Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation (Q35691559)

9 August 2017

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title

Regulation of the TGFbeta signalling pathway by ubiquitin-mediated degradation (English)

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9 August 2017

Luisa Izzi

1

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9 August 2017

Liliana Attisano

series ordinal

2

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9 August 2017

language of work or name

English

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publication date

1 March 2004

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9 August 2017

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9 August 2017

volume

23

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9 August 2017

issue

11

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9 August 2017

page(s)

2071-2078

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The screw gene encodes a ubiquitously expressed member of the TGF-beta family required for specification of dorsal cell fates in the Drosophila embryo

9 August 2017

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Distinct endocytic pathways regulate TGF-β receptor signalling and turnover

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Smurf1 interacts with transforming growth factor-beta type I receptor through Smad7 and induces receptor degradation

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MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma

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Control of Smad7 stability by competition between acetylation and ubiquitination

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Proteasomal degradation of Smad1 induced by bone morphogenetic proteins

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Regulation of transforming growth factor-beta signaling by protein inhibitor of activated STAT, PIASy through Smad3

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Transforming growth factor beta1 induces nuclear export of inhibitory Smad7

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Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF beta receptor for degradation

21 January 2018

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Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in transforming growth factor-beta signaling

21 January 2018

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A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1

21 January 2018

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Ubiquitin-dependent degradation of TGF-beta-activated smad2.

21 January 2018

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Repression of Smad transcriptional activity by PIASy, an inhibitor of activated STAT.

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Transforming growth factor beta activates Smad2 in the absence of receptor endocytosis

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Loss of Smad4 function in pancreatic tumors: C-terminal truncation leads to decreased stability

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SUMO--nonclassical ubiquitin

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Differential ubiquitination defines the functional status of the tumor suppressor Smad4.

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Role of Ras and Mapks in TGFbeta signaling

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SUMO, ubiquitin's mysterious cousin

21 January 2018

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Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads

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Internalization-dependent and -independent requirements for transforming growth factor beta receptor signaling via the Smad pathway

21 January 2018

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The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis.

21 January 2018

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Oncogenic ras represses transforming growth factor-beta /Smad signaling by degrading tumor suppressor Smad4.

21 January 2018

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A superfamily of protein tags: ubiquitin, SUMO and related modifiers

21 January 2018

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Mechanisms of TGF-beta signaling from cell membrane to the nucleus

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The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase

21 January 2018

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Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

21 January 2018

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Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

21 January 2018

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Signaling inputs converge on nuclear effectors in TGF-beta signaling

21 January 2018

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SARA, a FYVE domain protein that recruits Smad2 to the TGFbeta receptor

21 January 2018

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Jab1 antagonizes TGF-beta signaling by inducing Smad4 degradation

21 January 2018

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The anaphase-promoting complex mediates TGF-beta signaling by targeting SnoN for destruction

21 January 2018

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Regulation of cell polarity and protrusion formation by targeting RhoA for degradation

21 January 2018

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Smads and early developmental signaling by the TGFbeta superfamily

21 January 2018

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Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway

21 January 2018

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https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

Smurf1 facilitates myogenic differentiation and antagonizes the bone morphogenetic protein-2-induced osteoblast conversion by targeting Smad5 for degradation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

E3 Ubiquitin Ligase Smurf1 Mediates Core-binding Factor α1/Runx2 Degradation and Plays A Specific Role in Osteoblast Differentiation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

Evidence for a role of Smad3 and Smad2 in stabilization of the tumor-derived mutant Smad2.Q407R

21 January 2018

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

inferred from DOI database lookup

7 January 2021

based on heuristic

SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

inferred from DOI database lookup

7 January 2021

based on heuristic

Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4

1 reference

https://api.crossref.org/works/10.1038%2FSJ.ONC.1207412

inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1038/SJ.ONC.1207412

1 reference

Dimensions Publication ID

9 August 2017

1024114565

0 references

1 reference