Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells. (Q36231919)

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20 February 2020

title

Anti-tumoral effect of desmethylclomipramine in lung cancer stem cells (English)

1 reference

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20 February 2020

main subject

neoplastic stem cells

1 reference

1 reference

4

1 reference

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20 February 2020

Angelo Peschiaroli

6

1 reference

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20 February 2020

5

Ruggero De Maria

1 reference

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20 February 2020

author name string

Lucilla Bongiorno-Borbone

1

1 reference

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20 February 2020

Arianna Giacobbe

2

1 reference

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20 February 2020

Mirco Compagnone

3

1 reference

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20 February 2020

Gerry Melino

7

1 reference

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20 February 2020

language of work or name

English

0 references

publication date

1 July 2015

1 reference

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20 February 2020

1 reference

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20 February 2020

volume

6

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20 February 2020

issue

19

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20 February 2020

page(s)

16926-16938

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IL-8 confers resistance to EGFR inhibitors by inducing stem cell properties in lung cancer.

20 February 2020

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Mir-509-5p joins the Mdm2/p53 feedback loop and regulates cancer cell growth

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1 October 2017

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Inappropriate p53 activation during development induces features of CHARGE syndrome

1 October 2017

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p53-dependent Nestin regulation links tumor suppression to cellular plasticity in liver cancer

1 October 2017

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Discovery of a p53 variant that controls metastasis

1 October 2017

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p53Ψ is a transcriptionally inactive p53 isoform able to reprogram cells toward a metastatic-like state.

1 October 2017

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Elimination of quiescent/slow-proliferating cancer stem cells by Bcl-XL inhibition in non-small cell lung cancer

1 October 2017

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Combined autophagy and proteasome inhibition: a phase 1 trial of hydroxychloroquine and bortezomib in patients with relapsed/refractory myeloma

1 October 2017

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Integrated high-throughput analysis identifies Sp1 as a crucial determinant of p53-mediated apoptosis

1 October 2017

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1 October 2017

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1 October 2017

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P53-regulated long non-coding RNA TUG1 affects cell proliferation in human non-small cell lung cancer, partly through epigenetically regulating HOXB7 expression

1 October 2017

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The onset of p53 loss of heterozygosity is differentially induced in various stem cell types and may involve the loss of either allele

1 October 2017

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Palmdelphin, a novel target of p53 with Ser46 phosphorylation, controls cell death in response to DNA damage

1 October 2017

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p63 and p73 coordinate p53 function to determine the balance between survival, cell death, and senescence in adult neural precursor cells

1 October 2017

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1 October 2017

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1 October 2017

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Mutant p53 drives pancreatic cancer metastasis through cell-autonomous PDGF receptor β signaling

1 October 2017

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p53 Induces skin aging by depleting Blimp1+ sebaceous gland cells

1 October 2017

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Unequal prognostic potentials of p53 gain-of-function mutations in human cancers associate with drug-metabolizing activity

1 October 2017

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Endogenous c-Myc is essential for p53-induced apoptosis in response to DNA damage in vivo

1 October 2017

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A positive feedback between p53 and miR-34 miRNAs mediates tumor suppression.

1 October 2017

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Antitumor effect of miR-197 targeting in p53 wild-type lung cancer.

1 October 2017

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ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis.

1 October 2017

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miR-16 and miR-26a target checkpoint kinases Wee1 and Chk1 in response to p53 activation by genotoxic stress

1 October 2017

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USP7 inhibitor P22077 inhibits neuroblastoma growth via inducing p53-mediated apoptosis

1 October 2017

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Autophagy and chemotherapy resistance: a promising therapeutic target for cancer treatment

1 October 2017

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Lung cancer tumorigenicity and drug resistance are maintained through ALDH(hi)CD44(hi) tumor initiating cells

1 October 2017

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1 October 2017

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SET1 and p300 act synergistically, through coupled histone modifications, in transcriptional activation by p53

1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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1 October 2017

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MicroRNAs in the p53 network: micromanagement of tumour suppression

1 October 2017

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Therapeutic targeting of Chk1 in NSCLC stem cells during chemotherapy.

1 October 2017

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1 October 2017

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The E3 ubiquitin ligase WWP1 regulates ΔNp63-dependent transcription through Lys63 linkages

1 October 2017

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Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway

1 October 2017

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Role of autophagy in suppression of inflammation and cancer

1 October 2017

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Autophagy suppresses tumorigenesis through elimination of p62

1 October 2017

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1 October 2017

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Principles of cancer therapy: oncogene and non-oncogene addiction

1 October 2017

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Autophagic cell death: the story of a misnomer

1 October 2017

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Akt inhibition promotes autophagy and sensitizes PTEN-null tumors to lysosomotropic agents

1 October 2017

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TAp73 knockout shows genomic instability with infertility and tumor suppressor functions

1 October 2017

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Itch self-polyubiquitylation occurs through lysine-63 linkages

1 October 2017

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The HECT family of E3 ubiquitin ligases: multiple players in cancer development

1 October 2017

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Itch: a HECT-type E3 ligase regulating immunity, skin and cancer

1 October 2017

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Structural basis for sorting mechanism of p62 in selective autophagy

1 October 2017

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The impact of p53 and p73 on aneuploidy and cancer

1 October 2017

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Approaches to mitochondrially mediated cancer therapy

1 October 2017

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Autophagy in the Pathogenesis of Disease

1 October 2017

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Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis

1 October 2017

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Antimalarial therapy prevents Myc-induced lymphoma

1 October 2017

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Identification and expansion of the tumorigenic lung cancer stem cell population

1 October 2017

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Role of autophagy in cancer

1 October 2017

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Itch inhibition regulates chemosensitivity in vitro

1 October 2017

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Autophagy suppresses tumor progression by limiting chromosomal instability

1 October 2017

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Tricyclic antidepressant pharmacology and therapeutic drug interactions updated

1 October 2017

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Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Constitutive autophagy: vital role in clearance of unfavorable proteins in neurons.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

One, two, three--p53, p63, p73 and chemosensitivity.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Lung cancer: diagnosis and management.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Finding new tricks for old drugs: an efficient route for public-sector drug discovery

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

The antioxidant function of the p53 tumor suppressor

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

The role of autophagy in cancer development and response to therapy.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

The ubiquitin-protein ligase Itch regulates p73 stability

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Proteasome inhibition in the treatment of cancer

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

The treatment of limited small cell lung cancer: a report of the progress made and future prospects

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

1 October 2017

The Hallmarks of Cancer

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Modulation of alternative splicing contributes to cancer development: focusing on p53 isoforms, p53β and p53γ.

1 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Expanding the reach of the p53 tumor suppressor network

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Stem cell-like ALDH(bright) cellular states in EGFR-mutant non-small cell lung cancer: a novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

PPISURV: a novel bioinformatics tool for uncovering the hidden role of specific genes in cancer survival outcome

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Tumor suppression in the absence of p53-mediated cell-cycle arrest, apoptosis, and senescence

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Not all p53 gain-of-function mutants are created equal

29 June 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Aldehyde dehydrogenase-1 is a specific marker for stem cells in human lung adenocarcinoma.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

The p53 family: guardians of maternal reproduction

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Selectively killing transformed cells through proteasome inhibition

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Caspase cleavage of Itch in chronic lymphocytic leukemia cells.

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

Chlorimipramine: a novel anticancer agent with a mitochondrial target

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

22 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4627282

The potential of proteasome inhibitors in cancer therapy

5 December 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/26219257

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.18632/ONCOTARGET.4700

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26219257%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26219257%20AND%20SRC:MED&resulttype=core&format=json

20 February 2020

PubMed publication ID

26219257

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26219257%20AND%20SRC:MED&resulttype=core&format=json