From magic bullets to designed multiple ligands (Q35848618)

10 August 2017

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title

From magic bullets to designed multiple ligands (English)

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10 August 2017

Richard Morphy

1

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10 August 2017

Corinne Kay

series ordinal

2

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10 August 2017

Zoran Rankovic

series ordinal

3

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10 August 2017

language of work or name

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1 August 2004

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10 August 2017

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10 August 2017

volume

9

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10 August 2017

issue

15

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10 August 2017

page(s)

641-651

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Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor

10 August 2017

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

The effects of a selective D4 dopamine receptor antagonist (L-745,870) in acutely psychotic inpatients with schizophrenia. D4 Dopamine Antagonist Group

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

Pyrrolo[1,3]benzothiazepine-based serotonin and dopamine receptor antagonists. Molecular modeling, further structure-activity relationship studies, and identification of novel atypical antipsychotic agents

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

New targets for antipsychotics

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

Comparative efficacy between venlafaxine and SSRIs: a pooled analysis of patients with depression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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A new class of ibuprofen derivatives with reduced gastrotoxicity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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"Mixed inhibitor-prodrug" as a new approach toward systemically active inhibitors of enkephalin-degrading enzymes

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Design and synthesis of a novel synthetic NAPAP-penta-saccharide conjugate displaying a dual antithrombotic action.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

Identification of a series of PPAR gamma/delta dual agonists via solid-phase parallel synthesis

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Selective optimization of side activities: another way for drug discovery

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Duloxetine (Cymbalta), a dual inhibitor of serotonin and norepinephrine reuptake

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Indoline and piperazine containing derivatives as a novel class of mixed D(2)/D(4) receptor antagonists. Part 2: asymmetric synthesis and biological evaluation

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Development of a new class of nonimidazole histamine H(3) receptor ligands with combined inhibitory histamine N-methyltransferase activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Macrocyclic bisindolylmaleimides as inhibitors of protein kinase C and glycogen synthase kinase-3.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Molecular properties that influence the oral bioavailability of drug candidates

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Dual angiotensin converting enzyme/thromboxane synthase inhibitors

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

Synthesis of [[(benzenesulfonamido)alkyl]phenyl]alkanoic acid derivatives containing pyridyl or imidazolyl groups and their thromboxane A2 receptor antagonistic and thromboxane A2 synthase inhibitory activities

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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DPI-3290 [(+)-3-((α-R)-α-((2S,5R)-4-Allyl-2,5-dimethyl-1-piperazinyl)-3-hydroxybenzyl)-N-(3-fluorophenyl)-N-methylbenzamide]. I. A Mixed Opioid Agonist with Potent Antinociceptive Activity

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Bicyclo[2.2.1]heptanes as novel triple re-uptake inhibitors for the treatment of depression

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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The design and synthesis of novel NK1/NK2 dual antagonists

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Dipeptide sulfonamides as endothelin ETA/ETB receptor antagonists.

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

7 January 2021

Amphipathic 3-phenyl-7-propylbenzisoxazoles; human pPaR gamma, delta and alpha agonists

1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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1 reference

https://api.crossref.org/works/10.1016%2FS1359-6446%2804%2903163-0

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Large Dimeric Ligands with Favorable Pharmacokinetic Properties and Peroxisome Proliferator-Activated Receptor Agonist Activity in Vitro and in Vivo

1 reference

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CGS 34226, a thiol-based dual inhibitor of endothelin converting enzyme-1 and neutral endopeptidase 24.11.

1 reference

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Systematic discovery of multicomponent therapeutics

1 reference

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7 January 2021

10.1016/S1359-6446(04)03163-0

Identifiers

DOI

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10 August 2017

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