Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface. (Q36161950)

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24 February 2020

title

Synthesis and characterization of a lubricin mimic (mLub) to reduce friction and adhesion on the articular cartilage surface (English)

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24 February 2020

2

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24 February 2020

Sarah Calve

4

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24 February 2020

Alyssa Panitch

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24 February 2020

author name string

Alexandra Lawrence

1

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24 February 2020

Melissa D Bible

3

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24 February 2020

Corey P Neu

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24 February 2020

language of work or name

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11 September 2015

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24 February 2020

number of pages

9

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inferred from page(s)

published in

Biomaterials

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24 February 2020

volume

73

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24 February 2020

page(s)

42-50

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Both hyaluronan and collagen type II keep proteoglycan 4 (lubricin) at the cartilage surface in a condition that provides low friction during boundary lubrication

24 February 2020

cites work

1 reference

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Preservation of the structure of enzymatically-degraded bovine vitreous using synthetic proteoglycan mimics

2 October 2017

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Interaction of lubricin with type II collagen surfaces: adsorption, friction, and normal forces

2 October 2017

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Dependence of nanoscale friction and adhesion properties of articular cartilage on contact load.

2 October 2017

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Effects of supplemental intra-articular lubricin and hyaluronic acid on the progression of posttraumatic arthritis in the anterior cruciate ligament-deficient rat knee.

2 October 2017

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Increased friction coefficient and superficial zone protein expression in patients with advanced osteoarthritis

2 October 2017

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Atomic force microscope investigation of the boundary-lubricant layer in articular cartilage.

2 October 2017

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Biotribology of articular cartilage--a review of the recent advances

2 October 2017

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Regulation of the friction coefficient of articular cartilage by TGF-beta1 and IL-1beta

2 October 2017

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Decreased lubricin concentrations and markers of joint inflammation in the synovial fluid of patients with anterior cruciate ligament injury

2 October 2017

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Biofunctional polymer nanoparticles for intra-articular targeting and retention in cartilage

2 October 2017

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Proteoglycan 4 downregulation in a sheep meniscectomy model of early osteoarthritis

2 October 2017

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Consequences of disease-causing mutations on lubricin protein synthesis, secretion, and post-translational processing.

2 October 2017

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The secreted glycoprotein lubricin protects cartilage surfaces and inhibits synovial cell overgrowth

2 October 2017

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Microscale frictional response of bovine articular cartilage from atomic force microscopy

2 October 2017

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Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking

2 October 2017

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Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures

2 October 2017

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The role of lubricant entrapment at biological interfaces: reduction of friction and adhesion in articular cartilage.

2 October 2017

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Prevention of cartilage degeneration and restoration of chondroprotection by lubricin tribosupplementation in the rat following anterior cruciate ligament transection.

2 July 2018

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Biomimetic aggrecan reduces cartilage extracellular matrix from degradation and lowers catabolic activity in ex vivo and in vivo models

2 July 2018

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A large-molecular-weight polyanion, synthesized via ring-opening metathesis polymerization, as a lubricant for human articular cartilage.

23 September 2018

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Tribological altruism: A sacrificial layer mechanism of synovial joint lubrication in articular cartilage.

23 September 2018

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The boundary lubrication of chemically grafted and cross-linked hyaluronic acid in phosphate buffered saline and lipid solutions measured by the surface forces apparatus

23 September 2018

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The effect of molecular weight on hyaluronan's cartilage boundary lubricating ability--alone and in combination with proteoglycan 4.

23 September 2018

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Mechanotransduction of bovine articular cartilage superficial zone protein by transforming growth factor beta signaling

23 September 2018

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PRG4 exchange between the articular cartilage surface and synovial fluid

23 September 2018

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Boundary lubrication of articular cartilage: role of synovial fluid constituents

23 September 2018

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Chondroitin sulfate reduces the friction coefficient of articular cartilage

23 September 2018

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Investigation into the effects of proteins and lipids on the frictional properties of articular cartilage.

23 September 2018

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A critical role for collagen II in cartilage matrix degradation: collagen II induces pro-inflammatory cytokines and MMPs in primary human chondrocytes

23 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/26398308

12 December 2020

Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury

1 reference

https://pubmed.ncbi.nlm.nih.gov/26398308

12 December 2020

Bioregulation of lubricin expression by growth factors and cytokines

1 reference

https://pubmed.ncbi.nlm.nih.gov/26398308

12 December 2020

Localization of proteoglycan monomer and link protein in the matrix of bovine articular cartilage: An immunohistochemical study

1 reference

https://pubmed.ncbi.nlm.nih.gov/26398308

12 December 2020

Spontaneous cartilage degeneration in guinea pigs

1 reference

https://pubmed.ncbi.nlm.nih.gov/26398308

12 December 2020

Molecular Aspects of Boundary Lubrication by Human Lubricin: Effect of Disulfide Bonds and Enzymatic Digestion†

1 reference

https://pubmed.ncbi.nlm.nih.gov/26398308

12 December 2020

Synthesis and characterization of an aggrecan mimic

1 reference

https://pubmed.ncbi.nlm.nih.gov/26398308

12 December 2020

10.1016/J.BIOMATERIALS.2015.09.012

Identifiers

DOI

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:26398308%20AND%20SRC:MED&resulttype=core&format=json

24 February 2020

1 reference

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24 February 2020

PubMed publication ID

26398308

1 reference