A decade of discoveries in cardiac biology (Q35762460)

10 August 2017

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title

A decade of discoveries in cardiac biology (English)

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10 August 2017

Eric N Olson

1

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10 August 2017

language of work or name

English

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publication date

1 May 2004

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10 August 2017

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10 August 2017

volume

10

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10 August 2017

issue

5

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10 August 2017

page(s)

467-474

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Incidence of congenital heart disease: I. Postnatal incidence.

10 August 2017

cites work

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https://api.crossref.org/works/10.1038%2FNM0504-467

Wnt antagonism initiates cardiogenesis in Xenopus laevis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Inhibition of Wnt activity induces heart formation from posterior mesoderm

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

tinman and bagpipe: two homeo box genes that determine cell fates in the dorsal mesoderm of Drosophila

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Csx: a murine homeobox-containing gene specifically expressed in the developing heart

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

MEF2: a calcium-dependent regulator of cell division, differentiation and death

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

GATA-dependent recruitment of MEF2 proteins to target promoters

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Cardiac tissue enriched factors serum response factor and GATA-4 are mutual coregulators

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Activation of cardiac gene expression by myocardin, a transcriptional cofactor for serum response factor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Regulation of chamber-specific gene expression in the developing heart by Irx4.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Cardiosensor mice and transcriptional subdomains of the vertebrate heart.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

The anterior heart-forming field: voyage to the arterial pole of the heart

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Cardiac left-right development: are the early steps conserved?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

A subclass of bHLH proteins required for cardiac morphogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

The combinatorial activities of Nkx2.5 and dHAND are essential for cardiac ventricle formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Parsing the heart: genetic modules for organ assembly

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

ErbB2 pathways in heart and neural diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Erythropoietin and retinoic acid, secreted from the epicardium, are required for cardiac myocyte proliferation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Molecular markers of cardiac endocardial cushion development.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

A novel role for cardiac neural crest in heart development

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Transcriptional regulation of cardiac development: implications for congenital heart disease and DiGeorge syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Endothelin-induced conversion of embryonic heart muscle cells into impulse-conducting Purkinje fibers

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Neuregulin-1 promotes formation of the murine cardiac conduction system

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

A genetic blueprint for cardiac development

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Congenital heart disease caused by mutations in the transcription factor NKX2-5

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Mutations in human TBX5 [corrected] cause limb and cardiac malformation in Holt-Oram syndrome

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Sizing up the heart: development redux in disease.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Myocardial gene expression in dilated cardiomyopathy treated with beta-blocking agents

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Activated glycogen synthase-3 beta suppresses cardiac hypertrophy in vivo

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Myocyte-enriched calcineurin-interacting protein, MCIP1, inhibits cardiac hypertrophy in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Death by design. Programmed cell death in cardiovascular biology and disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Genomic circuits and the integrative biology of cardiac diseases

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Gq signaling in cardiac adaptation and maladaptation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

A calcineurin-dependent transcriptional pathway for cardiac hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Decoding calcium signals involved in cardiac growth and function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Cytoplasmic signaling pathways that regulate cardiac hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Activation and function of cyclin T-Cdk9 (positive transcription elongation factor-b) in cardiac muscle-cell hypertrophy.

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Role of the natriuretic peptide system in cardiorenal protection

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Improving clinical outcomes with drug treatment in heart failure: what have trials taught?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Seven-transmembrane-spanning receptors and heart function

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

The neurohormonal hypothesis: a theory to explain the mechanism of disease progression in heart failure

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Adrenergic pathways and left ventricular remodeling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Antiadrenergic therapy of chronic heart failure: surprises and new opportunities

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Cardiac excitation-contraction coupling

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Phospholamban: a promising therapeutic target in heart failure?

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Rescue of cardiomyocyte dysfunction by phospholamban ablation does not prevent ventricular failure in genetic hypertrophy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Dilated cardiomyopathy and heart failure caused by a mutation in phospholamban

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

The MLP family of cytoskeletal Z disc proteins and dilated cardiomyopathy: a stress pathway model for heart failure progression

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

The Genetic Basis for Cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

From sarcomeric mutations to heart disease: understanding familial hypertrophic cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Manipulating the contractile apparatus: genetically defined animal models of cardiovascular disease

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Actin mutations in dilated cardiomyopathy, a heritable form of heart failure

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Desmin mutation responsible for idiopathic dilated cardiomyopathy

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

An abnormal Ca(2+) response in mutant sarcomere protein-mediated familial hypertrophic cardiomyopathy

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Sex is a potent modifier of the cardiovascular system

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Molecular and cellular mechanisms of cardiac arrhythmias

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

21 January 2018

Cardiac channelopathies

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Mutations in the hminK gene cause long QT syndrome and suppress IKs function

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Abnormal cardiac conduction and morphogenesis in connexin40 and connexin43 double-deficient mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Progressive atrioventricular conduction defects and heart failure in mice expressing a mutant Csx/Nkx2.5 homeoprotein

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

A novel genetic pathway for sudden cardiac death via defects in the transition between ventricular and conduction system cell lineages

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Mobilized bone marrow cells repair the infarcted heart, improving function and survival

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Regeneration of the infarcted heart with stem cells derived by nuclear transplantation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Cellular therapies for myocardial infarct repair

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Cardiomyocyte cell cycle regulation

21 January 2018

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https://api.crossref.org/works/10.1038%2FNM0504-467

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Transplantation of Progenitor Cells and Regeneration Enhancement in Acute Myocardial Infarction (TOPCARE-AMI)

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Skeletal muscle stem cells do not transdifferentiate into cardiomyocytes after cardiac grafting

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Adult cardiac stem cells are multipotent and support myocardial regeneration

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Small molecules that induce cardiomyogenesis in embryonic stem cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Heart regeneration in zebrafish

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Heart regeneration in adult MRL mice

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

A role for bone morphogenetic proteins in the induction of cardiac myogenesis

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

7 January 2021

Molecular and cellular mechanisms of myocardial stunning

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

7 January 2021

The genetic basis for cardiomyopathy: from mutation identification to mechanistic paradigms

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

7 January 2021

Hypertrophic cardiomyopathy

1 reference

https://api.crossref.org/works/10.1038%2FNM0504-467

7 January 2021

Identifiers

DOI

10.1038/NM0504-467

1 reference

10 August 2017

1 reference