The therapeutic potential of CRF1 antagonists for anxiety (Q35814456)

10 August 2017

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title

The therapeutic potential of CRF1 antagonists for anxiety (English)

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10 August 2017

2

George F Koob

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10 August 2017

Eric P Zorrilla

1

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10 August 2017

language of work or name

English

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publication date

1 July 2004

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Expert Opinion on Investigational Drugs

10 August 2017

published in

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10 August 2017

volume

13

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10 August 2017

issue

7

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10 August 2017

page(s)

799-828

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Economic costs of anxiety disorders.

10 August 2017

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Urocortin is the principal ligand for the corticotrophin-releasing factor binding protein in the ovine brain with no evidence for a sauvagine-like peptide

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Corticotropin releasing factor (CRF) binding protein: a novel regulator of CRF and related peptides

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In vivo and in vitro characterization of antalarmin, a nonpeptide corticotropin-releasing hormone (CRH) receptor antagonist: suppression of pituitary ACTH release and peripheral inflammation

21 January 2018

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Corticotropin releasing factor receptor 1-deficient mice display decreased anxiety, impaired stress response, and aberrant neuroendocrine development

21 January 2018

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Central administration of corticotropin-releasing factor modulates oxytocin secretion in the rat.

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Central Nervous System Regulation of Adrenocorticotropin Secretion: Role of Somatostatins*

21 January 2018

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Lessons from CRH knockout mice

21 January 2018

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Increase of urocortin-like immunoreactivity in the rat supraoptic nucleus after dehydration but not food deprivation

21 January 2018

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The CRF peptide family and their receptors: yet more partners discovered

21 January 2018

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Distribution of mRNAs encoding CRF receptors in brain and pituitary of rat and mouse

21 January 2018

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Distribution of corticotropin-releasing factor receptor mRNA expression in the rat brain and pituitary

21 January 2018

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EEG stability following corticotropin releasing factor in rats

21 January 2018

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CRF-induced seizures and behavior: interaction with amygdala kindling

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Corticotropin-releasing hormone is a rapid and potent convulsant in the infant rat

21 January 2018

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21 January 2018

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The CRF1 receptor mediates the excitatory actions of corticotropin releasing factor (CRF) in the developing rat brain: in vivo evidence using a novel, selective, non-peptide CRF receptor antagonist

21 January 2018

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CP-154,526: a potent and selective nonpeptide antagonist of corticotropin releasing factor receptors.

21 January 2018

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Corticotropin releasing factor produces behavioural activation in rats.

21 January 2018

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21 January 2018

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21 January 2018

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Intracerebroventricular porcine corticotropin-releasing hormone and cortisol effects on pig immune measures and behavior

21 January 2018

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21 January 2018

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21 January 2018

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CRF-induced excessive grooming behavior in rats and mice

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21 January 2018

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Rapid changes in monoamine levels following administration of corticotropin-releasing factor or corticosterone are localized in the dorsomedial hypothalamus

21 January 2018

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Corticotropin-releasing factor (CRF) antagonist suppresses stress-induced locomotor activity in an amphibian

21 January 2018

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21 January 2018

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CRF antagonist reverses the "anxiogenic" response to ethanol withdrawal in the rat.

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Intracerebroventricularly administered corticotropin-releasing factor inhibits food intake and produces anxiety-like behaviour at very low doses in mice

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CRF and restraint-stress decrease exploratory behavior in hypophysectomized mice

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The effect of corticotropin-releasing factor (CRF) on autonomic and behavioral responses during shock-prod burying test in rats

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Repeated stress, like vasopressin, sensitizes the excitatory effects of corticotropin releasing factor on the acoustic startle reflex

21 January 2018

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Effects of nicotine and stress on startle amplitude and sensory gating depend on rat strain and sex.

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Locus coeruleus involvement in the effects of immobilization stress on the p13 midlatency auditory evoked potential in the rat.

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Baseline startle amplitude and prepulse inhibition in Vietnam veterans with posttraumatic stress disorder

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Prepulse inhibition deficits in patients with panic disorder

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Impaired P50 sensory gating in post-traumatic stress disorder secondary to urban violence

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Sensory gating in chronic posttraumatic stress disorder: reduced auditory P50 suppression in combat veterans

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Combat veterans with posttraumatic stress disorder exhibit decreased habituation of the P1 midlatency auditory evoked potential

21 January 2018

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Differential behavioral actions of corticotropin-releasing factor (CRF)

21 January 2018

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Corticotropin-releasing factor enhances sodium and water intake/excretion in rabbits

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Behavioral and physiologic effects of CRH administered to infant primates undergoing maternal separation

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Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates

21 January 2018

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21 January 2018

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Intra-amygdala injections of corticotropin releasing factor facilitate inhibitory avoidance learning and reduce exploratory behavior in rats

21 January 2018

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Role of corticotropin-releasing factor and urocortin within the basolateral amygdala of rats in anxiety and panic responses

21 January 2018

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Neuropeptide Y Y1 receptor-mediated anxiolysis in the dorsocaudal lateral septum: functional antagonism of corticotropin-releasing hormone-induced anxiety.

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The Impact of the Nonpeptide Corticotropin-Releasing Hormone Antagonist Antalarmin on Behavioral and Endocrine Responses to Stress1

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Urocortin shares the memory modulating effects of corticotropin-releasing factor (CRF): mediation by CRF1 receptors

21 January 2018

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Interaction between the cholinergic system and CRH in the modulation of spatial discrimination learning in mice

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Regional hemodynamic responses to central administration of corticotropin-releasing factor (CRF).

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Comparison of hCRF and oCRF effects on cardiovascular responses after central, peripheral, and in vitro application.

21 January 2018

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Autonomic and behavioral effects of centrally administered corticotropin-releasing factor in rats

21 January 2018

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Behavioral and cardiac responses after intracerebroventricular corticotropin-releasing hormone (CRH) administration: role of adrenal cortical hormones

21 January 2018

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Corticotropin-releasing factor induces differential behavioral and cardiovascular effects after intracerebroventricular and lateral hypothalamic/perifornical injections in rats

21 January 2018

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Physiological and behavioral effects of chronic intracerebroventricular infusion of corticotropin-releasing factor in the rat.

21 January 2018

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Central actions of CRF on thermogenesis are mediated by pro-opiomelanocortin products

21 January 2018

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Central urocortin activation of sympathetic-regulated energy metabolism in Wistar rats

21 January 2018

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Long-term effects on feeding and body weight after stimulation of forebrain or hindbrain CRH receptors with urocortin

21 January 2018

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Corticotropin-releasing factor receptor antagonist: effects on the autonomic nervous system and cardiovascular function

21 January 2018

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Prevalence of irritable bowel syndrome among university students: the roles of worry, neuroticism, anxiety sensitivity and visceral anxiety

21 January 2018

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Comorbidity of irritable bowel syndrome in psychiatric patients: a review.

21 January 2018

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Elevated CSF corticotropin-releasing factor concentrations in posttraumatic stress disorder

21 January 2018

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Corticotropin-releasing factor in posttraumatic stress disorder (PTSD) with secondary psychotic symptoms, nonpsychotic PTSD, and healthy control subjects

21 January 2018

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Elevated cerebrospinal fluid levels of immunoreactive corticotropin-releasing hormone in anorexia nervosa: relation to state of nutrition, adrenal function, and intensity of depression

21 January 2018

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The role of corticotropin-releasing factor in depression and anxiety disorders

21 January 2018

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Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims

21 January 2018

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Dysregulation in the suicide brain: mRNA expression of corticotropin-releasing hormone receptors and GABA(A) receptor subunits in frontal cortical brain region.

21 January 2018

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Abnormalities in the regulation of vasopressin and corticotropin releasing factor secretion in obsessive-compulsive disorder

21 January 2018

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Changes in Cerebrospinal Fluid Neurochemistry During Treatment of Obsessive-compulsive Disorder With Clomipramine

21 January 2018

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Cerebrospinal fluid neurochemistry in children and adolescents with obsessive-compulsive disorder

21 January 2018

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Cerebrospinal fluid neuropeptides in mood disorder and dementia

21 January 2018

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The effects of chronic treatment with the mood stabilizers valproic acid and lithium on corticotropin-releasing factor neuronal systems

21 January 2018

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Potent, structurally constrained agonists and competitive antagonists of corticotropin-releasing factor

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Astressin analogues (corticotropin-releasing factor antagonists) with extended duration of action in the rat.

21 January 2018

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Brain corticotropin-releasing hormone increases arousal in stress

21 January 2018

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Psychological stress increases arousal through brain corticotropin-releasing hormone without significant increase in adrenocorticotropin and catecholamine secretion

21 January 2018

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Restraint changes pentobarbital-induced sleeping time in rats: evidence that arousal is modulated by brain corticotropin-releasing hormone and opioid in stress

21 January 2018

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Hyperactivity of central noradrenergic and CRF systems is involved in social isolation-induced decrease in pentobarbital sleep

21 January 2018

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A corticotropin-releasing factor antagonist reverses the stress-induced changes of exploratory behavior in mice

21 January 2018

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The role of corticotropin-releasing factor in the anxiogenic effects of ethanol withdrawal

21 January 2018

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Anti-stress action of a corticotropin-releasing factor antagonist on behavioral reactivity to stressors of varying type and intensity

21 January 2018

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Corticotropin-releasing factor antagonist reduces emotionality in socially defeated rats via direct neurotropic action

21 January 2018

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Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal

21 January 2018

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Corticotropin releasing factor antagonist, alpha-helical CRF(9-41), reverses nicotine-induced conditioned, but not unconditioned, anxiety

21 January 2018

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Conditioned increases in anxiogenic-like behavior following exposure to contextual stimuli associated with cocaine are mediated by corticotropin-releasing factor

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Antagonism of corticotropin-releasing factor attenuates the enhanced responsiveness to stress observed during protracted ethanol abstinence

21 January 2018

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Behavioral effects of central administration of the novel CRF antagonist astressin in rats.

21 January 2018

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Antagonism of endogenous CRH systems attenuates stress-induced freezing behavior in rats

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Fear-motivated behavior induced by prior shock experience is mediated by corticotropin-releasing hormone systems

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Effect of corticotropin-releasing factor antagonist on behavioral and neuroendocrine responses during exposure to defensive burying paradigm in rats

21 January 2018

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Antagonism of corticotropin-releasing factor receptors in the locus coeruleus attenuates shock-induced freezing in rats

21 January 2018

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CRH signalling in the bed nucleus of the stria terminalis is involved in stress-induced cardiac vagal activation in conscious rats

21 January 2018

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Endogenous corticotropin-releasing hormone inhibits conditioned-fear-induced vagal activation in the rat.

21 January 2018

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Conditioned emotional response in rats enhances colonic motility through the central release of corticotropin-releasing factor

21 January 2018

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Water-avoidance stress-induced c-fos expression in the rat brain and stimulation of fecal output: role of corticotropin-releasing factor

21 January 2018

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Alpha-helical CRF(9-41) prevents anxiogenic-like effect of NPY Y1 receptor antagonist BIBP3226 in rats.

21 January 2018

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Role of endogenous corticotropin-releasing factor in mediation of neuroendocrine and behavioral responses to cholecystokinin octapeptide sulfate ester in rats.

21 January 2018

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Characterization of the behavioral profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone

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Corticotropin releasing factor (CRF) receptor antagonist blocks activating and 'anxiogenic' actions of CRF in the rat.

21 January 2018

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Neuropeptide Y blocks anxiogenic-like behavioral action of corticotropin-releasing factor in an operant conflict test and elevated plus maze

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Corticotropin-releasing factor receptor blockade enhances conditioned aversive properties of cocaine in rats.

21 January 2018

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The neurobiology and control of anxious states

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Animal model for investigating the anxiogenic effects of self-administered cocaine

21 January 2018

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Involvement of stress-released corticotropin-releasing hormone in the basolateral amygdala in regulating memory consolidation

21 January 2018

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Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei--potential implication for arousal and attention

21 January 2018

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Critical role of endogenous corticotropin-releasing factor (CRF) in the mediation of the behavioral action of cocaine in rats

21 January 2018

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Reduced anxiety-like and cognitive performance in mice lacking the corticotropin-releasing factor receptor 1.

21 January 2018

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Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1.

21 January 2018

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Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress.

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Differential behavioural effects of chronic infusion of CRH 1 and CRH 2 receptor antisense oligonucleotides into the rat brain

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Chronic infusion of a CRH1 receptor antisense oligodeoxynucleotide into the central nucleus of the amygdala reduced anxiety-related behavior in socially defeated rats

21 January 2018

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Corticotropin-releasing hormone receptor (type I) antisense targeting reduces anxiety

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Corticotropin-releasing factor CRF1, but not CRF2, receptors mediate anxiogenic-like behavior

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Role of CRF(1) and CRF(2) receptors in fear and anxiety

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Therapeutic potential of CRF receptor antagonists: a gut-brain perspective

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4-(2-Chloro-4-methoxy-5-methylphenyl)-N-[(1S)-2-cyclopropyl-1-(3-fluoro-4-methylphenyl)ethyl]5-methyl-N-(2-propynyl)-1,3-thiazol-2-amine hydrochloride (SSR125543A): a potent and selective corticotrophin-releasing factor(1) receptor antagonist. I. Bi

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Arylamidrazones as novel corticotropin releasing factor receptor antagonists

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Synthesis and biological activity of oxo-7H-benzo[e]perimidine-4-carboxylic acid derivatives as potent, nonpeptide corticotropin releasing factor (CRF) receptor antagonists

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Synthesis, molecular modeling and biological activity of methyl and thiomethyl substituted pyrimidines as corticotropin releasing hormone type 1 antagonists.

21 January 2018

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Mechanism of corticotropin-releasing factor type I receptor regulation by nonpeptide antagonists

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Sigma receptors: from discovery to highlights of their implications in the cardiovascular system

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Neuropeptide Y receptor subtypes

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CRHR1 Receptor binding and lipophilicity of pyrrolopyrimidines, potential nonpeptide corticotropin-releasing hormone type 1 receptor antagonists

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Imidazo[4,5-c]pyridines as corticotropin releasing factor receptor ligands

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Imidazo[4,5-b]pyridines as corticotropin releasing factor receptor ligands

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Synthesis of 3-phenylpyrazolo[4,3-b]pyridines via a convenient synthesis of 4-amino-3-arylpyrazoles and SAR of corticotropin-releasing factor receptor type-1 antagonists

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Synthesis and SAR of 8-arylquinolines as potent corticotropin-releasing factor1 (CRF1) receptor antagonists

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Synthesis of 1-methyl-3-phenylpyrazolo[4,3-b]pyridines via a methylation of 4-phthalimino-3-phenylpyrazoles and optimization toward highly potent corticotropin-releasing factor type-1 antagonists

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Brain penetrance, receptor occupancy and antistress in vivo efficacy of a small molecule corticotropin releasing factor type I receptor selective antagonist

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Oral administration of a corticotropin-releasing hormone receptor antagonist significantly attenuates behavioral, neuroendocrine, and autonomic responses to stress in primates

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Brain pharmacokinetics of a nonpeptidic corticotropin-releasing factor receptor antagonist

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Receptor occupancy of nonpeptide corticotropin-releasing factor 1 antagonist DMP696: correlation with drug exposure and anxiolytic efficacy

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Hydrophobicity and central nervous system agents: on the principle of minimal hydrophobicity in drug design

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Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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Is there a difference between leads and drugs? A historical perspective

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Lercanidipine : a review of its efficacy in the management of hypertension

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Stress-induced behaviors require the corticotropin-releasing hormone (CRH) receptor, but not CRH.

21 January 2018

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Corticotropin-releasing factor receptor type 1 mediates emotional stress-induced inhibition of food intake and behavioral changes in rats

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Non-peptidic corticotropin-releasing hormone receptor type 1 antagonist reverses restraint stress-induced shortening of sodium pentobarbital-induced sleeping time of rats: evidence that an increase in arousal induced by stress is mediated through CR

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The CRH1 receptor antagonist R121919 attenuates stress-elicited sleep disturbances in rats, particularly in those with high innate anxiety

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The anxiolytic CRF(1) antagonist DMP696 fails to function as a discriminative stimulus and does not substitute for chlordiazepoxide in rats

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Effect of chronic administration of a CRF(1) receptor antagonist, CRA1000, on locomotor activity and endocrine responses to stress

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Survival of a 75% burn in a patient with longstanding Addison's disease

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Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes

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Antalarmin, a putative CRH-RI antagonist, has transient reinforcing effects in rhesus monkeys

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Corticotropin-releasing hormone antagonists, astressin B and antalarmin: differing profiles of activity in rhesus monkeys

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Effects of the high-affinity corticotropin-releasing hormone receptor 1 antagonist R121919 in major depression: the first 20 patients treated

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Treatment with the CRH1-receptor-antagonist R121919 improves sleep-EEG in patients with depression

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Treatment of depression with the CRH-1-receptor antagonist R121919: endocrine changes and side effects

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Synthesis and characterization of fluorinated and iodinated pyrrolopyrimidines as PET/SPECT ligands for the CRF1 receptor

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Antischizophrenic drugs: chronic treatment elevates dopamine receptor binding in brain

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Pyrazolo-[1,5-a]-1,3,5-triazine corticotropin-releasing factor (CRF) receptor ligands

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Corticotropin releasing factor (CRF) receptor modulators: progress and opportunities for new therapeutic agents

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A novel water-soluble selective CRF1 receptor antagonist, NBI 35965, blunts stress-induced visceral hyperalgesia and colonic motor function in rats

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Neuroprotective effects of the CRF1 antagonist R121920 after permanent focal ischemia in the rat.

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Anxiolytic properties of the selective, non-peptidergic CRF(1) antagonists, CP154,526 and DMP695: a comparison to other classes of anxiolytic agent

21 January 2018

1 reference

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The anxiolytic effect of the CRH(1) receptor antagonist R121919 depends on innate emotionality in rats

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.799

The CRF(1) receptor antagonist DMP696 produces anxiolytic effects and inhibits the stress-induced hypothalamic-pituitary-adrenal axis activation without sedation or ataxia in rats

21 January 2018

1 reference

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The effects of CRA 1000, a non-peptide antagonist of corticotropin-releasing factor receptor type 1, on adaptive behaviour in the rat.

21 January 2018

1 reference

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Effects of a non-peptide CRF antagonist (DMP696) on the behavioral and endocrine sequelae of maternal separation

21 January 2018

1 reference

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Modulation of multiple ethanol withdrawal-induced anxiety-like behavior by CRF and CRF1 receptors

21 January 2018

1 reference

https://api.crossref.org/works/10.1517%2F13543784.13.7.799

Effects of the CRF(1) receptor antagonist, CP 154,526, in the separation-induced vocalization anxiolytic test in rat pups

21 January 2018

1 reference

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Involvement of corticotropin-releasing factor in the retrieval process of fear-conditioned ultrasonic vocalization in rats

21 January 2018

1 reference

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Suppression of conditioned fear by administration of CRF receptor antagonist CP-154,526.

21 January 2018

1 reference

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Attenuation of fear conditioning by antisense inhibition of brain corticotropin releasing factor-2 receptor

21 January 2018

1 reference

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Synthesis and oral efficacy of a 4-(butylethylamino)pyrrolo[2,3-d]pyrimidine: a centrally active corticotropin-releasing factor1 receptor antagonist

21 January 2018

1 reference

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A non peptidic corticotropin releasing factor receptor antagonist attenuates fever and exhibits anxiolytic-like activity

21 January 2018

1 reference

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Peripheral administration of CRF and urocortin: effects on food intake and the HPA axis in the marsupial Sminthopsis crassicaudata

21 January 2018

1 reference

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Chronic effects of a nonpeptide corticotropin-releasing hormone type I receptor antagonist on pituitary-adrenal function, body weight, and metabolic regulation.

21 January 2018

1 reference

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Enhanced corticotropin response to corticotropin-releasing hormone as a predictor of mania in euthymic bipolar patients

21 January 2018

1 reference

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Relationships between feeding and locomotion behaviors after central administration of CRF in chicks

21 January 2018

1 reference

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10.1517/13543784.13.7.799

21 January 2018

Identifiers

DOI

1 reference

10 August 2017

1 reference