The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? (Q36268324)

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English	The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?	scientific article

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7 January 2020

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The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it? (English)

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7 January 2020

Richard A. Franklin

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7 January 2020

James A. McCubrey

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7 January 2020

Linda S Steelman

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Linda S Steelman

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7 January 2020

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John G Shelton

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7 January 2020

Steve L Abrams

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7 January 2020

Fred E Bertrand

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7 January 2020

Martin McMahon

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7 January 2020

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1 October 2005

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7 January 2020

Expert Opinion on Therapeutic Targets

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7 January 2020

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7 January 2020

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7 January 2020

1009-1030

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7 January 2020

ERBB receptors and cancer: the complexity of targeted inhibitors

1 reference

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Structure and specific sequences of avian erythroblastosis virus RNA: Evidence for multiple classes of transforming genes among avian tumor viruses

1 reference

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Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

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Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus

1 reference

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21 January 2018

Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo.

1 reference

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21 January 2018

The product of the avian erythroblastosis virus erbB locus is a glycoprotein

1 reference

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21 January 2018

Identification of a form of the avian erythroblastosis virus erb-B gene product at the cell surface

1 reference

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21 January 2018

The erbB gene of avian erythroblastosis virus is a member of the src gene family

1 reference

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21 January 2018

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

1 reference

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21 January 2018

Autophosphorylation sites on the epidermal growth factor receptor.

1 reference

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21 January 2018

Human epidermal growth factor receptor cDNA is homologous to a variety of RNAs overproduced in A431 carcinoma cells.

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21 January 2018

Amplification of a novel v-erbB-related gene in a human mammary carcinoma

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21 January 2018

Amplification and enhanced expression of the epidermal growth factor receptor gene in A431 human carcinoma cells.

1 reference

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21 January 2018

Protein phosphorylation at tyrosine is induced by the v-erbB gene product in vivo and in vitro.

1 reference

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21 January 2018

Antibodies against a synthetic peptide as a probe for the kinase activity of the avian EGF receptor and v-erbB protein

1 reference

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21 January 2018

Ligand-independent oncogenic transformation by the EGF receptor requires kinase domain catalytic activity

1 reference

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21 January 2018

Membrane localization of v-ErbB is required but not sufficient for ligand-independent transformation

1 reference

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21 January 2018

Amplification, enhanced expression and possible rearrangement of EGF receptor gene in primary human brain tumours of glial origin

1 reference

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21 January 2018

A chimeric, ligand-binding v-erbB/EGF receptor retains transforming potential

1 reference

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21 January 2018

Genetic determinants of neoplastic transformation by the retroviral oncogene v-erbB.

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21 January 2018

Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor

1 reference

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21 January 2018

PTEN mutation, EGFR amplification, and outcome in patients with anaplastic astrocytoma and glioblastoma multiforme.

1 reference

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21 January 2018

Erbin suppresses the MAP kinase pathway

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21 January 2018

Untangling the ErbB signalling network

1 reference

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21 January 2018

Single-molecule imaging of EGFR signalling on the surface of living cells

1 reference

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21 January 2018

TACE is required for the activation of the EGFR by TGF-alpha in tumors

1 reference

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21 January 2018

Regulated migration of epidermal growth factor receptor from caveolae

1 reference

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21 January 2018

Second cysteine-rich region of epidermal growth factor receptor contains targeting information for caveolae/rafts

1 reference

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21 January 2018

Crystal structure of a truncated epidermal growth factor receptor extracellular domain bound to transforming growth factor alpha

1 reference

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21 January 2018

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1 reference

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21 January 2018

Activation of preformed EGF receptor dimers by ligand-induced rotation of the transmembrane domain

1 reference

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21 January 2018

Epidermal growth factor receptor signaling

1 reference

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21 January 2018

Epidermal growth factor receptors: critical mediators of multiple receptor pathways

1 reference

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21 January 2018

Tyrosine phosphorylation of the EGF receptor by the kinase Jak2 is induced by growth hormone

1 reference

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21 January 2018

The ErbB signaling network: receptor heterodimerization in development and cancer

1 reference

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21 January 2018

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity

1 reference

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21 January 2018

Amplified and rearranged epidermal growth factor receptor genes in human glioblastomas reveal deletions of sequences encoding portions of the N- and/or C-terminal tails

1 reference

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21 January 2018

Interaction of Hsp90 with the nascent form of the mutant epidermal growth factor receptor EGFRvIII.

1 reference

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21 January 2018

Signal transduction, cell cycle regulatory, and anti-apoptotic pathways regulated by IL-3 in hematopoietic cells: possible sites for intervention with anti-neoplastic drugs

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21 January 2018

Extracellular domains drive homo- but not hetero-dimerization of erbB receptors

1 reference

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21 January 2018

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor

1 reference

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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JAK/STAT, Raf/MEK/ERK, PI3K/Akt and BCR-ABL in cell cycle progression and leukemogenesis

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Treatment by design in leukemia, a meeting report, Philadelphia, Pennsylvania, December 2002.

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Differential effects of kinase cascade inhibitors on neoplastic and cytokine-mediated cell proliferation

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Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

1 reference

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21 January 2018

Src phosphorylation of the epidermal growth factor receptor at novel sites mediates receptor interaction with Src and P85 alpha

1 reference

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21 January 2018

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

1 reference

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Regulation of cell death protease caspase-9 by phosphorylation

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21 January 2018

The complexity of PTEN: mutation, marker and potential target for therapeutic intervention

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PIK3CA gene is frequently mutated in breast carcinomas and hepatocellular carcinomas.

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21 January 2018

Activation of PI3K/Akt pathway by PTEN reduction and PIK3CA mRNA amplification contributes to cisplatin resistance in an ovarian cancer cell line

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21 January 2018

Identification of both positive and negative domains within the epidermal growth factor receptor COOH-terminal region for signal transducer and activator of transcription (STAT) activation

1 reference

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21 January 2018

ErbB receptor-induced activation of stat transcription factors is mediated by Src tyrosine kinases

1 reference

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21 January 2018

STAT5b, a Mediator of Synergism between c-Src and the Epidermal Growth Factor Receptor

1 reference

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21 January 2018

Stat3 activation is required for cellular transformation by v-src

1 reference

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21 January 2018

Role of STATs as downstream signal transducers in Src family kinase-mediated tumorigenesis

1 reference

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21 January 2018

The autocrine loop of TGF-alpha/EGFR and brain tumors

1 reference

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21 January 2018

PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients.

1 reference

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21 January 2018

Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer

1 reference

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21 January 2018

Monoclonal antibodies as effective therapeutic agents for solid tumors

1 reference

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21 January 2018

Targeted therapy in breast cancer: the HER-2/neu gene and protein

1 reference

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21 January 2018

Targeting the EGF receptor in breast cancer treatment

1 reference

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21 January 2018

Small molecules with EGFR-TK inhibitor activity

1 reference

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21 January 2018

Inhibition of the epidermal growth factor receptor in combined modality treatment for locally advanced non-small cell lung cancer

1 reference

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21 January 2018

Antitumor efficacy of cytotoxic drugs and the monoclonal antibody 806 is enhanced by the EGF receptor inhibitor AG1478.

1 reference

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21 January 2018

Epidermal growth factor receptor inhibitors in the treatment of non-small-cell lung cancer.

1 reference

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21 January 2018

Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme

1 reference

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21 January 2018

Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types.

1 reference

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21 January 2018

Gefitinib in patients with brain metastases from non-small-cell lung cancer: a prospective trial

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21 January 2018

Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib

1 reference

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21 January 2018

Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways

1 reference

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21 January 2018

EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib

1 reference

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21 January 2018

EGFR mutation and resistance of non-small-cell lung cancer to gefitinib

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21 January 2018

Acquired resistance of lung adenocarcinomas to gefitinib or erlotinib is associated with a second mutation in the EGFR kinase domain

1 reference

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21 January 2018

Guilty as charged: B-RAF is a human oncogene

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21 January 2018

EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy

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21 January 2018

A functional polymorphism in the EGF gene is found with increased frequency in glioblastoma multiforme patients and is associated with more aggressive disease

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21 January 2018

Effects of a conditionally active v-ErbB and an EGF-R inhibitor on transformation of NIH-3T3 cells and abrogation of cytokine dependency of hematopoietic cells

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21 January 2018

Effects of endogenous epidermal growth factor receptor signaling on DNA synthesis and ERK activation in a cytokine-dependent hematopoietic cell line

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21 January 2018

Conditional EGFR promotes cell cycle progression and prevention of apoptosis in the absence of autocrine cytokines

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21 January 2018

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10.1517/14728222.9.5.1009

1 reference

Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16185155%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:16185155%20AND%20SRC:MED&resulttype=core&format=json

7 January 2020

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