HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity (Q35832992)

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5 March 2020

title

HIPK2 deficiency causes chromosomal instability by cytokinesis failure and increases tumorigenicity (English)

1 reference

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5 March 2020

6

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5 March 2020

Armando Bartolazzi

8

1 reference

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5 March 2020

Silvia Soddu

11

1 reference

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5 March 2020

Cinzia Rinaldo

12

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5 March 2020

author name string

Davide Valente

1

1 reference

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5 March 2020

Gianluca Bossi

2

1 reference

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5 March 2020

Alice Moncada

3

1 reference

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5 March 2020

Mara Tornincasa

4

1 reference

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5 March 2020

Stefania Indelicato

5

1 reference

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5 March 2020

Eva Diamantis Karamitopoulou

7

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5 March 2020

Giovanna Maria Pierantoni

9

1 reference

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5 March 2020

Alfredo Fusco

10

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5 March 2020

language of work or name

English

0 references

publication date

1 April 2015

1 reference

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5 March 2020

1 reference

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5 March 2020

volume

6

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5 March 2020

issue

12

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5 March 2020

page(s)

10320-10334

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describes a project that uses

5 March 2020

ImageJ

1 reference

11 June 2022

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inferred from PubMed Central ID database lookup

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HIPK2 controls cytokinesis and prevents tetraploidization by phosphorylating histone H2B at the midbody

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Hipk2 cooperates with p53 to suppress γ-ray radiation-induced mouse thymic lymphoma

27 July 2018

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The loss of the p53 activator HIPK2 is responsible for galectin-3 overexpression in well differentiated thyroid carcinomas

27 July 2018

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Illicit survival of cancer cells during polyploidization and depolyploidization

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Transcription factor NF-Y induces apoptosis in cells expressing wild-type p53 through E2F1 upregulation and p53 activation.

27 July 2018

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27 July 2018

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Homeodomain-interacting protein kinase 2 plays an important role in normal terminal erythroid differentiation

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A mechanism linking extra centrosomes to chromosomal instability

27 July 2018

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HIPK2 is involved in cell proliferation and its suppression promotes growth arrest independently of DNA damage.

27 July 2018

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HIPK2 represses beta-catenin-mediated transcription, epidermal stem cell expansion, and skin tumorigenesis

27 July 2018

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Mutations of the HIPK2 gene in acute myeloid leukemia and myelodysplastic syndrome impair AML1- and p53-mediated transcription

27 July 2018

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27 July 2018

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Cytokinesis failure generating tetraploids promotes tumorigenesis in p53-null cells

27 July 2018

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Interaction of Brn3a and HIPK2 mediates transcriptional repression of sensory neuron survival

27 July 2018

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27 July 2018

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17p (p53) allelic losses, 4N (G2/tetraploid) populations, and progression to aneuploidy in Barrett's esophagus

27 July 2018

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Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

27 July 2018

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A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.

27 July 2018

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HIPK2 phosphorylates ΔNp63α and promotes its degradation in response to DNA damage.

24 September 2018

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Role of the SUMO-interacting motif in HIPK2 targeting to the PML nuclear bodies and regulation of p53.

24 September 2018

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Proliferation of aneuploid human cells is limited by a p53-dependent mechanism.

24 September 2018

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https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

HIPK2 and cancer cell resistance to therapy.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

Precursors to pancreatic cancer

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

HIPK2: a multitalented partner for transcription factors in DNA damage response and development.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

Overlapping roles for homeodomain-interacting protein kinases hipk1 and hipk2 in the mediation of cell growth in response to morphogenetic and genotoxic signals

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

Tetraploidy and tumor development.

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

Tetraploidy and chromosomal instability are early events during cervical carcinogenesis

24 September 2018

1 reference

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Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformation

24 September 2018

1 reference

https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pmc&linkname=pmc_refs_pubmed&retmode=json&id=4496358

Centrosome abnormalities in pancreatic ductal carcinoma.

24 September 2018

1 reference

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K-ras, p53, and DPC4 (MAD4) alterations in fine-needle aspirates of the pancreas: a molecular panel correlates with and supplements cytologic diagnosis

24 September 2018

1 reference

https://pubmed.ncbi.nlm.nih.gov/25868975

12 December 2020

p53 deficiency exacerbates pleiotropic mitotic defects, changes in nuclearity and polyploidy in transdifferentiating pancreatic acinar cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/25868975

12 December 2020

HMGA1 and HMGA2 protein expression correlates with advanced tumour grade and lymph node metastasis in pancreatic adenocarcinoma

1 reference

https://pubmed.ncbi.nlm.nih.gov/25868975

12 December 2020

Pancreatic adenocarcinoma: update on the surgical pathology of carcinomas of ductal origin and PanINs

1 reference

https://pubmed.ncbi.nlm.nih.gov/25868975

12 December 2020

DNA content of hyperplastic and neoplastic acinar cell lesions in rat and human pancreas

1 reference

https://pubmed.ncbi.nlm.nih.gov/25868975

12 December 2020

Identifiers

DOI

10.18632/ONCOTARGET.3583

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868975%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868975%20AND%20SRC:MED&resulttype=core&format=json

5 March 2020

PubMed publication ID

25868975

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25868975%20AND%20SRC:MED&resulttype=core&format=json