.

31 March 2020

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A phase I trial of depsipeptide (FR901228) in patients with advanced cancer.

31 March 2020

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Inhibitor of histone deacetylation, depsipeptide (FR901228), in the treatment of peripheral and cutaneous T-cell lymphoma: a case report

31 March 2020

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The Discovery of NVP-LAQ824: From Concept to Clinic

31 March 2020

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Structure, histone deacetylase, and antiprotozoal activities of apicidins B and C, congeners of apicidin with proline and valine substitutions

31 March 2020

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Novel histone deacetylase inhibitors: cyclic tetrapeptide with trifluoromethyl and pentafluoroethyl ketones

31 March 2020

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Cyclic tetrapeptides bearing a sulfhydryl group potently inhibit histone deacetylases.

31 March 2020

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Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand.

31 March 2020

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A synthetic inhibitor of histone deacetylase, MS-27-275, with marked in vivo antitumor activity against human tumors

31 March 2020

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Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275.

31 March 2020

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Epigenetic modulation of retinoic acid receptor beta2 by the histone deacetylase inhibitor MS-275 in human renal cell carcinoma

31 March 2020

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Phase I study of oral CI-994 in combination with carboplatin and paclitaxel in the treatment of patients with advanced solid tumors

31 March 2020

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Chronic oral administration of CI-994: a phase 1 study

31 March 2020

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A phase I study of the oral combination of CI-994, a putative histone deacetylase inhibitor, and capecitabine

31 March 2020

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Zebularine: a new drug for epigenetic therapy

31 March 2020

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Phase II trial of cisplatin plus decitabine, a new DNA hypomethylating agent, in patients with advanced squamous cell carcinoma of the cervix

31 March 2020

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A phase I trial of cisplatin plus decitabine, a new DNA-hypomethylating agent, in patients with advanced solid tumors and a follow-up early phase II evaluation in patients with inoperable non-small cell lung cancer

31 March 2020

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The power and the promise of DNA methylation markers

31 March 2020

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A crack in histone lysine methylation.

31 March 2020

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The language of covalent histone modifications

31 March 2020

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Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

31 March 2020

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The histone modification pattern of active genes revealed through genome-wide chromatin analysis of a higher eukaryote

31 March 2020

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Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14.

31 March 2020

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Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

31 March 2020

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Meiotic catastrophe and retrotransposon reactivation in male germ cells lacking Dnmt3L

31 March 2020

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Dnmt3L and the establishment of maternal genomic imprints

31 March 2020

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Histone modifying and chromatin remodelling enzymes in cancer and dysplastic syndromes

31 March 2020

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Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins

31 March 2020

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Unsafe SETs: histone lysine methyltransferases and cancer

31 March 2020

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Histone methylation in transcriptional control

31 March 2020

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Reversing histone methylation

31 March 2020

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Impact of azacytidine on the quality of life of patients with myelodysplastic syndrome treated in a randomized phase III trial: a Cancer and Leukemia Group B study

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Modulation of angiogenesis-related protein synthesis by valproic acid

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Phase I trial of continuous infusion 5-aza-2'-deoxycytidine

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inferred from DOI database lookup

7 January 2021

based on heuristic

Pilot phase I-II study on 5-aza-2'-deoxycytidine (Decitabine) in patients with metastatic lung cancer

1 reference

https://api.crossref.org/works/10.1038%2FNRD1930

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/NRD1930

1 reference

Dimensions Publication ID

14 August 2017

1021896263

0 references

1 reference