DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur (Q36117781)

12 August 2017

DSL ligand endocytosis physically dissociates Notch1 heterodimers before activating proteolysis can occur (English)

1 reference

12 August 2017

1 reference

James T Nichols

1

1 reference

12 August 2017

Alison Miyamoto

2

1 reference

12 August 2017

Samantha L Olsen

3

1 reference

12 August 2017

Brendan D'Souza

4

1 reference

12 August 2017

Christine Yao

5

1 reference

12 August 2017

Gerry Weinmaster

6

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12 August 2017

language of work or name

English

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publication date

1 February 2007

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12 August 2017

14

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based on heuristic

inferred from page(s)

published in

Journal of Cell Biology

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12 August 2017

176

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12 August 2017

4

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12 August 2017

445-458

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GTP-dependent twisting of dynamin implicates constriction and tension in membrane fission

12 August 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Why is delta endocytosis required for effective activation of notch?

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Dynamin and the actin cytoskeleton cooperatively regulate plasma membrane invagination by BAR and F-BAR proteins

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Endocytic regulation of Notch activation and down-regulation (review).

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

The divergent DSL ligand Dll3 does not activate Notch signaling but cell autonomously attenuates signaling induced by other DSL ligands

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

The roles of receptor and ligand endocytosis in regulating Notch signaling

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Notch subunit heterodimerization and prevention of ligand-independent proteolytic activation depend, respectively, on a novel domain and the LNR repeats

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Rac-dependent trans-endocytosis of ephrinBs regulates Eph-ephrin contact repulsion

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Down-regulation of Delta by proteolytic processing

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Ligand-induced signaling in the absence of furin processing of Notch1.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Ligand endocytosis drives receptor dissociation and activation in the Notch pathway

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Regulated intramembrane proteolysis: a control mechanism conserved from bacteria to humans

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Calcium depletion dissociates and activates heterodimeric notch receptors

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Metalloprotease-disintegrins: modular proteins capable of promoting cell-cell interactions and triggering signals by protein-ectodomain shedding.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Ligand-receptor interactions and trans-endocytosis of Delta, Serrate and Notch: members of the Notch signalling pathway in Drosophila.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Complex proteolytic processing acts on Delta, a transmembrane ligand for Notch, during Drosophila development

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

The Notch1 receptor is cleaved constitutively by a furin-like convertase

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

AP-2/Eps15 interaction is required for receptor-mediated endocytosis

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Antineurogenic phenotypes induced by truncated Notch proteins indicate a role in signal transduction and may point to a novel function for Notch in nuclei

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Jagged: A mammalian ligand that activates notch1

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

EphB-ephrinB bi-directional endocytosis terminates adhesion allowing contact mediated repulsion.

2 October 2017

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Notch receptor activation inhibits oligodendrocyte differentiation

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Requirement for dynamin during Notch signaling in Drosophila neurogenesis.

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

The bride of sevenless and sevenless interaction: internalization of a transmembrane ligand

2 July 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

Unequal segregation of Neuralized biases Notch activation during asymmetric cell division

2 July 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.200609014

Specific truncations of Drosophila Notch define dominant activated and dominant negative forms of the receptor.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.200609014

Requirements for presenilin-dependent cleavage of notch and other transmembrane proteins.

21 January 2018

1 reference

Crossref

https://api.crossref.org/works/10.1083%2FJCB.200609014

Snail is required for Delta endocytosis and Notch-dependent activation of single-minded expression.

21 January 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling

23 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=2063980

A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1

23 September 2018

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17296795

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Immobilization of Notch ligand, Delta-1, is required for induction of notch signaling

1 reference

PubMed

https://pubmed.ncbi.nlm.nih.gov/17296795

inferred from PubMed ID database lookup

12 December 2020

based on heuristic

Identifiers

DOI

10.1083/JCB.200609014

1 reference

12 August 2017

1 reference

12 August 2017

PubMed publication ID

17296795

1 reference